Swiss army knives: non-canonical functions of nuclear Drosha and Dicer

A Variety of Dicer Substrates in Human and C. elegans

(2014) Agnieszka Rybak-Wolf et al.   CELL

Argonaute-Bound Small RNAs from Promoter-Proximal RNA Polymerase II

(2014) Jesse R. Zamudio et al.   CELL

piRNAs: from biogenesis to function

(2014) E.-M. Weick et al.   DEVELOPMENT

Functional Diversification of Dicer-like Proteins and Small RNAs Required for Genome Sculpting

(2014) Pamela Y. Sandoval et al.   DEVELOPMENTAL CELL

Determinants of Heterochromatic siRNA Biogenesis and Function

(2014) Ruby Yu et al.   MOLECULAR CELL

R-loops induce repressive chromatin marks over mammalian gene terminators

(2014) Konstantina Skourti-Stathaki et al.   NATURE

Small RNAs break out: the molecular cell biology of mobile small RNAs

(2014) Peter Sarkies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape

(2014) Germano Cecere et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA

(2014) Eleanor White et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA-directed DNA methylation requires stepwise binding of silencing factors to long non-coding RNA

(2014) Gudrun Böhmdorfer et al.   PLANT JOURNAL

Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis

(2014) A. Luhur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosha as an interferon-independent antiviral factor

(2014) J. S. Shapiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi Factors Are Present and Active in Human Cell Nuclei

(2014) Keith T. Gagnon et al.   Cell Reports

Drosha Promotes Splicing of a Pre-microRNA-like Alternative Exon

(2014) Mallory A. Havens et al.   PLoS Genetics

RNase III: Genetics and Function; Structure and Mechanism

(2013) Donald L. Court et al.   Annual Review of Genetics

A Retrotransposon-Driven Dicer Isoform Directs Endogenous Small Interfering RNA Production in Mouse Oocytes

(2013) Matyas Flemr et al.   CELL

Endogenous Nuclear RNAi Mediates Behavioral Adaptation to Odor

(2013) Bi-Tzen Juang et al.   CELL

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

(2013) Vincent C. Auyeung et al.   CELL

A novel mechanism underlies caspase-dependent conversion of the dicer ribonuclease into a deoxyribonuclease during apoptosis

(2013) Xiao Ge et al.   CELL RESEARCH

The mitochondrial genome encodes abundant small noncoding RNAs

(2013) Seungil Ro et al.   CELL RESEARCH

A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism

(2013) D. B. Marina et al.   GENES & DEVELOPMENT

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

(2013) P. A. Ginno et al.   GENOME RESEARCH

Cyclin-dependent Kinase 9 Links RNA Polymerase II Transcription to Processing of Ribosomal RNA

(2013) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone 3 S10 Phosphorylation: “Caught in the R Loop!”

(2013) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Alternative Splicing Regulates Biogenesis of miRNAs Located across Exon-Intron Junctions

(2013) Ze’ev Melamed et al.   MOLECULAR CELL

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

(2013) Stephane E. Castel et al.   NATURE REVIEWS GENETICS

Argonaute proteins: functional insights and emerging roles

(2013) Gunter Meister   NATURE REVIEWS GENETICS

Charity begins at home: non-coding RNA functions in DNA repair

(2013) Dipanjan Chowdhury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Noncoding RNAs prevent spreading of a repressive histone mark

(2013) Claudia Keller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Microprocessor controls the activity of mammalian retrotransposons

(2013) Sara R Heras et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

(2013) Ho Young Lee et al.   NUCLEIC ACIDS RESEARCH

RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators

(2013) A. D. Redfern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways

(2013) Arne Weiberg et al.   SCIENCE

Drosha Regulates Gene Expression Independently of RNA Cleavage Function

(2013) Natalia Gromak et al.   Cell Reports

A Truncated Form of Dicer Tilts the Balance of RNA Interference Pathways

(2013) Ahilya N. Sawh et al.   Cell Reports

Transcription Termination and Chimeric RNA Formation Controlled by Arabidopsis thaliana FPA

(2013) Céline Duc et al.   PLoS Genetics

Convergent Transcription Induces Dynamic DNA Methylation at disiRNA Loci

(2013) Yunkun Dang et al.   PLoS Genetics

RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells

(2013) Constance Ciaudo et al.   PLoS Genetics

Microprocessor, Setx, Xrn2, and Rrp6 Co-operate to Induce Premature Termination of Transcription by RNAPII

(2012) Alexandre Wagschal et al.   CELL

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88

(2012) Valeria Tarallo et al.   CELL

Dicer Partner Proteins Tune the Length of Mature miRNAs in Flies and Mammals

(2012) Ryuya Fukunaga et al.   CELL

A Role for Small RNAs in DNA Double-Strand Break Repair

(2012) Wei Wei et al.   CELL

RNAi keeps Atf1-bound stress response genes in check at nuclear pores

(2012) K. J. Woolcock et al.   GENES & DEVELOPMENT

Cytoplasmic Assembly and Selective Nuclear Import of Arabidopsis ARGONAUTE4/siRNA Complexes

(2012) Ruiqiang Ye et al.   MOLECULAR CELL

Conservation between the RNA Polymerase I, II, and III Transcription Initiation Machineries

(2012) Alessandro Vannini et al.   MOLECULAR CELL

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

The microcosmos of cancer

(2012) Amaia Lujambio et al.   NATURE

Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint

(2012) Sam Guoping Gu et al.   NATURE GENETICS

Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs

(2012) Philip Knuckles et al.   NATURE NEUROSCIENCE

DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

(2012) Sara Macias et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DICER- and AGO3-dependent generation of retinoic acid–induced DR2 Alu RNAs regulates human stem cell proliferation

(2012) QiDong Hu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A small RNA response at DNA ends in Drosophila

(2012) Katharina M. Michalik et al.   NUCLEIC ACIDS RESEARCH

Evidence for a cytoplasmic microprocessor of pri-miRNAs

(2012) J. S. Shapiro et al.   RNA

Cotranscriptional Role for Arabidopsis DICER-LIKE 4 in Transcription Termination

(2012) F. Liu et al.   SCIENCE

MicroRNAs in neuronal function and dysfunction

(2012) Heh-In Im et al.   TRENDS IN NEUROSCIENCES

The Essential Function of B. subtilis RNase III Is to Silence Foreign Toxin Genes

(2012) Sylvain Durand et al.   PLoS Genetics

Global Regulatory Functions of the Staphylococcus aureus Endoribonuclease III in Gene Expression

(2012) Efthimia Lioliou et al.   PLoS Genetics

An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer

(2011) Pierre Barraud et al.   EMBO JOURNAL

Ending the message: poly(A) signals then and now

(2011) N. J. Proudfoot   GENES & DEVELOPMENT

Mechanisms and Consequences of Alternative Polyadenylation

(2011) Dafne Campigli Di Giammartino et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

(2011) Hiroki Kaneko et al.   NATURE

RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II

(2011) Mikel Zaratiegui et al.   NATURE

Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila

(2011) Filippo M. Cernilogar et al.   NATURE

Unravelling the means to an end: RNA polymerase II transcription termination

(2011) Jason N. Kuehner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PIWI-interacting small RNAs: the vanguard of genome defence

(2011) Mikiko C. Siomi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Depletion of key protein components of the RISC pathway impairs pre-ribosomal RNA processing

(2011) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

Upregulation of Cyclin B1 by miRNA and its implications in cancer

(2011) Vera Huang et al.   NUCLEIC ACIDS RESEARCH

Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters

(2011) Scott T. Younger et al.   NUCLEIC ACIDS RESEARCH

Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans

(2011) N. O. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Candida albicans Dicer (CaDcr1) is required for efficient ribosomal and spliceosomal RNA maturation

(2011) D. A. Bernstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Retention of Fission Yeast Dicer Is a Prerequisite for RNAi-Mediated Heterochromatin Assembly

(2010) Stephan Emmerth et al.   DEVELOPMENTAL CELL

Canonical and alternate functions of the microRNA biogenesis machinery

(2010) M. M. W. Chong et al.   GENES & DEVELOPMENT

Diverse Endonucleolytic Cleavage Sites in the Mammalian Transcriptome Depend upon MicroRNAs, Drosha, and Additional Nucleases

(2010) Fedor V. Karginov et al.   MOLECULAR CELL

Crosstalk between mRNA 3′ End Processing and Transcription Initiation

(2010) Christophe K. Mapendano et al.   MOLECULAR CELL

Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription

(2010) Shouhong Guang et al.   NATURE

An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation

(2010) Zhihuan Gao et al.   NATURE

Dicer associates with chromatin to repress genome activity in Schizosaccharomyces pombe

(2010) Katrina J Woolcock et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I

(2010) Priscilla Braglia et al.   NUCLEIC ACIDS RESEARCH

Analysis of Escherichia coli RNase E and RNase III activity in vivo using tiling microarrays

(2010) Mark B. Stead et al.   NUCLEIC ACIDS RESEARCH

Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs

(2010) Markus Brameier et al.   NUCLEIC ACIDS RESEARCH

Dicer Is Associated with Ribosomal DNA Chromatin in Mammalian Cells

(2010) Lasse Sinkkonen et al.   PLoS One

Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease

(2010) A. Nakagawa et al.   SCIENCE

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

(2010) D. Cifuentes et al.   SCIENCE

Making RISC

(2010) Tomoko Kawamata et al.   TRENDS IN BIOCHEMICAL SCIENCES

Posttranscriptional Crossregulation between Drosha and DGCR8

(2009) Jinju Han et al.   CELL

Transcriptional Termination Enhances Protein Expression in Human Cells

(2009) Steven West et al.   MOLECULAR CELL

Fail-Safe Transcriptional Termination for Protein-Coding Genes in S. cerevisiae

(2009) Ana G. Rondón et al.   MOLECULAR CELL

qiRNA is a new type of small interfering RNA induced by DNA damage

(2009) Heng-Chi Lee et al.   NATURE

RNA polymerase V transcription guides ARGONAUTE4 to chromatin

(2009) Andrzej T Wierzbicki et al.   NATURE GENETICS

Genome-wide identification of targets of the drosha-pasha/DGCR8 complex

(2009) S. Kadener et al.   RNA

Small RNAs derived from snoRNAs

(2009) R. J. Taft et al.   RNA

Rejoice--RNAi for Yeast

(2009) D. Moazed   SCIENCE

RNAi in Budding Yeast

(2009) I. A. Drinnenberg et al.   SCIENCE

Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation

(2009) Jamy C. Peng et al.   PLoS Genetics

Cohesin Complex Promotes Transcriptional Termination between Convergent Genes in S. pombe

(2008) Monika Gullerova et al.   CELL

Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes

(2008) Andrzej T. Wierzbicki et al.   CELL

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

A Human snoRNA with MicroRNA-Like Functions

(2008) Christine Ender et al.   MOLECULAR CELL

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

(2008) Toshiaki Watanabe et al.   NATURE

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

(2008) Oliver H. Tam et al.   NATURE

Endogenous small interfering RNAs in animals

(2008) Katsutomo Okamura et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin

(2008) Ke Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Argonaute Transports siRNAs from the Cytoplasm to the Nucleus

(2008) S. Guang et al.   SCIENCE