Review
Cell Biology
Lara Rodriguez-Outeirino, Francisco Hernandez-Torres, F. Ramirez-de Acuna, Lidia Matias-Valiente, Cristina Sanchez-Fernandez, Diego Franco, Amelia Eva Aranega
Summary: Muscle regeneration is a crucial homeostatic process in adult skeletal muscle, sharing similarities with embryonic myogenesis. Satellite cells are the main muscle stem cells responsible for regeneration, displaying functional heterogeneity with undifferentiated subpopulations more prone to self-renewal and committed progenitor cells ready for myogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Amanda L. Johnson, Michael Kamal, Gianni Parise
Summary: Skeletal muscle has a remarkable ability to repair and remodel itself, which is mainly achieved through the action of satellite cells. Recent studies have shown the relationships between satellite cells and other cell types and structures in the muscle microenvironment. These findings highlight the essential role of crosstalk between inflammatory cells, fibrogenic cells, bone-marrow-derived cells, satellite cells, and the vasculature in muscle homeostasis restoration.
Review
Biochemistry & Molecular Biology
Francis X. Pizza, Kole H. Buckley
Summary: Injury to skeletal muscle initiates muscle regeneration, which involves the formation of regenerating myofibers with central myonuclei. However, little is known about the maturation process of regenerating myofibers into normal-sized myofibers with peripheral myonuclei. This review compares and contrasts myofiber maturation during muscle development and regeneration, aiming to identify unique cellular and molecular processes of myofiber maturation in muscle regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Tolulope Peter Saliu, Thanutchaporn Kumrungsee, Koji Mitsumoto, Siyi Chen, Noriyuki Yanaka
Summary: This study found that NAFLD significantly reduces the number of satellite cells in the skeletal muscle of mice, impairing muscle regeneration. Additionally, NAFLD also impairs the differentiation ability of satellite cells, possibly associated with inflammatory cytokines and oxidative stress.
Article
Biochemistry & Molecular Biology
Athanasios Moustogiannis, Anastassios Philippou, Orjona Taso, Evangelos Zevolis, Maria Pappa, Antonios Chatzigeorgiou, Michael Koutsilieris
Summary: This study investigated the impact of senescence/aging on skeletal myogenesis through in vitro experiments. Aged myoblasts showed cell cycle arrest, DNA damage, increased SA-beta-gal activity, and altered expression of various factors compared to control cells during differentiation. The findings suggest that aging disrupts myogenic lineage and leads to a reduction in differentiation capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Kasun Kodippili, Michael A. Rudnicki
Summary: Progressive muscle weakness and degeneration are characteristic of Duchenne muscular dystrophy (DMD), a fatal, x-linked neuromuscular disorder affecting 1 in 5,000 boys. Loss of dystrophin protein results in recurrent muscle degeneration, progressive fibrosis, chronic inflammation, and dysfunction of satellite cells, which are skeletal muscle resident stem cells. Currently, there is no cure for DMD. This mini review discusses the impaired functionality of satellite cells in dystrophic muscle, its contribution to DMD pathology, and the potential of restoring endogenous satellite cell function as a viable treatment strategy.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rachel J. Waldemer-Streyer, Dongwook Kim, Jie Chen
Summary: Regeneration of adult skeletal muscle in mammals is a complex process regulated by multiple proteins and signaling pathways. Cytokines play a crucial role in skeletal myogenesis, with both infiltrating immune cells and the muscle itself secreting these signaling molecules. This review focuses on muscle-secreted cytokines that have been shown to be involved in myogenic differentiation and muscle regeneration.
Review
Cell Biology
So-ichiro Fukada, Tatsuyoshi Higashimoto, Akihiro Kaneshige
Summary: Skeletal muscle homeostasis and function are maintained by cellular interactions. The behavior of muscle satellite cells differs in the processes of regeneration and muscle hypertrophy.
Article
Cell & Tissue Engineering
Morgan D. Zumbaugh, Ashley E. Geiger, Jing Luo, Zhengxing Shen, Hao Shi, David E. Gerrard
Summary: The study revealed that O-GlcNAcylation plays a critical role in the maintenance of muscle satellite cell health and function. Deficiency of OGT affects the proliferation, self-renewal, and repair capacity of SCs in injured muscle.
Article
Rehabilitation
Mario Parstorfer, Francesca Profit, Nadine Weiberg, Michaela Wehrstein, Alexander Barie, Birgit Friedmann-Bette
Summary: This study investigated satellite cell content and function of the vastus lateralis muscle after anterior ligament reconstruction. The findings showed that satellite cell apoptosis increased while the total satellite cell number decreased post-reconstruction, suggesting a potential explanation for prolonged quadriceps muscle atrophy.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Eun Ju Lee, Sibhghatulla Shaikh, Mohammad Hassan Baig, So-Young Park, Jeong Ho Lim, Syed Sayeed Ahmad, Shahid Ali, Khurshid Ahmad, Inho Choi
Summary: This study reports the potential of novel peptides MIF1 and MIF2 derived from MSTN in enhancing myogenesis and reducing adipogenesis. Modified MIF1 and MIF2 showed better cell proliferation and differentiation compared to non-modified peptides. Pretreatment of mice with (Ac)-MIF1 or (Ac)-MIF2-(NH2) promoted muscle regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Na Liang, Jia He, Jiaqi Yan, Xueying Han, Xiaoqian Zhang, Yamei Niu, Wuga Sha, Jun Li
Summary: DBC1 knockdown in skeletal muscle leads to muscle atrophy and impairs muscle regeneration through the regulation of FOXO3. This research highlights the importance of DBC1 for healthy skeletal muscle function and its connection to muscular atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Jianjun Jin, Mengmeng Du, Jian Wang, Yubo Guo, Jiali Zhang, Hao Zuo, Yunqing Hou, Shanshan Wang, Wei Lv, Wei Bai, Jin Wang, Xizhen Zhan, Yaxin Peng, Qian Tong, Jin Chai, Zaiyan Xu, Bo Zuo
Summary: The study identified SYISL as a conserved lncRNA that modulates myogenesis in mice, pigs, and humans, and also demonstrated its previously unknown ability to promote muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Yi-Ju Chen, Rathinasamy Baskaran, Ching Fang Chang, Zuhair M. Mohammedsaleh, Wan-Teng Lin
Summary: Sarcopenia, age-related muscle loss, has negative health consequences such as decreased strength and insulin resistance. The bioactive peptide DI-10 promotes myoblast differentiation and upregulates mitochondrial-related transcription factors under hyperglycemic conditions. This suggests DI-10's potential as a therapeutic candidate for preventing muscle degeneration in sarcopenia.
Article
Biochemistry & Molecular Biology
Oscar Horwath, Fabian Nordstrom, Ferdinand von Walden, William Apro, Marcus Moberg
Summary: Cumulative evidence supports the hypothesis that hypoxia acts as a regulator of muscle mass. This study examined the effect of hypoxia on signaling pathways and gene expression in human skeletal muscle after resistance exercise. The results showed that hypoxia attenuated ribosome signaling but did not affect satellite cell pool expansion and myogenic gene expression.
Review
Oncology
Renata de Castro Goncalves, Paula Paccielli Freire, Dario Coletti, Marilia Seelaender
Summary: Cachexia is a syndrome affecting the entire organism, especially prevalent in cancer patients, involving systemic inflammation and immunosuppression. The imbalance of autophagy within the tumor microenvironment can lead to chronic inflammation and immune dysfunction, impacting both tumor progression and cachexia development. Understanding this complex relationship may improve cancer treatment outcomes and prevent/mitigate cancer cachexia.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Gabriela S. de Castro, Joanna Correia-Lima, Estefania Simoes, Camila E. Orsso, Jingjie Xiao, Leonardo R. Gama, Silvio P. Gomes, Daniela Caetano Goncalves, Raquel G. F. Costa, Katrin Radloff, Ulrike Lenz, Anna E. Taranko, Fang Chia Bin, Fernanda B. Formiga, Louisie G. L. de Godoy, Rafael P. de Souza, Luis H. A. Nucci, Mario Feitoza, Claudio C. de Castro, Flavio Tokeshi, Paulo S. M. Alcantara, Jose P. Otoch, Alexandre F. Ramos, Alessandro Laviano, Dario Coletti, Vera C. Mazurak, Carla M. Prado, Marilia Seelaender
Summary: This study found that the content of myokines in skeletal muscle, plasma, and tumors is impacted by cachexia, with decreased FSTL-1 expression in skeletal muscle and increased levels of FABP3, IL-15, and irisin found in cachectic patients. Additionally, indices of lumbar adipose tissue and muscularity were lower in cachexia patients.
CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Raphaelle Grifone, Audrey Saquet, Manon Desgres, Claudia Sangiorgi, Caterina Gargano, Zhenlin Li, Dario Coletti, De-Li Shi
Summary: Rbm24 plays multiple roles in muscle regeneration by regulating myogenic differentiation and muscle-specific pre-mRNA alternative splicing. It is rapidly upregulated in regenerating myofibers post-injury and shows nuclear localization in nascent myofibers.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Keller, Elisa Manzocchi, Deborah Rentsch, Rosamaria Lugara, Katrin Giller
Summary: Replacing soybean meal with spirulina in the diets of dairy cows and fattening bulls did not show significant antioxidant and anti-inflammatory effects in ruminants. Future studies should focus on evaluating the microbial degradation of spirulina and its bioactive compounds in the rumen to provide more data on potential beneficial health effects in ruminants.
Review
Biochemistry & Molecular Biology
Alessandra Renzini, Carles Sanchez Riera, Isidora Minic, Chiara D'Ercole, Biliana Lozanoska-Ochser, Alessia Cedola, Giuseppe Gigli, Viviana Moresi, Luca Madaro
Summary: The skeletal muscle, as a highly responsive tissue, undergoes metabolic changes in response to external demand. Various atrophic conditions, such as aging, ALS, and cancer-induced cachexia, lead to muscle wasting through different molecular signaling pathways. Nutritional interventions and physical exercise have been shown to be effective tools for counteracting muscle wasting in atrophic conditions.
