The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Similar but different: ligand-induced activation of the insulin and epidermal growth factor receptor families

(2012) Colin W Ward et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

 -Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

(2012) J. Whittaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms

(2011) Louise Knudsen et al.   BIOCHEMICAL JOURNAL

Insulin Receptor-Related Receptor as an Extracellular Alkali Sensor

(2011) Igor E. Deyev et al.   Cell Metabolism

Structural Analysis of Macromolecular Assemblies by Electron Microscopy

(2011) E. V. Orlova et al.   CHEMICAL REVIEWS

Fine Details of IGF-1R Activation, Inhibition, and Asymmetry Determined by Associated Hydrogen /Deuterium-Exchange and Peptide Mass Mapping

(2011) Damian Houde et al.   STRUCTURE

Landmarks in Insulin Research

(2011) Colin W. Ward et al.   Frontiers in Endocrinology

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

(2010) J. Jiracek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

(2009) Colin W. Ward et al.   BIOESSAYS

A Novel Approach to Identify Two Distinct Receptor Binding Surfaces of Insulin-like Growth Factor II

(2009) Clair L. Alvino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decoding the Cryptic Active Conformation of a Protein by Synthetic Photoscanning

(2009) Bin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of Ectodomains of the Insulin Receptor Family: The Ectodomain of the Type 1 Insulin-Like Growth Factor Receptor Displays Asymmetry of Ligand Binding Accompanied by Limited Conformational Change

(2009) Andrew E. Whitten et al.   JOURNAL OF MOLECULAR BIOLOGY

Importance of the Solvent-Exposed Residues of the Insulin B Chain α-Helix for Receptor Binding†

(2008) Tine Glendorf et al.   BIOCHEMISTRY

High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites†

(2008) Linda Whittaker et al.   BIOCHEMISTRY

Alanine Scanning of a Putative Receptor Binding Surface of Insulin-like Growth Factor-I

(2008) Lisbeth Gauguin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Comparative Structural Bioinformatics Analysis of the Insulin Receptor Family Ectodomain Based on Phylogenetic Information

(2008) Miguel E. Rentería et al.   PLoS One

N-linked glycans of the human insulin receptor and their distribution over the crystal structure

(2007) Lindsay G. Sparrow et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS