TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer’s disease progression: CX3CL1, TREM2, and PPARγ

(2015) S. Strobel et al.   JOURNAL OF NEURAL TRANSMISSION

Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

(2015) Henna Martiskainen et al.   NEUROBIOLOGY OF AGING

What happens to microglial TREM2 in Alzheimer’s disease: Immunoregulatory turned into immunopathogenic?

(2015) L.-F. Lue et al.   NEUROSCIENCE

R47H Variant ofTREM2Associated With Alzheimer Disease in a Large Late-Onset Family

(2015) Olena Korvatska et al.   JAMA Neurology

TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices

(2014) Lih-Fen Lue et al.   BRAIN PATHOLOGY

Age-Related Increase in Levels of 5-Hydroxymethylcytosine in Mouse Hippocampus is Prevented by Caloric Restriction

(2014) Leonidas Chouliaras et al.   Current Alzheimer Research

5-Hydroxymethylation marks a class of neuronal gene regulated by intragenic methylcytosine levels

(2014) Rachelle E. Irwin et al.   GENOMICS

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer’s Disease

(2014) Zainularifeen Abduljaleel et al.   PLoS One

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Aluminum-Induced Amyloidogenesis and Impairment in the Clearance of Amyloid Peptides from the Central Nervous System in Alzheimer’s Disease

(2014) Yuhai Zhao et al.   Frontiers in Neurology

TREM2 and the neuroimmunology of Alzheimer's disease

(2013) Suzanne E. Hickman et al.   BIOCHEMICAL PHARMACOLOGY

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

(2013) Y Tang et al.   CELL DEATH AND DIFFERENTIATION

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Insights into TREM2 biology by network analysis of human brain gene expression data

(2013) Paola Forabosco et al.   NEUROBIOLOGY OF AGING

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Increased 5-Methylcytosine and Decreased 5-Hydroxymethylcytosine Levels are Associated with Reduced Striatal A2AR Levels in Huntington’s Disease

(2013) Izaskun Villar-Menéndez et al.   NEUROMOLECULAR MEDICINE

Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a

(2013) Yuhai Zhao et al.   NEUROREPORT

Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity

(2013) Bradley M. Colquitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System

(2012) Marian Mellén et al.   CELL

Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression

(2012) S. A. Selamat et al.   GENOME RESEARCH

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

(2011) H. Wu et al.   GENES & DEVELOPMENT

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

(2010) Martin Münzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

(2009) Luisa Stefano et al.   JOURNAL OF NEUROCHEMISTRY

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Management of a twenty-first century brain bank: experience in the BrainNet Europe consortium

(2008) Jeanne E. Bell et al.   ACTA NEUROPATHOLOGICA

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA

QUMA: quantification tool for methylation analysis

(2008) Y. Kumaki et al.   NUCLEIC ACIDS RESEARCH