期刊
CHEMICAL BIOLOGY & DRUG DESIGN
卷 86, 期 4, 页码 432-439出版社
WILEY
DOI: 10.1111/cbdd.12556
关键词
Cdc42; cell division control protein; GTPase-activating proteins; guanine exchange factor
资金
- Chung-Ang University Seoul, South Korea
Contribution of Cdc42, a member of Rho family, has been characterized for the beginning of variety of cellular responses including cellular transformation, cell division, cell invasion, migration, invadopodia formation, enzyme activity, filopodia formation, and cell polarity in cells. Deregulation of Cdc42 can alter the normal functioning of the cells, responsible for the initiation of signaling pathways and is correlated with several pathogenic processes such as cancer. Therefore, maintaining the level of Cdc42 and its effectors in cells, tumor progression can be controlled. Therefore, it can be suggested that deeper understanding about the Cdc42 contribution in cancer cell progression at molecular level can approach to the development of Cdc42 inhibitors in cancer management.
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