TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

Triggering receptor expressed on myeloid cells 2 (TREM2): a potential therapeutic target for Alzheimer disease?

(2018) Yuetiva Deming et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Assessment of the Genetic Architecture of Alzheimer’s Disease Risk in Rate of Memory Decline

(2018) Jorge L. Del-Aguila et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular basis for the loss-of-function effects of the Alzheimer’s disease–associated R47H variant of the immune receptor TREM2

(2018) Athena Sudom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

(2018) Wilbur M. Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

(2018) Paul J. Cheng-Hathaway et al.   Molecular Neurodegeneration

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

(2018) Zeran Li et al.   Genome Medicine

Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease

(2018) Maria V. Fernández et al.   Frontiers in Neuroscience

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

(2018) Xianyuan Xiang et al.   Molecular Neurodegeneration

Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

(2018) Hiroyuki Konishi et al.   Frontiers in Cellular Neuroscience

Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis

(2017) Bruno A. Benitez et al.   Scientific Reports

Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease

(2017) Maria Victoria Fernández et al.   PLoS Genetics

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

(2016) Laura Piccio et al.   ACTA NEUROPATHOLOGICA

SORL1 variants across Alzheimer’s disease European American cohorts

(2016) Maria Victoria Fernández et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

(2016) Li Ma et al.   Molecular Neurodegeneration

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Progesterone exerts neuroprotective effects and improves long-term neurologic outcome after intracerebral hemorrhage in middle-aged mice

(2016) Chao Jiang et al.   NEUROBIOLOGY OF AGING

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

(2016) Naiara Celarain et al.   Clinical Epigenetics

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation

(2016) Huaili Jiang et al.   Scientific Reports

The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

(2015) Panos Roussos et al.   Alzheimers & Dementia

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

(2015) Christina M. Lill et al.   Alzheimers & Dementia

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Association Study of the TREM2 Gene and Identification of a Novel Variant in Exon 2 in Iranian Patients with Late-Onset Alzheimer's Disease

(2015) Zohreh Mehrjoo et al.   MEDICAL PRINCIPLES AND PRACTICE

TREM2 analysis and increased risk of Alzheimer's disease

(2015) Deana Finelli et al.   NEUROBIOLOGY OF AGING

More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk

(2015) Samantha L. Rosenthal et al.   NEUROBIOLOGY OF AGING

R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

(2014) Catherine F. Slattery et al.   Alzheimers & Dementia

Coding variants in TREM2 increase risk for Alzheimer's disease

(2014) Sheng Chih Jin et al.   HUMAN MOLECULAR GENETICS

Erratum to “Exploratory analysis of seven Alzheimer's disease genes: disease progression” [Neurobiol. Aging 34 (2013) 1310.e1–1310.e7]

(2014) Agustín Ruiz et al.   NEUROBIOLOGY OF AGING

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

(2013) Patrick Wunderlich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

(2013) Margarita Giraldo et al.   NEUROBIOLOGY OF AGING

TREM2 is associated with the risk of Alzheimer's disease in Spanish population

(2013) Bruno A. Benitez et al.   NEUROBIOLOGY OF AGING

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

(2013) Elise Cuyvers et al.   NEUROBIOLOGY OF AGING

Missense variant in TREML2 protects against Alzheimer's disease

(2013) Bruno A. Benitez et al.   NEUROBIOLOGY OF AGING

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation

(2008) Laura Piccio et al.   BRAIN

Developmental Regulation of TREM2 and DAP12 Expression in the Murine CNS: Implications for Nasu-Hakola Disease

(2008) J. Cameron Thrash et al.   NEUROCHEMICAL RESEARCH