Costunolide promotes imatinib-induced apoptosis in chronic myeloid leukemia cells via the Bcr/Abl-Stat5 pathway

Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways

(2017) Hong Cai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Influence of MDR1 and CYP3A5 genetic polymorphisms on trough levels and therapeutic response of imatinib in newly diagnosed patients with chronic myeloid leukemia

(2017) Natarajan Harivenkatesh et al.   PHARMACOLOGICAL RESEARCH

Imatinib mesylate inhibits STAT5 phosphorylation in response to IL-7 and promotes T cell lymphopenia in chronic myelogenous leukemia patients

(2017) S Thiant et al.   Blood Cancer Journal

The therapeutic potential of cell cycle targeting in multiple myeloma

(2017) Anke Maes et al.   Oncotarget

Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway

(2017) Zhangxiao Peng et al.   Scientific Reports

Enhanced targeting of CML stem and progenitor cells by inhibition of porcupine acyltransferase in combination with TKI

(2016) Puneet Agarwal et al.   BLOOD

Bcr-abl regulates Stat5 through Shp2, the interferon consensus sequence binding protein (Icsbp/Irf8), growth arrest specific 2 (Gas2) and calpain

(2016) Elizabeth E. Hjort et al.   Oncotarget

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2–dependent adult T-cell leukemia

(2015) Meili Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo

(2014) P. Gallipoli et al.   BLOOD

PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis

(2013) A Berger et al.   LEUKEMIA

Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036

(2011) Wayne W. Chan et al.   CANCER CELL

Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231

(2011) Youn Kyung Choi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation

(2011) Elena Butturini et al.   PLoS One

A Specific Need for CRKL in p210BCR-ABL-Induced Transformation of Mouse Hematopoietic Progenitors

(2010) J.-H. Seo et al.   CANCER RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Costunolide-Induced Apoptosis in Human Leukemia Cells: Involvement of c-Jun N-Terminal Kinase Activation

(2009) Jung-Hye Choi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN