Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

(2018) Steven Wink et al.   ARCHIVES OF TOXICOLOGY

Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat

(2018) Lu Chen et al.   FOOD AND CHEMICAL TOXICOLOGY

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

(2018) Sabine U Vorrink et al.   TOXICOLOGICAL SCIENCES

Characterization of hepatocyte-based in vitro systems for reliable toxicity testing

(2018) Mathieu Vinken et al.   ARCHIVES OF TOXICOLOGY

A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

(2018) Anna-Karin Sjögren et al.   ARCHIVES OF TOXICOLOGY

Bile micro-infarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood

(2018) Ahmed Ghallab et al.   HEPATOLOGY

In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism

(2018) Albert Braeuning et al.   ARCHIVES OF TOXICOLOGY

Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes

(2018) Laia Tolosa et al.   ARCHIVES OF TOXICOLOGY

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

(2018) Xiaolong Gu et al.   ARCHIVES OF TOXICOLOGY

Compound selection and annotation to validate the predictivity of in vitro toxicity assays for use in drug discovery, in response to Commentary by Dr. Zink (Zink, D. Arch Toxicol (2018))

(2018) Anna-Karin Sjögren et al.   ARCHIVES OF TOXICOLOGY

Detection of phenolic endocrine disrupting chemicals (EDCs) from maternal blood plasma and amniotic fluid in Indian population

(2017) Sudhanshu Shekhar et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

The ascending pathophysiology of cholestatic liver disease

(2017) Peter L.M. Jansen et al.   HEPATOLOGY

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

(2016) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice

(2016) Raymond Reif et al.   ARCHIVES OF TOXICOLOGY

Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict in Vivo Toxicity from in Vitro Data

(2016) Jochem Louisse et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cholestasis-induced adaptive remodeling of interlobular bile ducts

(2016) Nachiket Vartak et al.   HEPATOLOGY

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

(2016) Ahmed Ghallab et al.   JOURNAL OF HEPATOLOGY

Simultaneous determination of parabens, alkylphenols, phenylphenols, bisphenol A and triclosan in human urine, blood and breast milk by continuous solid-phase extraction and gas chromatography–mass spectrometry

(2016) Abdelmonaim Azzouz et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

(2015) HM Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells

(2015) Patricio Godoy et al.   JOURNAL OF HEPATOLOGY

A Systematic Evaluation of the Use of Physiologically Based Pharmacokinetic Modeling for Cross-Species Extrapolation

(2015) Christoph Thiel et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PharmGKB summary

(2015) Liudmila L. Mazaleuskaya et al.   Pharmacogenetics and Genomics

Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment

(2015) Miyoung Yoon et al.   TOXICOLOGY

Biokinetics in repeated-dosing in vitro drug toxicity studies

(2015) Nynke I. Kramer et al.   TOXICOLOGY IN VITRO

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis

(2014) Seddik Hammad et al.   ARCHIVES OF TOXICOLOGY

Toxicogenomics directory of chemically exposed human hepatocytes

(2014) Marianna Grinberg et al.   ARCHIVES OF TOXICOLOGY

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

(2014) Tanja Waldmann et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A decades-long investigation of acute metabolism-based hepatotoxicity by herbal constituents: a case study of pennyroyal oil

(2014) Perry Gordon et al.   DRUG METABOLISM REVIEWS

An Observational Study of Blood Concentrations and Kinetics of Methyl- and Propyl-Parabens in Neonates

(2014) H. Mulla et al.   PHARMACEUTICAL RESEARCH

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Phthalates and Parabens in Personal Care Products From China: Concentrations and Human Exposure

(2013) Ying Guo et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

(2013) Cliff Rowe et al.   HEPATOLOGY

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

(2012) Markus Schug et al.   ARCHIVES OF TOXICOLOGY

Characterization of Rat Liver Proteins Adducted by Reactive Metabolites of Menthofuran

(2012) S. Cyrus Khojasteh et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In Vitro - In Vivo Correlation of Gene Expression Alterations Induced by Liver Carcinogens

(2012) T. Heise et al.   CURRENT MEDICINAL CHEMISTRY

Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans

(2012) Salman R. Khetani et al.   TOXICOLOGICAL SCIENCES

Acute Alcohol-Induced Liver Injury

(2012) Veronica L. Massey et al.   Frontiers in Physiology

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Herbal bioactivation, molecular targets and the toxicity relevance

(2011) Xiao-Wu Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Plasma concentrations of parabens in postmenopausal women and self-reported use of personal care products: the NOWAC postgenome study

(2011) Torkjel M Sandanger et al.   Journal of Exposure Science and Environmental Epidemiology

A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing

(2010) Hans Mielke et al.   ARCHIVES OF TOXICOLOGY

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes

(2010) Sebastian Zellmer et al.   HEPATOLOGY

Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography–tandem mass spectrometry (LC–MS/MS)

(2010) Hanne Frederiksen et al.   Journal of Exposure Science and Environmental Epidemiology

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

(2010) S. Hoehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β-induced apoptosis

(2009) Patricio Godoy et al.   HEPATOLOGY

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES