The AAA+ATPase RUVBL2 is essential for the oncogenic function of c-MYB in acute myeloid leukemia

A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia

(2018) Yali Xu et al.   CANCER CELL

Peptidomimetic blockade of MYB in acute myeloid leukemia

(2018) Kavitha Ramaswamy et al.   Nature Communications

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

(2018) Alba Maiques-Diaz et al.   Cell Reports

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

(2018) Xiaorong Gu et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor suppressors BTG1 and BTG2: Beyond growth control

(2018) Laurensia Yuniati et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting acute myeloid leukemia by drug-induced c-MYB degradation

(2017) V Walf-Vorderwülbecke et al.   LEUKEMIA

MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia

(2017) K H M Prange et al.   ONCOGENE

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

(2016) David B. Sykes et al.   CELL

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs

(2016) Amit Mandoli et al.   Cell Reports

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

(2016) Konstantinos Tzelepis et al.   Cell Reports

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

(2015) Sagar Uttarkar et al.   BLOOD

Emerging strategies for high-risk and relapsed/refractory acute myeloid leukemia: Novel agents and approaches currently in clinical trials

(2015) Joshua P. Sasine et al.   BLOOD REVIEWS

Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression

(2015) Amy Tarangelo et al.   Nature Communications

Chromatin modifiers and the promise of epigenetic therapy in acute leukemia

(2014) S M Greenblatt et al.   LEUKEMIA

STAT3 mediates oncogenic addiction to TEL-AML1 in t(12;21) acute lymphoblastic leukemia

(2013) M. Mangolini et al.   BLOOD

The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis

(2013) H Osaki et al.   LEUKEMIA

Genetic Interaction between Mutations in c-Myb and the KIX Domains of CBP and p300 Affects Multiple Blood Cell Lineages and Influences Both Gene Activation and Repression

(2013) Lawryn H. Kasper et al.   PLoS One

Retinoic acid and tumor necrosis factor-α induced monocytic cell gene expression is regulated in part by induction of transcription factor MafB

(2012) Y. Zhang et al.   EXPERIMENTAL CELL RESEARCH

Role and potential for therapeutic targeting of MYB in leukemia

(2012) D R Pattabiraman et al.   LEUKEMIA

Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study

(2011) H. Kang et al.   BLOOD

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

(2011) Ching-Hon Pui et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb

(2011) Liang Zhao et al.   NUCLEIC ACIDS RESEARCH

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

(2010) Shenghao Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

(2009) R. W. Stam et al.   BLOOD

Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes

(2009) M J Woodward et al.   CELL DEATH AND DIFFERENTIATION

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients

(2009) Luca Trentin et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

(2009) Harukazu Suzuki et al.   NATURE GENETICS

Regulatory interdependence of myeloid transcription factors revealed by Matrix RNAi analysis

(2009) Yasuhiro Tomaru et al.   GENOME BIOLOGY

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

(2008) S. J. Horton et al.   BLOOD

Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

(2008) Andrew S. Venteicher et al.   CELL

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY