Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs

From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and Beyond

(2018) Flavia Michelini et al.   CHEMICAL REVIEWS

Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications

(2018) Ruth Chia et al.   LANCET NEUROLOGY

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

(2018) Wei-Ting Lu et al.   Nature Communications

Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage

(2017) Kaspar Burger et al.   JOURNAL OF CELL BIOLOGY

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

(2017) Flavia Michelini et al.   NATURE CELL BIOLOGY

The control of DNA repair by the cell cycle

(2017) Nicole Hustedt et al.   NATURE CELL BIOLOGY

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks

(2017) Fabio Iannelli et al.   Nature Communications

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

(2017) Francesca Rossiello et al.   Nature Communications

DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors

(2016) Sofia Francia et al.   JOURNAL OF CELL SCIENCE

Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants

(2016) Yiping Qi et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A unifying mechanism in neurodegeneration

(2016) Christopher A. Ross et al.   NATURE

TDP-43/FUS in motor neuron disease: Complexity and challenges

(2016) Erika N. Guerrero et al.   PROGRESS IN NEUROBIOLOGY

TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments

(2016) Mohamed Fareh et al.   Nature Communications

WRN regulates pathway choice between classical and alternative non-homologous end joining

(2016) Raghavendra A. Shamanna et al.   Nature Communications

Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum

(2016) Vijay Swahari et al.   Cell Reports

53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks

(2016) Josée Guirouilh-Barbat et al.   PLoS Genetics

CRISPR-Cas9D10A nickase-based genotypic and phenotypic screening to enhance genome editing

(2016) Ting-Wei Will Chiang et al.   Scientific Reports

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

(2015) A. Emde et al.   EMBO JOURNAL

Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males

(2015) A. J. Modzelewski et al.   JOURNAL OF CELL SCIENCE

Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis

(2015) Ross C. Wilson et al.   MOLECULAR CELL

Swiss army knives: non-canonical functions of nuclear Drosha and Dicer

(2015) Kaspar Burger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination

(2014) Min Gao et al.   CELL RESEARCH

Nuclear position dictates DNA repair pathway choice

(2014) Charlène Lemaître et al.   GENES & DEVELOPMENT

CtIP-mediated resection is essential for viability and can operate independently of BRCA1

(2014) Federica Polato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin

(2014) Andreas Kakarougkas et al.   MOLECULAR CELL

DNA Damage and Its Links to Neurodegeneration

(2014) Ram Madabhushi et al.   NEURON

CHK2 kinase in the DNA damage response and beyond

(2014) L. Zannini et al.   Journal of Molecular Cell Biology

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

(2014) Simran Khurana et al.   Cell Reports

RNAi Factors Are Present and Active in Human Cell Nuclei

(2014) Keith T. Gagnon et al.   Cell Reports

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

(2014) Mireille Bétermier et al.   PLoS Genetics

OpenComet: An automated tool for comet assay image analysis

(2014) Benjamin M. Gyori et al.   Redox Biology

Enoxacin inhibits growth of prostate cancer cells and effectively restores microRNA processing

(2013) Elsa J. Sousa et al.   Epigenetics

A two-step mechanism for TRF2-mediated chromosome-end protection

(2013) Keiji Okamoto et al.   NATURE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

(2013) Ho Young Lee et al.   NUCLEIC ACIDS RESEARCH

A direct role for small non-coding RNAs in DNA damage response

(2013) Fabrizio d’Adda di Fagagna   TRENDS IN CELL BIOLOGY

53BP1: pro choice in DNA repair

(2013) Michal Zimmermann et al.   TRENDS IN CELL BIOLOGY

A Role for Small RNAs in DNA Double-Strand Break Repair

(2012) Wei Wei et al.   CELL

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing

(2011) S. Melo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Over-expression of miR-100 is responsible for the low-expression of ATM in the human glioma cell line: M059J

(2010) Wooi Loon Ng et al.   DNA REPAIR

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM

(2010) Y Wang et al.   ONCOGENE

ATM is down-regulated by N-Myc-regulated microRNA-421

(2010) H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

A small molecule enhances RNA interference and promotes microRNA processing

(2008) Ge Shan et al.   NATURE BIOTECHNOLOGY