标题
Beyond CAR T Cells: Other Cell-Based Immunotherapeutic Strategies Against Cancer
作者
关键词
-
出版物
Frontiers in Oncology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2019-04-10
DOI
10.3389/fonc.2019.00196
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- CRISPR/Cas9-mediated knockout of DGK improves anti-tumor activities of human T cells
- (2018) In-Young Jung et al. CANCER RESEARCH
- Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma
- (2018) Catherine M. Bollard et al. JOURNAL OF CLINICAL ONCOLOGY
- Gamma-delta (γδ) T cells: friend or foe in cancer development?
- (2018) Yijing Zhao et al. Journal of Translational Medicine
- Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation
- (2018) Anna Capsomidis et al. MOLECULAR THERAPY
- Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
- (2018) Christopher C. Kloss et al. MOLECULAR THERAPY
- CAR T cell immunotherapy for human cancer
- (2018) Carl H. June et al. SCIENCE
- Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo
- (2018) Sarwish Rafiq et al. NATURE BIOTECHNOLOGY
- Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting
- (2018) Antonia Rotolo et al. CANCER CELL
- CRISPR/Cas9-mediated PD-1 disruption enhances human mesothelin-targeted CAR T cell effector functions
- (2018) Wanghong Hu et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers
- (2018) Claudia Rossig et al. Frontiers in Oncology
- Identification of Novel Human NK Cell Progenitor Subsets
- (2017) Priyanka Sathe et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Clinical and immunological responses after CD30-specific chimeric antigen receptor–redirected lymphocytes
- (2017) Carlos A. Ramos et al. JOURNAL OF CLINICAL INVESTIGATION
- Ex Vivo-expanded Natural Killer Cells Derived From Long-term Cryopreserved Cord Blood are Cytotoxic Against Primary Breast Cancer Cells
- (2017) Tina Nham et al. JOURNAL OF IMMUNOTHERAPY
- Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity
- (2017) E Liu et al. LEUKEMIA
- Phase 1 Results of ZUMA-1: A Multicenter Study of KTE-C19 Anti-CD19 CAR T Cell Therapy in Refractory Aggressive Lymphoma
- (2017) Frederick L. Locke et al. MOLECULAR THERAPY
- Engineering Natural Killer Cells for Cancer Immunotherapy
- (2017) Katayoun Rezvani et al. MOLECULAR THERAPY
- Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer
- (2017) Somala Mohammed et al. MOLECULAR THERAPY
- The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments
- (2017) John P. Veluchamy et al. Frontiers in Immunology
- OP9 Feeder Cells Are Superior to M2-10B4 Cells for the Generation of Mature and Functional Natural Killer Cells from Umbilical Cord Hematopoietic Progenitors
- (2017) Lara Herrera et al. Frontiers in Immunology
- Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications
- (2017) Myriam Lawand et al. Frontiers in Immunology
- Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull mice
- (2017) Janneke S. Hoogstad-van Evert et al. OncoImmunology
- Adoptive Cell Transfer for Patients with Metastatic Melanoma: The Potential and Promise of Cancer Immunotherapy
- (2017) Giao Q. Phan et al. Cancer Control
- T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma
- (2016) S. A. Ali et al. BLOOD
- Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL2 Regimen
- (2016) R. Andersen et al. CLINICAL CANCER RESEARCH
- Improving efficacy of cancer immunotherapy by genetic modification of natural killer cells
- (2016) Rachel A. Burga et al. CYTOTHERAPY
- CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo
- (2016) Gengwen Tian et al. JOURNAL OF CLINICAL INVESTIGATION
- Tailored chemokine receptor modification improves homing of adoptive therapy T cells in a spontaneous tumor model
- (2016) Stefano Garetto et al. Oncotarget
- An NK cell line (haNK) expressing high levels of granzyme and engineered to express the high affinity CD16 allele
- (2016) Caroline Jochems et al. Oncotarget
- Toxicity and management in CAR T-cell therapy
- (2016) Challice L Bonifant et al. Molecular Therapy-Oncolytics
- Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient
- (2016) Imran Siddiqui et al. Journal for ImmunoTherapy of Cancer
- Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T
- (2015) Rachel A. Burga et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Challenges of cancer therapy with natural killer cells
- (2015) Hans Klingemann CYTOTHERAPY
- Adoptive T-cell therapy for cancer: The era of engineered T cells
- (2015) Chiara Bonini et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- CAR T-cell therapy: toxicity and the relevance of preclinical models
- (2015) Milena Kalaitsidou et al. Immunotherapy
- DAP12-Based Activating Chimeric Antigen Receptor for NK Cell Tumor Immunotherapy
- (2015) Katrin Töpfer et al. JOURNAL OF IMMUNOLOGY
- Chimeric Antigen Receptor– and TCR-Modified T Cells Enter Main Street and Wall Street
- (2015) David M. Barrett et al. JOURNAL OF IMMUNOLOGY
- Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer
- (2015) Naoyuki Sakamoto et al. Journal of Translational Medicine
- A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer
- (2015) Mythili Koneru et al. Journal of Translational Medicine
- Treatment of CD33-directed Chimeric Antigen Receptor-modified T Cells in One Patient With Relapsed and Refractory Acute Myeloid Leukemia
- (2015) Quan-shun Wang et al. MOLECULAR THERAPY
- The Role of Gamma Delta T Cells in Haematopoietic Stem Cell Transplantation
- (2015) L. Minculescu et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Present and Future of Allogeneic Natural Killer Cell Therapy
- (2015) Okjae Lim et al. Frontiers in Immunology
- Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress
- (2015) Meriem Hasmim et al. Frontiers in Immunology
- IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumorsin vivo
- (2015) Mythili Koneru et al. OncoImmunology
- Combined IL-15 and IL-12 drives the generation of CD34+-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer
- (2015) Jeannette Cany et al. OncoImmunology
- CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells against primary MDS and MDSC CD33+ targets
- (2014) M. K. Gleason et al. BLOOD
- Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy
- (2014) A. Heczey et al. BLOOD
- CD28z CARs and Armored CARs
- (2014) Hollie J. Pegram et al. CANCER JOURNAL
- Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies
- (2014) D. C. Deniger et al. CLINICAL CANCER RESEARCH
- Inhibition of Tumor-Derived Prostaglandin-E2 Blocks the Induction of Myeloid-Derived Suppressor Cells and Recovers Natural Killer Cell Activity
- (2014) Y. Mao et al. CLINICAL CANCER RESEARCH
- γδ T Cells and Their Potential for Immunotherapy
- (2014) Yan-Ling Wu et al. International Journal of Biological Sciences
- Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor
- (2014) Ann M Leen et al. MOLECULAR THERAPY
- Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
- (2014) M. L. Davila et al. Science Translational Medicine
- Natural killer cells in the treatment of high-risk acute leukaemia
- (2014) Franco Locatelli et al. SEMINARS IN IMMUNOLOGY
- Targeting CD20+ Aggressive B-cell Non-Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice
- (2014) Y. Chu et al. Cancer Immunology Research
- Heterodimeric Bispecific Single-Chain Variable-Fragment Antibodies Against EpCAM and CD16 Induce Effective Antibody-Dependent Cellular Cytotoxicity Against Human Carcinoma Cells
- (2013) Daniel A. Vallera et al. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
- A Chimeric Receptor with NKG2D Specificity Enhances Natural Killer Cell Activation and Killing of Tumor Cells
- (2013) Y.-H. Chang et al. CANCER RESEARCH
- Targeting Natural Killer Cells to Acute Myeloid Leukemia In Vitro with a CD16 x 33 Bispecific Killer Cell Engager and ADAM17 Inhibition
- (2013) A. Wiernik et al. CLINICAL CANCER RESEARCH
- Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells
- (2013) L. B. John et al. CLINICAL CANCER RESEARCH
- Toxicity management for patients receiving novel T-cell engaging therapies
- (2013) David M. Barrett et al. CURRENT OPINION IN PEDIATRICS
- Exploiting the curative potential of adoptive T-cell therapy for cancer
- (2013) Christian S. Hinrichs et al. IMMUNOLOGICAL REVIEWS
- The nanoparticulation by octaarginine-modified liposome improves α-galactosylceramide-mediated antitumor therapy via systemic administration
- (2013) Takashi Nakamura et al. JOURNAL OF CONTROLLED RELEASE
- IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
- (2013) Georg Gasteiger et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Blockade of TGF- Signaling Greatly Enhances the Efficacy of TCR Gene Therapy of Cancer
- (2013) G. M. Bendle et al. JOURNAL OF IMMUNOLOGY
- Modulation of natural killer cell effector functions through lenalidomide/dasatinib and their combined effects against multiple myeloma cells
- (2013) Isabel Jungkunz-Stier et al. LEUKEMIA & LYMPHOMA
- Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma
- (2013) Omid Hamid et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy
- (2013) J Shortt et al. ONCOGENE
- Co-Introduced Functional CCR2 Potentiates In Vivo Anti-Lung Cancer Functionality Mediated by T Cells Double Gene-Modified to Express WT1-Specific T-Cell Receptor
- (2013) Hiroaki Asai et al. PLoS One
- Combining a CD20 Chimeric Antigen Receptor and an Inducible Caspase 9 Suicide Switch to Improve the Efficacy and Safety of T Cell Adoptive Immunotherapy for Lymphoma
- (2013) Lihua E. Budde et al. PLoS One
- Lower Baseline Prostate-specific Antigen Is Associated With a Greater Overall Survival Benefit From Sipuleucel-T in the Immunotherapy for Prostate Adenocarcinoma Treatment (IMPACT) Trial
- (2013) Paul F. Schellhammer et al. UROLOGY
- Combination Immune Therapies to Enhance Anti-Tumor Responses by NK Cells
- (2013) Ashley Mentlik James et al. Frontiers in Immunology
- Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
- (2012) W. Haso et al. BLOOD
- Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma
- (2012) J. Richter et al. BLOOD
- CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
- (2012) B. G. Till et al. BLOOD
- Quality of life during dendritic cell vaccination against metastatic renal cell carcinoma
- (2012) Nicolai Leonhartsberger et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- CAR T cells transform to trucks: chimeric antigen receptor–redirected T cells engineered to deliver inducible IL-12 modulate the tumour stroma to combat cancer
- (2012) Markus Chmielewski et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Sipuleucel-T immune parameters correlate with survival: an analysis of the randomized phase 3 clinical trials in men with castration-resistant prostate cancer
- (2012) Nadeem A. Sheikh et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity
- (2012) G. Pietra et al. CANCER RESEARCH
- Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications
- (2012) Natalia Lapteva et al. CYTOTHERAPY
- A clinically adaptable method to enhance the cytotoxicity of natural killer cells against B-cell malignancies
- (2012) Noriko Shimasaki et al. CYTOTHERAPY
- Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy
- (2012) L Zhang et al. GENE THERAPY
- T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFβ) signaling mediate superior tumor regression in an animal model of adoptive cell therapy
- (2012) Jon G Quatromoni et al. Journal of Translational Medicine
- Bispecific and Trispecific Killer Cell Engagers Directly Activate Human NK Cells through CD16 Signaling and Induce Cytotoxicity and Cytokine Production
- (2012) M. K. Gleason et al. MOLECULAR CANCER THERAPEUTICS
- NK Cells: Key to Success of DC-Based Cancer Vaccines?
- (2012) E. Lion et al. ONCOLOGIST
- Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor
- (2011) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Effector T-Cell Infiltration Positively Impacts Survival of Glioblastoma Patients and Is Impaired by Tumor-Derived TGF-
- (2011) J. Lohr et al. CLINICAL CANCER RESEARCH
- Comparison of Clinical and Immunological Effects of Intravenous and Intradermal Administration of -GalactosylCeramide (KRN7000)-Pulsed Dendritic Cells
- (2011) A. J. Nicol et al. CLINICAL CANCER RESEARCH
- Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer
- (2011) Shinichiro Motohashi et al. CLINICAL IMMUNOLOGY
- Activation of invariant Natural Killer T lymphocytes in response to the α-galactosylceramide analogue KRN7000 encapsulated in PLGA-based nanoparticles and microparticles
- (2011) Elodie Macho Fernandez et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells
- (2011) Mercedes B. Fuertes et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Type I interferon is selectively required by dendritic cells for immune rejection of tumors
- (2011) Mark S. Diamond et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment
- (2011) Ling Zhang et al. MOLECULAR THERAPY
- Dendritic Cell Based Tumor Vaccination in Prostate and Renal Cell Cancer: A Systematic Review and Meta-Analysis
- (2011) Andreas Draube et al. PLoS One
- Tumor-Associated Macrophages Recruit CCR6+ Regulatory T Cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice
