Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules

Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter

(2012) A. Basseville et al.   CANCER RESEARCH

Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

(2012) Juan L. Mendoza et al.   CELL

Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function

(2012) Wael M. Rabeh et al.   CELL

ABCG2 null alleles define the Jr(a−) blood group phenotype

(2012) Teresa Zelinski et al.   NATURE GENETICS

Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior

(2012) Carole Saison et al.   NATURE GENETICS

Decreased extra-renal urate excretion is a common cause of hyperuricemia

(2012) Kimiyoshi Ichida et al.   Nature Communications

ABCG transporters and disease

(2011) Owen M. Woodward et al.   FEBS Journal

4-Phenylbutyrate Stimulates Hsp70 Expression through the Elp2 Component of Elongator and STAT-3 in Cystic Fibrosis Epithelial Cells

(2011) Laurence Suaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing Conformational Rescue Induced by a Chemical Corrector of F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutant

(2011) Wilson Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-Mediated Proteasomal Degradation of ABC Transporters: a New Aspect of Genetic Polymorphisms and Clinical Impacts

(2011) Hiroshi Nakagawa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization

(2010) Junichi Shigeta et al.   CANCER SCIENCE

Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

(2010) Zhanglin Ni et al.   CURRENT DRUG METABOLISM

The Cystic Fibrosis-causing Mutation ΔF508 Affects Multiple Steps in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis

(2010) Patrick H. Thibodeau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A ‘complexity’ of urate transporters

(2010) Alan F. Wright et al.   KIDNEY INTERNATIONAL

The Primary Folding Defect and Rescue of ΔF508 CFTR Emerge during Translation of the Mutant Domain

(2010) Hanneke Hoelen et al.   PLoS One

Hyperuricemia and risk of stroke: A systematic review and meta-analysis

(2009) Seo Young Kim et al.   ARTHRITIS AND RHEUMATISM

Correctors Enhance Maturation of ΔF508 CFTR by Promoting Interactions between the Two Halves of the Molecule

(2009) Tip W. Loo et al.   BIOCHEMISTRY

The role of hyperuricemia and gout in kidney and cardiovascular disease

(2009) N. L. EDWARDS   CLEVELAND CLINIC JOURNAL OF MEDICINE

Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes?

(2009) Richard J. Johnson et al.   ENDOCRINE REVIEWS

Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure

(2009) Corinna Bergamini et al.   EUROPEAN JOURNAL OF HEART FAILURE

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

(2009) Darren M Hutt et al.   Nature Chemical Biology

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link?

(2009) Angelo L Gaffo et al.   ARTHRITIS RESEARCH & THERAPY

Quality control of human ABCG2 protein in the endoplasmic reticulum: Ubiquitination and proteasomal degradation

(2008) Kanako Wakabayashi-Nakao et al.   ADVANCED DRUG DELIVERY REVIEWS

Purification and structural analyses of ABCG2

(2008) Christopher A. McDevitt et al.   ADVANCED DRUG DELIVERY REVIEWS

Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships

(2008) Kristina V. Krasnov et al.   HUMAN MUTATION

Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society?

(2008) Richard J. Johnson et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations

(2008) Tomoka Furukawa et al.   PHARMACEUTICAL RESEARCH

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

(2008) A. W. R. Serohijos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE