Targeting Apolipoprotein E for Alzheimer’s Disease: An Industry Perspective

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

(2019) Changjun Yin et al.   NATURE MEDICINE

Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1

(2019) Michael R. Strickland et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood will out: vascular contributions to Alzheimer’s disease

(2018) Sidney Strickland   JOURNAL OF CLINICAL INVESTIGATION

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

(2018) Fan Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease

(2018) Brad T. Casali et al.   Journal of Neuroinflammation

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

(2018) Chengzhong Wang et al.   NATURE MEDICINE

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Class I HDAC inhibition is a novel pathway for regulating astrocytic apoE secretion

(2018) Erica Dresselhaus et al.   PLoS One

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes

(2018) Grégory Operto et al.   Alzheimers Research & Therapy

APOE and AβPP Gene Variation in Cortical and Cerebrovascular Amyloid-β Pathology and Alzheimer's Disease: A Population-Based Analysis

(2018) Terhi Peuralinna et al.   JOURNAL OF ALZHEIMERS DISEASE

Improvement of Memory Deficits and Amyloid-β Clearance in Aged APP23 Mice Treated with a Combination of Anti-Amyloid-β Antibody and LXR Agonist

(2018) Nicholas F. Fitz et al.   JOURNAL OF ALZHEIMERS DISEASE

Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

(2018) Kenzo Koizumi et al.   Nature Communications

The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives

(2018) Cody Wolfe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

(2018) Xunde Xian et al.   eLife

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

(2017) Jing Zhao et al.   HUMAN MOLECULAR GENETICS

ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice

(2017) Nicholas F. Fitz et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of APOE on lipid homeostasis and inflammation in normal brains

(2017) G. William Rebeck   JOURNAL OF LIPID RESEARCH

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

(2017) Tien-Phat V. Huynh et al.   NEURON

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

(2017) Na Zhao et al.   NEURON

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice

(2016) Jérôme Robert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2016) Yu Yamazaki et al.   CNS DRUGS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies

(2016) Anat Boehm-Cagan et al.   JOURNAL OF ALZHEIMERS DISEASE

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice

(2016) C. Lane-Donovan et al.   JOURNAL OF NEUROSCIENCE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Influence of APOE Genotype on Hippocampal Atrophy over Time - An N=1925 Surface-Based ADNI Study

(2016) Bolun Li et al.   PLoS One

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

(2016) Won-Suk Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

(2016) Jianjia Fan et al.   PLoS One

Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele

(2015) Sana Suri et al.   Alzheimers & Dementia

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease

(2015) Liv Tybjærg Nordestgaard et al.   Alzheimers & Dementia

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

(2015) Charles C. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice

(2015) Angela W. Corona et al.   Journal of Neuroimmune Pharmacology

Apolipoprotein E, Carbon Dioxide Vasoreactivity, and Cognition in Older Adults: Effect of Hypertension

(2015) Ihab Hajjar et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice

(2015) De-shan Liu et al.   Molecular Neurodegeneration

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

(2014) Sophie Stukas et al.   Cell Metabolism

Genetic influence of apolipoprotein E4 genotype on hippocampal morphometry: AnN= 725 surface-based Alzheimer's disease neuroimaging initiative study

(2014) Jie Shi et al.   HUMAN BRAIN MAPPING

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E4 Produced in GABAergic Interneurons Causes Learning and Memory Deficits in Mice

(2014) J. Knoferle et al.   JOURNAL OF NEUROSCIENCE

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

(2014) Angel C. Y. Mak et al.   JAMA Neurology

The APOE ε4/ε4 Genotype Potentiates Vascular Fibrin(Ogen) Deposition in Amyloid-Laden Vessels in the Brains of Alzheimer's Disease Patients

(2013) Karin Hultman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Examination of the Clinicopathologic Continuum of Alzheimer Disease in the Autopsy Cohort of the National Alzheimer Coordinating Center

(2013) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

The Liver X Receptor Agonist GW3965 Improves Recovery from Mild Repetitive Traumatic Brain Injury in Mice Partly through Apolipoprotein E

(2013) Dhananjay R. Namjoshi et al.   PLoS One

Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides

(2013) Angela J. Hanson et al.   JAMA Neurology

APOE genotype alters glial activation and loss of synaptic markers in mice

(2012) Yuangui Zhu et al.   GLIA

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

(2012) Carlos Cruchaga et al.   HUMAN MOLECULAR GENETICS

Small-Molecule Structure Correctors Target Abnormal Protein Structure and Function: Structure Corrector Rescue of Apolipoprotein E4–Associated Neuropathology

(2012) Robert W. Mahley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Liver X receptors regulate cholesterol homeostasis in oligodendrocytes

(2011) Katherine Nelissen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Lipids in Alzheimer's disease: A century-old story

(2010) Paul Foley   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Modulation of ABCA1 by an LXR Agonist Reduces Beta-Amyloid Levels and Improves Outcome after Traumatic Brain Injury

(2010) David J. Loane et al.   JOURNAL OF NEUROTRAUMA

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOE and cholesterol homeostasis in Alzheimer's disease

(2010) Valérie Leduc et al.   TRENDS IN MOLECULAR MEDICINE

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Understanding the Basis for the Association of apoE4 with Alzheimers Disease: Opening the Door for Therapeutic Approaches

(2009) Ning Zhong et al.   Current Alzheimer Research

Reduced levels of human apoE4 protein in an animal model of cognitive impairment

(2009) P.M. Sullivan et al.   NEUROBIOLOGY OF AGING

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

(2008) Suzanne E. Wahrle et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

(2008) D. R. Riddell et al.   JOURNAL OF NEUROSCIENCE