Article
Geriatrics & Gerontology
Alessandra Renzini, Nicoletta Marroncelli, Giorgia Cavioli, Silvia Di Francescantonio, Laura Forcina, Alessandro Lambridis, Eros Di Giorgio, Sergio Valente, Antonello Mai, Claudio Brancolini, Claudia Giampietri, Alessandra Magenta, Francesca De Santa, Sergio Adamo, Dario Coletti, Viviana Moresi
Summary: The study reveals the crucial role of HDAC4 in mediating muscle repair response, suggesting potential therapeutic approaches for muscular dystrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Biochemistry & Molecular Biology
Silvia Consalvi, Luca Tucciarone, Elisa Macri, Marco De Bardi, Mario Picozza, Illari Salvatori, Alessandra Renzini, Sergio Valente, Antonello Mai, Viviana Moresi, Pier Lorenzo Puri
Summary: Late-stage mdx FAPs exhibit abnormal HDAC activity and genome-wide alterations of histone acetylation that cannot be fully reversed by HDACi. HDACi show general resistance in inducing H3K9/14 hyperacetylation in late-stage mdx FAPs, but is effective in reducing promoter acetylation and blunting SASP gene activation.
Article
Food Science & Technology
R. Lugara, L. Realini, M. Kreuzer, K. Giller
Summary: This study found a sex-specific programming effect on offspring growth in response to maternal spirulina intake, but high energy intake had no effect. Spirulina intake did not affect meat quality, but it may improve the ratio of polyunsaturated fatty acids/saturated fatty acids in offspring meat.
Article
Agriculture, Dairy & Animal Science
Rosamaria Lugara, Lukasz Grzeskowiak, Juergen Zentek, Susanne Meese, Michael Kreuzer, Katrin Giller
Summary: High-energy or high-fat diets do not directly affect the reproductive and lactational traits in sows, but may potentially impact offspring growth and health through modifying the colostrum fatty acid profile. The microalga spirulina does not directly affect the reproduction and lactation traits in sows, but may potentially influence the proportion of males and females in offspring.
Article
Nutrition & Dietetics
Rosamaria Lugara, Simone Renner, Eckhard Wolf, Annette Liesegang, Rupert Bruckmaier, Katrin Giller
Summary: Excessive intake of fats and sugars in the Western diet is a major cause of obesity. This study investigated the effects of Western diet and spirulina supplementation on gestating and lactating domestic pigs as a model for metabolic disturbances. The results suggest that domestic pigs have limited suitability as a model for Western diet-induced metabolic impairments, but low-dose spirulina supplementation can partially attenuate the negative effects.
Article
Multidisciplinary Sciences
Marc Beltra, Fabrizio Pin, Domiziana Costamagna, Robin Duelen, Alessandra Renzini, Riccardo Ballaro, Lorena Garcia-Castillo, Ambra Iannuzzi, Viviana Moresi, Dario Coletti, Maurilio Sampaolesi, Fabio Penna, Paola Costelli
Summary: This study reveals that overexpression of PGC-1 alpha in myofibers alters the proportion of MuSCs and ISCs, leading to enhanced fusion of myogenic progenitors with recipient myofibers and reduced adipogenesis in skeletal muscle.
Review
Biochemistry & Molecular Biology
Viviana Moresi, Alessandra Renzini, Giorgia Cavioli, Marilia Seelaender, Dario Coletti, Giuseppe Gigli, Alessia Cedola
Summary: Neurogenic muscle atrophy is a condition associated with diseases and aging, leading to reduced interaction between motoneurons and skeletal fibers. Current therapeutic approaches provide no concrete resolution. Nutritional support could play a relevant part in mitigating neurogenic muscle atrophy.
Review
Biochemistry & Molecular Biology
Martina Sandona, Giorgia Cavioli, Alessandra Renzini, Alessia Cedola, Giuseppe Gigli, Dario Coletti, Timothy A. McKinsey, Viviana Moresi, Valentina Saccone
Summary: Histone deacetylases (HDACs) regulate the deacetylation of proteins, affecting cellular processes. Abnormal HDAC expression or activity is associated with various pathologies, making them potential therapeutic targets. For example, HDAC inhibitors have shown positive effects in preclinical and clinical studies for Duchenne Muscular Dystrophy (DMD). Understanding the cellular functions of HDACs in dystrophic muscles provides new insights for the development of effective therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Chiara Della Peruta, Biliana Lozanoska-Ochser, Alessandra Renzini, Viviana Moresi, Carles Sanchez Riera, Marina Bouche, Dario Coletti
Summary: Thanks to precision medicine, personalized treatments based on sex have emerged in recent years. Male and female skeletal muscles have significant differences, which impacts diagnosis and therapy. Men have more muscle and exhibit different inflammation responses, leading to different treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