- (2011) Jinlin Liu et al. PLoS One
- Clinical-Grade Generation of Active NK Cells from Cord Blood Hematopoietic Progenitor Cells for Immunotherapy Using a Closed-System Culture Process
- (2011) Jan Spanholtz et al. PLoS One
- IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice
- (2010) J. C. Markley et al. BLOOD
- NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects
- (2010) J. A. Olson et al. BLOOD
- Allogeneic natural killer cells for refractory lymphoma
- (2010) Veronika Bachanova et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Clinical experience with α-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B/C infection
- (2010) Famke L. Schneiders et al. CLINICAL IMMUNOLOGY
- Clinical-grade, large-scale, feeder-free expansion of highly active human natural killer cells for adoptive immunotherapy using an automated bioreactor
- (2010) Tolga Sutlu et al. CYTOTHERAPY
- A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer
- (2010) Melissa A. Geller et al. CYTOTHERAPY
- Selective Expansion of Chimeric Antigen Receptor-targeted T-cells with Potent Effector Function using Interleukin-4
- (2010) Scott Wilkie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NKAML: A Pilot Study to Determine the Safety and Feasibility of Haploidentical Natural Killer Cell Transplantation in Childhood Acute Myeloid Leukemia
- (2010) Jeffrey E. Rubnitz et al. JOURNAL OF CLINICAL ONCOLOGY
- Enhanced Tumor Trafficking of GD2 Chimeric Antigen Receptor T Cells by Expression of the Chemokine Receptor CCR2b
- (2010) John A. Craddock et al. JOURNAL OF IMMUNOTHERAPY
- Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
- (2010) V Hoyos et al. LEUKEMIA
- CD169+ macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes
- (2010) Patricia Barral et al. NATURE IMMUNOLOGY
- Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer
- (2010) Philip W. Kantoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Defective NKT Cell Activation by CD1d+ TRAMP Prostate Tumor Cells Is Corrected by Interleukin-12 with alpha-Galactosylceramide
- (2010) Michael Nowak et al. PLoS One
- Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity
- (2009) S.-i. Fujii et al. BLOOD
- Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
- (2009) Celestia S. Higano et al. CANCER
- Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method
- (2009) L Li et al. CANCER GENE THERAPY
- Expansion of Highly Cytotoxic Human Natural Killer Cells for Cancer Cell Therapy
- (2009) H. Fujisaki et al. CANCER RESEARCH
- Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages
- (2009) Liping Song et al. JOURNAL OF CLINICAL INVESTIGATION
- A Phase I-II Study of -Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer
- (2009) S. Motohashi et al. JOURNAL OF IMMUNOLOGY
- Recombinant Vesicular Stomatitis Virus Transduction of Dendritic Cells Enhances Their Ability to Prime Innate and Adaptive Antitumor Immunity
- (2009) Jeanette E Boudreau et al. MOLECULAR THERAPY
- Genetic Manipulation of Tumor-specific Cytotoxic T Lymphocytes to Restore Responsiveness to IL-7
- (2009) Juan F Vera et al. MOLECULAR THERAPY
- Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components
- (2008) E. Alici et al. BLOOD
- Phase-I study of Innacell γδ™, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma
- (2008) Jaafar Bennouna et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Lenalidomide Enhances Natural Killer Cell and Monocyte-Mediated Antibody-Dependent Cellular Cytotoxicity of Rituximab-Treated CD20+ Tumor Cells
- (2008) L. Wu et al. CLINICAL CANCER RESEARCH
- Infusion of the allogeneic cell line NK-92 in patients with advanced renal cell cancer or melanoma: a phase I trial
- (2008) S. Arai et al. CYTOTHERAPY
- Antitumor Activity of EBV-specific T Lymphocytes Transduced With a Dominant Negative TGF-?? Receptor
- (2008) Aaron E. Foster et al. JOURNAL OF IMMUNOTHERAPY
- Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population
- (2008) J. M. Coquet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adoptive Transfer of Tumor-Reactive Transforming Growth Factor-β–Insensitive Cytolytic T Cells for Treatment of Established Mouse Renca Tumors
- (2008) Weijun Qin et al. UROLOGY
- Harnessing the tumour-derived cytokine, CSF-1, to co-stimulate T-cell growth and activation
- (2007) Agnes Shuk Yee Lo et al. MOLECULAR IMMUNOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started