期刊
CLINICAL IMMUNOLOGY
卷 140, 期 2, 页码 130-141出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2010.11.010
关键词
iNKT cells; alpha-Galactosylceramide; KRN7000; Cancer; Chronic hepatitis B/C infection
类别
资金
- Netherlands Organization for Health Research and Development (ZonMw) [90700309]
- Dutch Cancer Society (KWF) [2010-4728]
For over a century, research has sought ways to boost the immune system in order to eradicate tumors and viruses that exist after escaping immunosurveillance. For the treatment of cancer and hepatitis immunotherapeutic strategies have overall had limited clinical success. An urgent need exists therefore to introduce more effective therapeutic approaches. Invariant (i)NKT cells constitute a conserved T lymphocyte lineage with dominant immunoregulatory, antitumor and antiviral effector cell properties. iNKT specifically recognize the glycolipid alpha-galactosylceramide in the context of CD1d resulting in their activation. Activated iNKT can promote the development of a long-lasting Th1 biased proinflammatory immune response as demonstrated in multiple tumor-metastasis and viral infection models. Here, we will provide a brief overview of the preclinical data of alpha-galactosylceramide that formed the basis for subsequent clinical trials in patients with advanced cancer and chronic hepatitis B/C, and elaborate on our own clinical experience with alpha-galactosylceramide in these patient groups. (C) 2010 Elsevier Inc. All rights reserved.
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