Modulation of Receptor Tyrosine Kinase Activity through Alternative Splicing of Ligands and Receptors in the VEGF-A/VEGFR Axis
出版年份 2019 全文链接
标题
Modulation of Receptor Tyrosine Kinase Activity through Alternative Splicing of Ligands and Receptors in the VEGF-A/VEGFR Axis
作者
关键词
-
出版物
Cells
Volume 8, Issue 4, Pages 288
出版商
MDPI AG
发表日期
2019-03-29
DOI
10.3390/cells8040288
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The natural drug DIAVIT is protective in a type II mouse model of diabetic nephropathy
- (2019) Megan Stevens et al. PLoS One
- Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2
- (2018) Chloe Peach et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Positive and Negative Regulation of Angiogenesis by Soluble Vascular Endothelial Growth Factor Receptor-1
- (2018) Cristina Failla et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Modulation of VEGF-A Alternative Splicing as a Novel Treatment in Chronic Kidney Disease
- (2018) et al. Genes
- VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a β1 integrin/VEGFR autocrine loop
- (2018) Asma Boudria et al. ONCOGENE
- Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy
- (2017) Cherine Abou-Fayçal et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Serum Concentrations of Angiopoietin-2 and Soluble fms-Like Tyrosine Kinase 1 (sFlt-1) Are Associated with Coagulopathy among Patients with Acute Pancreatitis
- (2017) Paulina Dumnicka et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- VEGF-A165 b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney
- (2017) Megan Stevens et al. JOURNAL OF PHYSIOLOGY-LONDON
- The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer
- (2017) Robert M. Gemmill et al. Science Signaling
- VEGF-A121a binding to Neuropilins – A concept revisited
- (2017) Sarvenaz Sarabipour et al. Cell Adhesion & Migration
- The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer
- (2017) Robert M. Gemmill et al. Science Signaling
- VEGF 165 b Modulates Endothelial VEGFR1–STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial DiseaseNovelty and Significance
- (2016) Vijay Chaitanya Ganta et al. CIRCULATION RESEARCH
- Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation
- (2016) Takayuki Ikeda et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- VEGFR-2 conformational switch in response to ligand binding
- (2016) Sarvenaz Sarabipour et al. eLife
- VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
- (2016) Gareth W. Fearnley et al. Biology Open
- The Reduction of Serum Soluble Flt-1 in Patients With Neovascular Age-Related Macular Degeneration
- (2015) Hironori Uehara et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Soluble Flt-1 links microvascular disease with heart failure in CKD
- (2015) Giovana S. Di Marco et al. BASIC RESEARCH IN CARDIOLOGY
- Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients
- (2015) Sara M. Tolaney et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration
- (2015) G. W. Fearnley et al. Biology Open
- Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax
- (2014) Sandeepa M. Eswarappa et al. CELL
- PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells
- (2014) Anthony A. Lanahan et al. CIRCULATION
- Antiangiogenic Actions of Vascular Endothelial Growth Factor-A 165 b, an Inhibitory Isoform of Vascular Endothelial Growth Factor-A, in Human Obesity
- (2014) Doan T.M. Ngo et al. CIRCULATION
- Functional and structural characterization of the kinase insert and the carboxy terminal domain in VEGF receptor 2 activation
- (2014) Sandro Manni et al. FASEB JOURNAL
- Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy
- (2014) S. Oltean et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease
- (2014) Ryosuke Kikuchi et al. NATURE MEDICINE
- Serine–arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer
- (2014) A Mavrou et al. ONCOGENE
- Protein kinase C regulates FLT1 abundance and stimulates its cleavage in vascular endothelial cells with the release of a soluble PlGF/VEGF antagonist
- (2013) Nandita S. Raikwar et al. EXPERIMENTAL CELL RESEARCH
- Hypoxia-Regulated Overexpression of Soluble VEGFR2 Controls Angiogenesis and Inhibits Tumor Growth
- (2013) G. Collet et al. MOLECULAR CANCER THERAPEUTICS
- Soluble FLT1 Binds Lipid Microdomains in Podocytes to Control Cell Morphology and Glomerular Barrier Function
- (2012) Jing Jin et al. CELL
- Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing
- (2011) Takayuki Ikeda et al. BIOCHEMICAL JOURNAL
- Signal transduction by vascular endothelial growth factor receptors
- (2011) Sina Koch et al. BIOCHEMICAL JOURNAL
- WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing
- (2011) Elianna M. Amin et al. CANCER CELL
- VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A
- (2011) Raúl Catena et al. Molecular Cancer
- Delivery of Soluble VEGF Receptor 1 (sFlt1) by Gene Electrotransfer as a New Antiangiogenic Cancer Therapy
- (2011) Julien Verrax et al. MOLECULAR PHARMACEUTICS
- Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1
- (2011) J.-N. Boeckel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plasma Vascular Endothelial Growth Factor Dysregulation in Defining Aggressiveness of Head and Neck Squamous Cell Carcinoma
- (2011) Boonchu Kulapaditharom et al. Journal of Oncology
- Opposing roles for HIF-1 and HIF-2 in the regulation of angiogenesis by mononuclear phagocytes
- (2010) T. D. Eubank et al. BLOOD
- Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
- (2010) A. Fantin et al. BLOOD
- Expression of the soluble vascular endothelial growth factor receptor-1 in cutaneous melanoma: role in tumour progression
- (2010) F. Ruffini et al. BRITISH JOURNAL OF DERMATOLOGY
- Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability
- (2010) Ding Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alternate processing of Flt1 transcripts is directed by conserved cis -elements within an intronic region of FLT1 that reciprocally regulates splicing and polyadenylation
- (2010) Christie P. Thomas et al. NUCLEIC ACIDS RESEARCH
- The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo
- (2010) G Merdzhanova et al. ONCOGENE
- HSPG-Binding Peptide Corresponding to the Exon 6a-Encoded Domain of VEGF Inhibits Tumor Growth by Blocking Angiogenesis in Murine Model
- (2010) Tong-Young Lee et al. PLoS One
- VEGFRs and Notch: a dynamic collaboration in vascular patterning: Figure 1
- (2009) Lars Jakobsson et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Local Guidance of Emerging Vessel Sprouts Requires Soluble Flt-1
- (2009) John C. Chappell et al. DEVELOPMENTAL CELL
- Gadd45a stress signaling regulates sFlt-1 expression in preeclampsia
- (2009) Yali Xiong et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study
- (2009) Christopher G. Willett et al. JOURNAL OF CLINICAL ONCOLOGY
- The Soluble VEGF Receptor sFlt1 Contributes to Endothelial Dysfunction in CKD
- (2009) G. S. D. Marco et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Molecular Diversity of VEGF-A as a Regulator of Its Biological Activity
- (2009) Jeanette Woolard et al. MICROCIRCULATION
- Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth
- (2009) Romulo J C Albuquerque et al. NATURE MEDICINE
- A PROSPECTIVE, OBSERVATIONAL STUDY OF SOLUBLE FLT-1 AND VASCULAR ENDOTHELIAL GROWTH FACTOR IN SEPSIS
- (2009) Nathan I. Shapiro et al. SHOCK
- Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium
- (2008) Xuri Li et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Vascular and epithelial junctions: a barrier for leucocyte migration
- (2008) Sarah Garrido-Urbani et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization
- (2008) H. Kawamura et al. BLOOD
- VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy
- (2008) A H R Varey et al. BRITISH JOURNAL OF CANCER
- Vascular Endothelial Growth Factor (VEGF)-A165b Is a Weak In vitro Agonist for VEGF Receptor-2 Due to Lack of Coreceptor Binding and Deficient Regulation of Kinase Activity
- (2008) H. Kawamura et al. CANCER RESEARCH
- Inducible Overexpression of sFlt-1 in Podocytes Ameliorates Glomerulopathy in Diabetic Mice
- (2008) C.-H. Ku et al. DIABETES
- Recombinant human VEGF165b protein is an effective anti-cancer agent in mice
- (2008) Emma S. Rennel et al. EUROPEAN JOURNAL OF CANCER
- The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching
- (2008) Nicholas C. Kappas et al. JOURNAL OF CELL BIOLOGY
- Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
- (2008) D. G. Nowak et al. JOURNAL OF CELL SCIENCE
- A HIF-1α-dependent autocrine feedback loop promotes survival of serum-deprived prostate cancer cells
- (2008) Rusha Thomas et al. PROSTATE
- Vascular endothelial growth factor regulates Stanniocalcin-1 expression via Neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth Factor-2
- (2007) David I.R. Holmes et al. CELLULAR SIGNALLING
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started