Costunolide enhances sensitivity of K562/ADR chronic myeloid leukemia cells to doxorubicin through PI3K/Akt pathway

In vitro anti-leukemia activity of dual PI3K/mTOR inhibitor Voxtalisib on HL60 and K562 cells, as well as their multidrug resistance counterparts HL60/ADR and K562/A02 cells

(2018) Lei Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer

(2018) Weishan Zhuge et al.   CANCER LETTERS

Costunolide promotes imatinib-induced apoptosis in chronic myeloid leukemia cells via the Bcr/Abl-Stat5 pathway

(2018) Hong Cai et al.   PHYTOTHERAPY RESEARCH

Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells

(2018) Min Hu et al.   GENE

Mechanisms of Resistance to ABL Kinase Inhibition in Chronic Myeloid Leukemia and the Development of Next Generation ABL Kinase Inhibitors

(2017) Ami B. Patel et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Combined inhibition of β-catenin and Bcr–Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo

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Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia

(2017) Meenu Kesarwani et al.   NATURE MEDICINE

Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway

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Treatment of chronic myelogenous leukemia

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The apoptotic members CD95, BclxL and Bcl-2 cooperate to promote cell migration by inducing Ca2+ flux from the endoplasmic reticulum to mitochondria

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BCR/ABL oncogene-induced PI3K signaling pathway leads to chronic myeloid leukemia pathogenesis by impairing immuno-modulatory function of hemangioblasts

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Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice

(2015) Carolina Vicente-Dueñas et al.   Oncotarget

Growth Inhibition Effects of Isoalantolactone on K562/A02 Cells: Caspase-dependent Apoptotic Pathways, S Phase Arrest, and Downregulation of Bcr/Abl

(2014) Hong Cai et al.   PHYTOTHERAPY RESEARCH

The Role of Mitochondrial DNA Damage and Repair in the Resistance of BCR/ABL-Expressing Cells to Tyrosine Kinase Inhibitors

(2013) Sylwester Glowacki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY