Phytochemicals Targeting VEGF and VEGF-Related Multifactors as Anticancer Therapy

Thymoquinone Effects on Cell Viability, Apoptosis and VEGF-A Gene Expression Level in AGS(CRL-1739) Cell Line

(2019) Mohsen Rashid et al.   Anti-Cancer Agents in Medicinal Chemistry

Anticancer Efficacy of the Combination of Berberine and PEGylated Liposomal Doxorubicin in Meth A Sarcoma-Bearing Mice

(2018) Jantana Yahuafai et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

3-O-Acetyloleanolic acid inhibits VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral cancer sentinel lymph node animal model

(2018) Jeon Hwang-Bo et al.   BMC CANCER

Anti-angiogenic activity and mechanism of a chemically sulfated natural glucan from Phellinus ribis

(2018) Yuhong Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis

(2018) Yuanqi Liu et al.   Journal of Natural Medicines

Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction

(2018) Lijun Jia et al.   LIFE SCIENCES

Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy

(2018) Amna Parveen et al.   MOLECULES

Expert consensus document: Advances in the diagnosis and classification of gastric and intestinal motility disorders

(2018) Jutta Keller et al.   Nature Reviews Gastroenterology & Hepatology

Emodin inhibits colon cancer cell invasion and migration by suppressing epithelialmesenchymal transition via the Wnt/β-catenin pathway

(2018) Juan Gu et al.   ONCOLOGY RESEARCH

Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway

(2018) Xuling Su et al.   Oxidative Medicine and Cellular Longevity

Evidence for the involvement of COX-2/VEGF and PTEN/Pl3K/AKT pathway the mechanism of oroxin B treated liver cancer

(2018) Xian-Sheng Meng et al.   Pharmacognosy Magazine

Bioactive phytochemicals that regulate the cellular processes involved in diabetic nephropathy

(2018) Amna Parveen et al.   PHYTOMEDICINE

Pharmacological and medical applications of Panax ginseng and ginsenosides: a review for use in cardiovascular diseases

(2018) Jong-Hoon Kim   Journal of Ginseng Research

Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis

(2018) Silas Pinto et al.   Redox Biology

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling

(2018) Tesfahun Dessale Admasu et al.   DEVELOPMENTAL CELL

Heterocyclic Compounds from the Mushroom Albatrellus confluens and Their Inhibitions against Lipopolysaccharides-Induced B Lymphocyte Cell Proliferation

(2018) Shuaibing Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

(2018) Franziska Pohl et al.   MOLECULES

Anticancer activity and phytochemical composition of wild Gundelia�tournefortii

(2018) Saleh Abu‑Lafi et al.   Oncology Letters

Effect of Kumatakenin Isolated From Cloves on the Apoptosis of Cancer Cells and the Alternative Activation of Tumor-Associated Macrophages

(2017) Jeong-Hwa Woo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neoalbaconol inhibits angiogenesis and tumor growth by suppressing EGFR-mediated VEGF production

(2017) Xinfang Yu et al.   MOLECULAR CARCINOGENESIS

Ginsenoside Rd regulates the Akt/mTOR/p70S6K signaling cascade and suppresses angiogenesis and breast tumor growth

(2017) Eryun Zhang et al.   ONCOLOGY REPORTS

Suppression of VEGF-induced angiogenesis and tumor growth by Eugenia jambolana, Musa paradisiaca, and Coccinia indica extracts

(2017) Harsha Raj M. et al.   PHARMACEUTICAL BIOLOGY

Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway

(2017) Yang Cao et al.   PLoS One

Celastrol, an active constituent of the TCM plant Tripterygium wilfordii Hook.f., inhibits prostate cancer bone metastasis

(2017) K Kuchta et al.   PROSTATE CANCER AND PROSTATIC DISEASES

From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

(2017) Thomas Efferth   SEMINARS IN CANCER BIOLOGY

Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth

(2017) Hao Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Artesunate inhibits proliferation and invasion of mouse hemangioendothelioma cells in?vitro and of tumor growth in?vivo

(2017) Ning Wang et al.   Oncology Letters

Anti-tumor bioactivities of curcumin on mice loaded with gastric carcinoma

(2017) Xiao-Ping Wang et al.   Food & Function

Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial

(2017) Hee Kim et al.   Nutrients

Tanshinone IIA inhibits angiogenesis in human endothelial progenitor cells in vitro and in vivo

(2017) Hsiang-Ping Lee et al.   Oncotarget

Plumbagin restrains hepatocellular carcinoma angiogenesis by suppressing the migration and invasion of tumor-derived vascular endothelial cells

(2017) YanFei Wei et al.   Oncotarget

Therapy Effects of Wogonin on Ovarian Cancer Cells

(2017) Jiang Ruibin et al.   Biomed Research International

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies

(2017) A.G.M. Mostofa et al.   Frontiers in Pharmacology

Lupeol and stigmasterol suppress tumor angiogenesis and inhibit cholangiocarcinoma growth in mice via downregulation of tumor necrosis factor-α

(2017) Thaned Kangsamaksin et al.   PLoS One

Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling

(2017) Peng Liu et al.   Scientific Reports

Esculetin Inhibits VEGF-Induced Angiogenesis Both In Vitro and In Vivo

(2016) Sung Lyea Park et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Anti-cancer effects of baicalein in non-small cell lung cancer in-vitro and in-vivo

(2016) Mary-Clare Cathcart et al.   BMC CANCER

Daphnetin inhibits TNF-α and VEGF-induced angiogenesis through inhibition of the IKKs/IκBα/NF-κB, Src/FAK/ERK1/2 and Akt signalling pathways

(2016) Abhishek Kumar et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Anticancer Activities of Medicinal Plants: Modulation of p53 Expression and Induction of Apoptosis

(2016) Amna Parveen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Recent Investigations for Discovery of Natural Antioxidants: A Comprehensive Review

(2016) Amna Parveen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Dual Role of p21 in the Progression of Cancer and Its Treatment

(2016) Amna Parveen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Quercetin inhibits angiogenesis by targeting calcineurin in the xenograft model of human breast cancer

(2016) Xin Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sinomenine prevents metastasis of human osteosarcoma cells via S phase arrest and suppression of tumor-related neovascularization and osteolysis through the CXCR4-STAT3 pathway

(2016) TAO XIE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Odisolane, a Novel Oxolane Derivative, and Antiangiogenic Constituents from the Fruits of Mulberry (Morus alba L.)

(2016) Seoung Rak Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pro-apoptotic and anti-angiogenic properties of the α /β-thujone fraction from Thuja occidentalis on glioblastoma cells

(2016) Angelo Torres et al.   JOURNAL OF NEURO-ONCOLOGY

Rosmarinic acid inhibits inflammation and angiogenesis of hepatocellular carcinoma by suppression of NF-κB signaling in H22 tumor-bearing mice

(2016) Wen Cao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Scopoletin, an active principle of tree tobacco (Nicotiana glauca) inhibits human tumor vascularization in xenograft models and modulates ERK1, VEGF-A, and FGF-2 in computer model

(2016) Yasser M. Tabana et al.   MICROVASCULAR RESEARCH

Arctigenin, a lignan from Arctium lappa L., inhibits metastasis of human breast cancer cells through the downregulation of MMP-2/−9 and heparanase in MDA-MB-231 cells

(2016) Chenghua Lou et al.   ONCOLOGY REPORTS

Delphinidin inhibits angiogenesis through the suppression of HIF-1α and VEGF expression in A549 lung cancer cells

(2016) Mun-Hyeon Kim et al.   ONCOLOGY REPORTS

Pomolic acid suppresses HIF1α/VEGF-mediated angiogenesis by targeting p38-MAPK and mTOR signaling cascades

(2016) Ji-Hyun Park et al.   PHYTOMEDICINE

The Development of an Angiogenic Protein “Signature” in Ovarian Cancer Ascites as a Tool for Biologic and Prognostic Profiling

(2016) Sofia-Paraskevi Trachana et al.   PLoS One

Role of NRP-1 in VEGF-VEGFR2-Independent Tumorigenesis

(2016) Chenxi Hu et al.   Targeted Oncology

Resveratrol and acetyl-resveratrol modulate activity of VEGF and IL-8 in ovarian cancer cell aggregates via attenuation of the NF-κB protein

(2016) Alexandria B. Tino et al.   Journal of Ovarian Research

Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy

(2016) Christopher C. Pan et al.   Oncotarget

Baicalein reduces angiogenesis in the inflammatory microenvironment via inhibiting the expression of AP-1

(2016) Yujie Huang et al.   Oncotarget

NRP2 transcriptionally regulates its downstream effector WDFY1

(2016) Samikshan Dutta et al.   Scientific Reports

Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?

(2016) Yu-Ling Li et al.   Cancer Biology & Medicine

New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment

(2016) Grace Gar-Lee Yue et al.   Scientific Reports

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

(2015) Stephanie M. Tortorella et al.   ANTIOXIDANTS & REDOX SIGNALING

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain

(2015) Deepitha Selvaraj et al.   CANCER CELL

Cdc42: Role in Cancer Management

(2015) Muhammad Imran Qadir et al.   Chemical Biology & Drug Design

Artesunate down-regulates immunosuppression from colorectal cancer Colon26 and RKO cells in vitro by decreasing transforming growth factor β1 and interleukin-10

(2015) Cheng Cui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sulforaphane inhibits hypoxia-induced HIF-1α and VEGF expression and migration of human colon cancer cells

