The Role of Mitochondrial DNA Damage and Repair in the Resistance of BCR/ABL-Expressing Cells to Tyrosine Kinase Inhibitors

Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy

(2015) Jean-Claude Chomel et al.   Oncotarget

Characterization and prognostic significance of mitochondrial DNA variations in acute myeloid leukemia

(2013) Trine Silkjaer et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Mitochondrial genome depletion in human liver cells abolishes bile acid-induced apoptosis: Role of the Akt/mTOR survival pathway and Bcl-2 family proteins

(2013) Jose J.G. Marin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial and Nuclear DNA Damage and Repair in Age-Related Macular Degeneration

(2013) Janusz Blasiak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BCR-ABL1 RT-qPCR for Monitoring the Molecular Response to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

(2013) Richard D. Press et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

(2012) M. Nieborowska-Skorska et al.   BLOOD

Generation, function and diagnostic value of mitochondrial DNA copy number alterations in human cancers

(2011) Man Yu   LIFE SCIENCES

Exploiting Mitochondrial Dysfunction for Effective Elimination of Imatinib-Resistant Leukemic Cells

(2011) Jérome Kluza et al.   PLoS One

Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway

(2010) Tetsuya Kurosu et al.   APOPTOSIS

Apoptogenic factors released from mitochondria

(2010) David L. Vaux   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Aerobic Glycolysis Suppresses p53 Activity to Provide Selective Protection from Apoptosis upon Loss of Growth Signals or Inhibition of BCR-Abl

(2010) E. F. Mason et al.   CANCER RESEARCH

Mitochondrial DNA repair and association with aging – An update

(2010) Ricardo Gredilla et al.   EXPERIMENTAL GERONTOLOGY

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic myeloid leukemia: mechanisms of blastic transformation

(2010) Danilo Perrotti et al.   JOURNAL OF CLINICAL INVESTIGATION

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

(2010) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming

(2010) F Zhao et al.   ONCOGENE

BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase C 

(2009) F. Pellicano et al.   BLOOD

Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study

(2009) J Klawitter et al.   BRITISH JOURNAL OF CANCER

Sorafenib Induces Apoptosis Specifically in Cells Expressing BCR/ABL by Inhibiting Its Kinase Activity to Activate the Intrinsic Mitochondrial Pathway

(2009) T. Kurosu et al.   CANCER RESEARCH

Abnormalities in Glucose Uptake and Metabolism in Imatinib-Resistant Human BCR-ABL-Positive Cells

(2009) D. J. Kominsky et al.   CLINICAL CANCER RESEARCH

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

(2009) Nadja C. de Souza-Pinto et al.   DNA REPAIR

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

(2009) J. S. Park et al.   HUMAN MOLECULAR GENETICS

Translation of the Philadelphia chromosome into therapy for CML

(2008) B. J. Druker   BLOOD

A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

(2008) Q. Lan et al.   BLOOD

Transient Potent BCR-ABL Inhibition Is Sufficient to Commit Chronic Myeloid Leukemia Cells Irreversibly to Apoptosis

(2008) Neil P. Shah et al.   CANCER CELL

DNA-damage repair; the good, the bad, and the ugly

(2008) Razqallah Hakem   EMBO JOURNAL

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

(2008) H Zhang et al.   LEUKEMIA

Reversible regulation of metastasis by ROS-generating mtDNA mutations

(2008) Kaori Ishikawa et al.   MITOCHONDRION

Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

(2008) P. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells

(2008) John G. Albeck et al.   MOLECULAR CELL

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY