More than the sum of the parts: Toward full‐length receptor tyrosine kinase structures

Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor

(2018) Theresia Gutmann et al.   JOURNAL OF CELL BIOLOGY

Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras

(2018) Samantha I. Liang et al.   Cell Reports

Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

(2018) Jeroen Claus et al.   eLife

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

(2018) Giovanna Scapin et al.   NATURE

The signalling conformation of the insulin receptor ectodomain

(2018) Felix Weis et al.   Nature Communications

EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms

(2017) Bettina van Lengerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback regulation of RTK signaling in development

(2017) Cynthia L. Neben et al.   DEVELOPMENTAL BIOLOGY

Structural and biochemical studies of the PDGFRA kinase domain

(2016) Ling Liang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

(2016) Sarah R. Needham et al.   Nature Communications

Molecular basis for multimerization in the activation of the epidermal growth factor receptor

(2016) Yongjian Huang et al.   eLife

A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   Annual Review of Biochemistry

Role of GxxxG Motifs in Transmembrane Domain Interactions

(2015) Mark G. Teese et al.   BIOCHEMISTRY

Growth Factor Identity Is Encoded by Discrete Coiled-Coil Rotamers in the EGFR Juxtamembrane Region

(2015) Amy Doerner et al.   CHEMISTRY & BIOLOGY

Membrane protein structures without crystals, by single particle electron cryomicroscopy

(2015) Kutti R Vinothkumar   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of Full-Length Human PDGFRβ Bound to Its Activating Ligand PDGF-B as Determined by Negative-Stain Electron Microscopy

(2015) Po-Han Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

The Strength and Cooperativity of KIT Ectodomain Contacts Determine Normal Ligand-Dependent Stimulation or Oncogenic Activation in Cancer

(2015) Andrey V. Reshetnyak et al.   MOLECULAR CELL

How cryo-EM is revolutionizing structural biology

(2015) Xiao-chen Bai et al.   TRENDS IN BIOCHEMICAL SCIENCES

The insulin and IGF1 receptor kinase domains are functional dimers in the activated state

(2015) M. Zulema Cabail et al.   Nature Communications

Solution structure of the transmembrane domain of the insulin receptor in detergent micelles

(2014) Qingxin Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

(2014) Carlos L. Arteaga et al.   CANCER CELL

Molecular pathologic diagnosis of epidermal growth factor receptor

(2014) C. L. Maire et al.   NEURO-ONCOLOGY

Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers

(2014) Yarden Opatowsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations

(2014) P. Littlefield et al.   Science Signaling

Membrane Interaction of Bound Ligands Contributes to the Negative Binding Cooperativity of the EGF Receptor

(2014) Anton Arkhipov et al.   PLoS Computational Biology

How IGF-1 activates its receptor

(2014) Jennifer M Kavran et al.   eLife

The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

(2013) Colin W. Ward et al.   BIOESSAYS

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase

(2013) S. R. Hubbard   Cold Spring Harbor Perspectives in Biology

Bipartite Tetracysteine Display Reveals Allosteric Control of Ligand-Specific EGFR Activation

(2012) Rebecca A. Scheck et al.   ACS Chemical Biology

Platelet-derived growth factors and their receptors: Structural and functional perspectives

(2012) Po-Han Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families

(2012) Colin W Ward et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hydrophobic Matching Controls the Tilt and Stability of the Dimeric Platelet-derived Growth Factor Receptor (PDGFR) β Transmembrane Segment

(2012) Claudia Muhle-Goll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor

(2012) Chafen Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Finding the missing links in EGFR

(2012) Nicholas J Bessman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2

(2012) H. Greulich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activating HER2 Mutations in HER2 Gene Amplification Negative Breast Cancer

(2012) Ron Bose et al.   Cancer Discovery

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

(2011) K. Verstraete et al.   BLOOD

Insulin Receptor-Related Receptor as an Extracellular Alkali Sensor

(2011) Igor E. Deyev et al.   Cell Metabolism

Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

(2011) Natalia Jura et al.   MOLECULAR CELL

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor

(2011) Li-Zhi Mi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic insights into the activation of oncogenic forms of EGF receptor

(2011) Zhihong Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor

(2010) C. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distribution of resting and ligand-bound ErbB1 and ErbB2 receptor tyrosine kinases in living cells using number and brightness analysis

(2010) P. Nagy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor tyrosine kinase transmembrane domains

(2010) Edwin Li et al.   Cell Adhesion & Migration

Strong oligomerization behavior of PDGFβ receptor transmembrane domain and its regulation by the juxtamembrane regions

(2009) Joanne Oates et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia

(2009) S. Meshinchi et al.   CLINICAL CANCER RESEARCH

Her4 and Her2/neu Tyrosine Kinase Domains Dimerize and Activate in a Reconstitutedin VitroSystem

(2009) John Monsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of Ectodomains of the Insulin Receptor Family: The Ectodomain of the Type 1 Insulin-Like Growth Factor Receptor Displays Asymmetry of Ligand Binding Accompanied by Limited Conformational Change

(2009) Andrew E. Whitten et al.   JOURNAL OF MOLECULAR BIOLOGY

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

(2009) Monica Red Brewer et al.   MOLECULAR CELL

ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor

(2009) Diego Alvarado et al.   NATURE

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

(2009) N. Jura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites†

(2008) Linda Whittaker et al.   BIOCHEMISTRY

Functional and Structural Stability of the Epidermal Growth Factor Receptor in Detergent Micelles and Phospholipid Nanodiscs†

(2008) Li-Zhi Mi et al.   BIOCHEMISTRY

Predominance of activated EGFR higher-order oligomers on the cell surface

(2008) Andrew H. A. Clayton et al.   GROWTH FACTORS

Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

(2008) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase

(2008) Chen Qiu et al.   STRUCTURE