Article
Immunology
Shuwen Deng, Xiqian Chen, Qiang Lei, Wei Lu
Summary: The decrease of serum AQP2 levels after intracerebral hemorrhage (ICH) is negatively correlated with poor prognosis, indicating it may be a marker of early-stage inflammation. AQP2 overexpression promotes astrocyte activation and pro-inflammatory secretion, affects astrocyte-microglia crosstalk, and indirectly induces microglial polarization, which may augment inflammation after ICH.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Yan Huang, Chenxu Zhao, Yaoquan Liu, Yezi Kong, Panpan Tan, Siqi Liu, Fangyuan Zeng, Yang Yuan, Xinwei Li, Guowen Liu, Baoyu Zhao, Jianguo Wang
Summary: The study shows that NEFA can activate hepatocyte autophagy through the PERK pathway, contributing to lipid metabolism. These findings enhance our understanding of energy redistribution and utilization during the perinatal period of dairy cows.
Article
Biochemistry & Molecular Biology
Zihou Cao, Gongwen Liu, Hui Zhang, Mingyong Wang, Youjia Xu
Summary: This study investigates the role of Nox4 in early bone development and finds that Nox4 deletion leads to reduced bone mineralization and significantly decreased numbers of osteoblasts, osteoclasts, and chondrocytes. The study also reveals disruption of the TGF-beta signaling pathway in the absence of Nox4, and demonstrates that inhibiting this signaling pathway rescues the abnormal bone development and increases the number of osteoblasts.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ding Wang, Yapu Li, Changlu Xu, Hongtao Wang, Xin Huang, Xu Jin, Sirui Ren, Jie Gao, Jingyuan Tong, Jinhua Liu, Jiaxi Zhou, Lihong Shi
Summary: The role of SETD7 in human hematopoietic development is not well understood. In this study, it was found that deletion of SETD7 attenuated the generation of hematopoietic progenitor cells from human embryonic stem cells. Further investigation revealed that SETD7 was required for lateral plate mesoderm specification, but not essential for the generation of endothelial progenitor cells and hematopoietic progenitor cells. Mechanistically, SETD7 interacted with beta-catenin to facilitate its degradation, independently of its histone methyltransferase activity. Decreased SETD7 expression led to the accumulation of beta-catenin and activation of the Wnt signaling pathway, resulting in altered mesoderm patterning.
Article
Pharmacology & Pharmacy
Dali Gan, Qiyuan Su, Hanwen Su, Li Wu, Jun Chen, Bing Han, Meixian Xiang
Summary: The study demonstrates the safety and efficacy of burn ointment in promoting wound healing and suggests that the activation of the PI3K/AKT/mTOR signaling pathway may play an important role in this process.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Jianxin Xu, Xuejiao Fang, Luye Long, Sixuan Wang, Shihan Qian, Jianxin Lyu
Summary: This study found that HMGA2 is highly expressed in TNBC cells, and downregulation of HMGA2 inhibits the migration and invasion of TNBC, as well as tumor metastasis in vivo, through suppression of EMT and the Hippo-YAP pathway.
CANCER BIOLOGY & THERAPY
(2021)
Article
Genetics & Heredity
Qian Zhang, Jun Dan, Shuang Meng, Yingjie Li, Jing Li
Summary: This study investigated the role of Toll-like receptor 4 (TLR4) in autophagy and proliferation in gastric cancer (GC) cells. The levels of TLR4 were determined in different stages of GC cells/tissues using RT-qPCR and WB, along with the levels of autophagy-related proteins (ARPs) and the underlying signaling mechanism. Proliferation was assessed using the CCK-8 assay. The results revealed that modulation of the PI3K/AKT/mTOR pathway was induced by the overexpression and knockdown of TLR4, leading to inhibition/induction of autophagy, and TLR4 played a vital role in GC progression.
Review
Biochemistry & Molecular Biology
Yongguang Gao, Na Chen, Zhanda Fu, Qing Zhang
Summary: Osteoporosis is a serious health disease characterized by bone mass loss, bone density reduction, and degeneration of bone microstructure, leading to bone fragility and a higher risk of fracture. More than 200 million people worldwide suffer from this condition, with estimated treatment costs of at least $25 billion by 2025. The Wnt signaling pathway plays a crucial role in bone development, metabolism, and the differentiation and proliferation of bone-related cells. Inhibitory proteins Dkk-1 and SOST, which block the activation of the canonical Wnt signaling pathway, have potential as targets for osteoporosis treatment. This review provides an analysis of the mechanisms of Wnt proteins, beta-catenin, and signaling molecules, highlighting the importance of the Wnt signaling pathway in osteoporosis and offering new perspectives and approaches for diagnosis and treatment.
Article
Oncology
Zongmeng Zhang, Jinlin Du, Qihua Xu, Yuyu Li, Sujin Zhou, Zhenggang Zhao, Yunping Mu, Allan Z. Zhao, Su-Mei Cao, Fanghong Li
Summary: Chronic inflammation is associated with the development of nasopharyngeal carcinoma (NPC), where resistin, an inflammatory cytokine, plays a role in promoting tumor metastasis. High resistin levels in NPC patients are positively correlated with lymph node metastasis, and resistin induces epithelial-mesenchymal transition (EMT) to facilitate metastasis. The TLR4/p38 MAPK/NF-kappa B signaling pathways are involved in resistin-mediated promotion of NPC metastasis.
Article
Biotechnology & Applied Microbiology
Qiteng Ding, Wencong Liu, Xinglong Liu, Chuanbo Ding, Yingchun Zhao, Ling Dong, Huiying Chen, Shuwen Sun, Yiwen Zhang, Jinping Zhang, Ming Wu
Summary: In this study, polyvinylpyrrolidone-k30 modified taxifolin liposomes were successfully prepared, and their particle size, zeta potential, polydispersity coefficient, and drug loading efficiency were studied. The results of in vitro release experiments showed high drug release rates for the modified liposomes in simulated gastric fluid and simulated intestinal fluid. Additionally, the modified liposomes were able to reverse acute liver injury and inhibit the expression of inflammatory factors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jin Lei, Peng Xiang, Shengmei Zeng, Le Chen, Lei Zhang, Zhiyi Yuan, Jun Zhang, Tingting Wang, Ruihong Yu, Wanping Zhang, Issa Issoufou Ibrahim, Limei Ma, Chao Yu
Summary: This study investigated the molecular mechanism of tetramethylpyrazine (TMP) on vascular endothelial glycocalyx in an inflammatory model. The results showed that TMP protected endothelial glycocalyx integrity by inhibiting its degradation and monocyte adhesion to the endothelium. This protective effect was mediated through the TLR4/NF-kappa B/HPSE1 signaling pathway. TMP could be considered as a novel strategy for protecting endothelial glycocalyx and potentially preventing atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Chen Zhang, Min Chen, Qi Tao, Zhangcai Chi
Summary: Hypoxia induces proliferation of cholesteatoma keratinocytes through upregulating p-PDK1 and p-Akt expressions via the PI3K-Akt signaling cascade. Inhibition of p-Akt expression by specific inhibitor LY294002 significantly reduces hypoxia-induced cell proliferation in cholesteatoma keratinocytes. This study provides evidence supporting the involvement of hypoxia in cholesteatoma initiation and progression.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Juping Wang, Haoming Hua, Fanlu Wang, Shuling Yang, Qinghong Zhou, Xiangsheng Wu, Ding Feng, Hui Peng
Summary: This study identified the critical role of PRMT2 and protein arginine methylation in enhancing IFN-beta production via the TLR4/IRF3 signaling pathway, offering a potential therapeutic strategy for controlling endotoxemia.
MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Jiyun Choi, Seoyeon Gang, Mahesh Ramalingam, Jinsu Hwang, Haewon Jeong, Jin Yoo, Hyong-Ho Cho, Byeong C. Kim, Geupil Jang, Han-Seong Jeong, Sujeong Jang
Summary: The HDAC inhibitor BML-281 promotes the differentiation of SH-SY5Y neuroblastoma cells into mature neurons. Treatment with BML-281 leads to neurite outgrowth and morphological changes, as well as increased expression of neuronal markers at both the gene and protein level. BML-281 activates the non-canonical Wnt signaling pathway to induce differentiation.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Article
Cell Biology
Huaili Jiang, Lei Zhou, Na Shen, Xianhui Ning, Daquan Wu, Kanglun Jiang, Xinsheng Huang
Summary: This study revealed that M1-derived exosomes containing HOTTIP activate the TLR5/NF-kappa B signaling pathway by competitively sponging miR-19a-3p and miR-19b-3p, thereby suppressing the progression of head and neck squamous cell carcinoma (HNSCC). Additionally, M1-derived exosomes and HOTTIP induce the polarization of circulating monocytes towards an M1 phenotype, providing new insights into HNSCC immunotherapy.
CELL DEATH & DISEASE
(2022)
Article
Audiology & Speech-Language Pathology
Yu Si, Huai Li Jiang, Yu Bin Chen, Yu Guo Chu, Sui Jun Chen, Xi Ming Chen, Wu Hui He, Yi Qing Zheng, Zhi Gang Zhang
AUDIOLOGY AND NEURO-OTOLOGY
(2018)