Article
Oncology
Hans Raskov, Adile Orhan, Ali Salanti, Shruti Gaggar, Ismail Gogenur
Summary: NK cells play a crucial role in cancer treatment by recognizing and killing transformed cells, potentially improving treatment outcomes. Current research focuses on the development of immunotherapeutic approaches, including immune checkpoint inhibitors and adoptive cell transfer using T cells with chimeric antigen receptors to enhance immune function.
Review
Biochemistry & Molecular Biology
Tatiana Michel, Markus Ollert, Jacques Zimmer
Summary: Despite the challenges in cancer treatment, immunotherapy based on NK cells is considered to be one of the most promising options and has already shown success in clinical settings. This review highlights the different possibilities and mechanisms of NK cells in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jiacheng Bi, Chen Huang, Xiaomeng Jin, Chaoyue Zheng, Yingying Huang, Xiaohu Zheng, Zhigang Tian, Haoyu Sun
Summary: By analyzing single-cell transcriptomics and using gene reporter mice, this study found that TIPE2 expression correlated with NK cell exhaustion in the tumor microenvironment (TME) in both humans and mice. Deletion of TIPE2 improved the antitumor activity of adoptively transferred mouse NK cells and human NK cells, either derived from peripheral blood or induced pluripotent stem cells (iPSCs). Additionally, TIPE2 deletion synergized with CISH deletion to further enhance antitumor activity in vivo.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Nadine Landolina, Francesca Romana Mariotti, Tiziano Ingegnere, Claudia Alicata, Biancamaria Ricci, Andrea Pelosi, Irene Veneziani, Bruno Giuseppe Azzarone, Cecilia Garlanda, Alberto Mantovani, Lorenzo Moretta, Enrico Maggi
Summary: This study aimed to investigate the role of IL-1R8 in human NK cells and optimize its silencing conditions. The results showed that silencing IL-1R8 can enhance the activity and anti-tumor response of NK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Sainiteesh Maddineni, John L. Silberstein, John B. Sunwoo
Summary: This article reviews multiple approaches for allogeneic NK cell therapy and discusses the advantages and disadvantages of each method. In recent years, NK cells have become increasingly important players in the immune response against cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Seung Hee Choi, Hye Jin Kim, Joo Dong Park, Eun-Su Ko, Minwook Lee, Dae-Keum Lee, Jin-Ho Choi, Hye Jung Jang, Isaac Kim, Hae-Yun Jung, Keun-Hong Park, Kyung-Soon Park
Summary: The chemical priming of NK cells using 25KbPEI enhances their antitumor activity and migration ability, offering a simple and cost-effective method for producing therapeutic NK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Jiao Wang, Sandra Toregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia Atallah Lanman, Victor Bernal-Crespo, Matthew M. Behymer, Gregory T. Knipp, Yeonhee Yun, Michael C. Veronesi, Anthony L. Sinn, Karen E. Pollok, Randy R. Brutkiewicz, Kathryn S. Nevel, Sandro Matosevic
Summary: This study demonstrates a promising strategy utilizing genetically engineered human NK cells as a multifunctional immunotherapy to target multiple mechanisms of GBM progression simultaneously, including addressing antigen escape, immunometabolic reprogramming, and immune cell homing.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Genetics & Heredity
Meike Vogler, Senthan Shanmugalingam, Vinzenz Sarchen, Lisa Marie Reindl, Victoria Greze, Leon Buchinger, Michael Kuehn, Evelyn Ullrich
Summary: NK cells play a crucial role in cancer treatment, with their killing capacity determined by signals between NK cells and targeted tumor cells. Combining NK cell therapy with other agents can enhance therapeutic efficacy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Chemistry, Multidisciplinary
Min Li, Di Xie, Xinfeng Tang, Chen Yang, Yanqiong Shen, Han Zhou, Wuxian Deng, Jiwei Liu, Shanbao Cai, Li Bai, Yucai Wang
Summary: The study demonstrates that the use of photothermal therapy can enhance the antitumor ability of adoptively transferred NKT cells, leading to excellent growth inhibition of local tumors and efficient rejection of distant tumors. It also triggers long-term immunological memory to prevent tumor recurrence, showing promising potential for cancer immunotherapy.
Article
Biochemistry & Molecular Biology
Lucas Henrique Rodrigues da Silva, Luana Correia Croda Catharino, Viviane Jennifer da Silva, Gabriela Coeli Menezes Evangelista, Jose Alexandre Marzagao Barbuto
Summary: Natural killer (NK) cells are innate lymphocytes that play a vital role in immune surveillance against tumors. Various NK-based therapies, including transfer of expanded and activated cells, genetic engineering, cytokine therapy, and tumor-specific antibody-guided cells, are being used in cancer treatment. This article also discusses the potential approaches to control glioblastoma.
Article
Oncology
Xuan Guo, Tanel Mahlakoiv, Qian Ye, Srinivas Somanchi, Shuyang He, Hemlata Rana, Andrea DiFiglia, Joseph Gleason, William van der Touw, Robert Hariri, Xiaokui Zhang
Summary: The study successfully achieved 94% knockout efficiency of CBLB using CRISPR/Cas9 technology in placental CD34(+) cells, demonstrating the negative regulatory role of CBLB in PNK cell cytotoxicity against tumor cells. Ablation of CBLB did not impact PNK cell proliferation, differentiation, or phenotypical characteristics, but resulted in enhanced cytotoxicity against tumor cells. Furthermore, CBLB knockout PNK cells showed increased in vivo proliferation, maturation, and antitumor activity compared to unmodified PNK cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Oleksandr Kyrysyuk, Kai W. Wucherpfennig
Summary: T cells and NK cells have complementary roles in tumor immunity. Targeting immune evasion mechanisms and shared receptors between T cells and NK cells can enhance their immune response. Inhibitory and activating cytokines are also potential therapeutic strategies to impact lymphocyte function in tumors.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Oncology
Seong-Hoon Kim, Mi-Jin Kim, Mina Lim, Jihye Kim, Hyunmin Kim, Chang-Koo Yun, Yun-Joo Yoo, Youngjun Lee, Kyunghoon Min, Yong-Soo Choi
Summary: Conventional natural killer (NK)-based anticancer immunotherapy requires a 2-week culture period to enhance the activity and number of NK cells. By transferring allogeneic mitochondria into NK cells, we significantly enhanced their activity and cytotoxicity. This approach could offer a timely therapeutic strategy for cancer treatment without the need for time-consuming and costly in vitro culture.
Review
Cell Biology
Ali Bashiri Dezfouli, Mina Yazdi, Alan Graham Pockley, Mohammad Khosravi, Sebastian Kobold, Ernst Wagner, Gabriele Multhoff
Summary: In recent years, cell-based immunotherapies using Chimeric Antigen Receptors (CARs) have shown promise in cancer treatment, with CD19 CAR-engineered T cells being most commonly used for hematological malignancies. However, challenges in clinical applications include side effects like cytokine release syndrome, neurological symptoms, and off-target effects, necessitating the development of safer and more potent technologies. Natural Killer (NK) cells have emerged as a promising alternative, being capable of CAR engineering and exhibiting specialized lytic mechanisms against virally infected and cancer cells.
Article
Oncology
Chia-Ing Jan, Shi-Wei Huang, Peter Canoll, Jeffrey N. Bruce, Yu-Chuan Lin, Chih-Ming Pan, Hsin-Man Lu, Shao-Chih Chiu, Der-Yang Cho
Summary: The study introduces a novel CAR-NK strategy targeting HLA-G in solid tumors, which shows effective cytolytic action in vitro and in vivo. Combination therapy with low-dose chemotherapy enhances tumor ablation, suggesting a potential wide applicability in treating solid tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)