(2015) DONG HWAN KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Neuropilin Functions as an Essential Cell Surface Receptor

(2015) Hou-Fu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

(2015) Matthew W. Parker et al.   STRUCTURE

Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer

(2015) Sadhna Aggarwal et al.   TUMOR BIOLOGY

Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo

(2015) Hironao Nakayama et al.   Scientific Reports

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Targeting RTK Signaling Pathways in Cancer

(2015) Tarik Regad   Cancers

The Role of Angiogenesis in Human Non-Hodgkin Lymphomas

(2015) Domenico Ribatti et al.   NEOPLASIA

Activation of the PI3K/Akt/mTOR/p70S6K Pathway is Involved in S100A4-induced Viability and Migration in Colorectal Cancer Cells

(2014) Haiyan Wang et al.   International Journal of Medical Sciences

Does the Immune System Naturally Protect Against Cancer?

(2014) Alexandre Corthay   Frontiers in Immunology

Inhibition of angiogenesis

(2013) Yuan Gu et al.   ANTI-CANCER DRUGS

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

(2013) Hira Lal Goel et al.   EMBO Molecular Medicine

How Vascular Endothelial Growth Factor-A (VEGF) Regulates Differentiation of Mesenchymal Stem Cells

(2013) Agnes D. Berendsen et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue

(2013) Robert Partyka et al.   MEDICAL SCIENCE MONITOR

Enhancing integrin function by VEGF/neuropilin signaling

(2013) Hira Lal Goel et al.   Cell Adhesion & Migration

Cardiac Toxicity of Anticancer Agents

(2013) Alessandro Colombo et al.   Current Cardiology Reports

Functional Role of Wogonin in Anti-Angiogenesis

(2012) Chiu-Mei Lin et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Vascular Endothelial Growth Factor Receptor 2 as a Marker for Malignant Vascular Tumors and Mesothelioma

(2012) Markku Miettinen et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Celastrol inhibits vasculogenesis by suppressing the VEGF-induced functional activity of bone marrow-derived endothelial progenitor cells

(2012) Shuai Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VEGF Inhibits Tumor Cell Invasion and Mesenchymal Transition through a MET/VEGFR2 Complex

(2012) Kan V. Lu et al.   CANCER CELL

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

VEGF Exerts an Angiogenesis-Independent Function in Cancer Cells to Promote Their Malignant Progression

(2012) Ying Cao et al.   CANCER RESEARCH

Targeting VEGF signalling via the neuropilin co-receptor

(2012) Snezana Djordjevic et al.   DRUG DISCOVERY TODAY

Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways

(2012) Poyil Pratheeshkumar et al.   PLoS One

Role of BMI1, a Stem Cell Factor, in Cancer Recurrence and Chemoresistance: Preclinical and Clinical Evidences

(2012) Hifzur Rahman Siddique et al.   STEM CELLS

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Inhibition of tumor specific angiogenesis by amentoflavone

(2011) C. Guruvayoorappan et al.   BIOCHEMISTRY-MOSCOW

The Immune Response to Tumors as a Tool toward Immunotherapy

(2011) F. Pandolfi et al.   Clinical & Developmental Immunology

Separation and Purification of Sulforaphane from Broccoli by Solid Phase Extraction

(2011) Dandan Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Biflavonoid Amentoflavone Inhibits Neovascularization Preventing the Activity of Proangiogenic Vascular Endothelial Growth Factors

(2011) Valeria Tarallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p16 Modulates VEGF Expression via Its Interaction With HIF-1α in Breast Cancer Cells

(2010) Jun Zhang et al.   CANCER INVESTIGATION

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia

(2010) Wei-Kang Wu et al.   IMMUNOBIOLOGY

Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development

(2010) Fu-Jung Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of vascular endothelial growth factor-induced angiogenesis by scopoletin through interrupting the autophosphorylation of VEGF receptor 2 and its downstream signaling pathways

(2010) Rong Pan et al.   VASCULAR PHARMACOLOGY

DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

(2009) I. Sorensen et al.   BLOOD

MMP-2 alters VEGF expression via αVβ3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells

(2009) Chandramu Chetty et al.   INTERNATIONAL JOURNAL OF CANCER

p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis

(2009) Eric Gee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

VEGF Stimulates the ERK 1/2 Signaling Pathway and Apoptosis in Cerebral Endothelial Cells After Ischemic Conditions

(2009) Purnima Narasimhan et al.   STROKE

TGFβ in Cancer

(2008) Joan Massagué   CELL

Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway

(2008) Paul Frankel et al.   EMBO REPORTS

Wogonin suppresses tumor growth in vivo and VEGF-induced angiogenesis through inhibiting tyrosine phosphorylation of VEGFR2

(2008) Na Lu et al.   LIFE SCIENCES