Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease
出版年份 2016 全文链接
标题
Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease
作者
关键词
Clinical trial, Alzheimer’s disease, MRI, Amyloid, PET, Bexarotene, ApoE genotype
出版物
Alzheimers Research & Therapy
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2016-01-28
DOI
10.1186/s13195-016-0173-2
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- 2015 Alzheimer's disease facts and figures
- (2015) Alzheimers & Dementia
- Measurement of Longitudinal -Amyloid Change with 18F-Florbetapir PET and Standardized Uptake Value Ratios
- (2015) S. M. Landau et al. JOURNAL OF NUCLEAR MEDICINE
- Improved Power for Characterizing Longitudinal Amyloid- PET Changes and Evaluating Amyloid-Modifying Treatments with a Cerebral White Matter Reference Region
- (2015) K. Chen et al. JOURNAL OF NUCLEAR MEDICINE
- Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways
- (2015) C. Bohm et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease
- (2014) Daniel M. Michaelson Alzheimers & Dementia
- Emerging Therapeutics for Alzheimer's Disease
- (2014) Karen Chiang et al. Annual Review of Pharmacology and Toxicology
- ENDOCRINE SIDE-EFFECTS OF ANTI-CANCER DRUGS: The impact of retinoids on the thyroid axis
- (2014) Julia Graeppi-Dulac et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway
- (2014) Jing Zhao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid-β Pathology andAPOEGenotype Modulate Retinoid X Receptor Agonist Activityin Vivo
- (2014) Leon M. Tai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
- (2014) Bruno Dubois et al. LANCET NEUROLOGY
- Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
- (2014) David Cook et al. NATURE REVIEWS DRUG DISCOVERY
- ATP-binding cassette transporter A1: From metabolism to neurodegeneration
- (2014) Radosveta Koldamova et al. NEUROBIOLOGY OF DISEASE
- Contribution of Alzheimer disease to mortality in the United States
- (2014) B. D. James et al. NEUROLOGY
- Alzheimer’s disease drug-development pipeline: few candidates, frequent failures
- (2014) Jeffrey L Cummings et al. Alzheimers Research & Therapy
- A Review: Treatment of Alzheimers Disease Discovered in Repurposed Agents
- (2013) Brian S. Appleby et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Monetary Costs of Dementia in the United States
- (2013) Michael D. Hurd et al. NEW ENGLAND JOURNAL OF MEDICINE
- Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"
- (2013) N. F. Fitz et al. SCIENCE
- Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"
- (2013) I. Tesseur et al. SCIENCE
- Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"
- (2013) K. Veeraraghavalu et al. SCIENCE
- Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"
- (2013) A. R. Price et al. SCIENCE
- APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease
- (2012) Katherine L. Youmans et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Ethics of Early Evidence — Preparing for a Possible Breakthrough in Alzheimer's Disease
- (2012) Justin Lowenthal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Preclinical Success against Alzheimer's Disease with an Old Drug
- (2012) Frank M. LaFerla NEW ENGLAND JOURNAL OF MEDICINE
- Old Drug, New Hope for Alzheimer's Disease
- (2012) W. J. Strittmatter SCIENCE
- ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models
- (2012) P. E. Cramer et al. SCIENCE
- Biomarkers in Alzheimer's disease drug development
- (2011) Jeffrey L. Cummings Alzheimers & Dementia
- Use of Florbetapir-PET for Imaging β-Amyloid Pathology
- (2011) Christopher M. Clark JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Aβ-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease
- (2010) Yadong Huang TRENDS IN MOLECULAR MEDICINE
- Bexarotene Induces Dyslipidemia by Increased Very Low-Density Lipoprotein Production and Cholesteryl Ester Transfer Protein-Mediated Reduction of High-Density Lipoprotein
- (2009) Jitske de Vries-van der Weij et al. ENDOCRINOLOGY
- Apolipoprotein E genotyping method by Real Time PCR, a fast and cost-effective alternative to the TaqMan® and FRET assays
- (2009) Olga Calero et al. JOURNAL OF NEUROSCIENCE METHODS
- Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
- (2009) A. Drzezga et al. NEUROLOGY
- Optimizing phase II of drug development for disease-modifying compounds
- (2008) Jeffrey L. Cummings Alzheimers & Dementia
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