Enantioselective N-Heterocyclic Carbene Catalyzed Annulation Reactions with Imidazolidinones

Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators

(2013) Eunhee Chae et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Practical synthesis of potent sphingosine-1-phosphate lyase inhibitors THI and LX2931

(2013) Haiming Zhang et al.   TETRAHEDRON

cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity

(2013) Xingkuan Chen et al.   Chemical Science

A Continuum of Progress: Applications of N-Hetereocyclic Carbene Catalysis in Total Synthesis

(2012) Javier Izquierdo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective synthesis of optically active cis-β-thio-α-amino acid derivatives through an organocatalytic cascade thio-Michael/ring opening process

(2012) Zhi-Cong Geng et al.   CHEMICAL COMMUNICATIONS

Construction of adjacent spiro-quaternary and tertiary stereocenters through phosphine-catalyzed asymmetric [3+2] annulation of allenoates with alkylidene azlactones

(2012) De Wang et al.   CHEMICAL COMMUNICATIONS

Controlled β-protonation and [4+2] cycloaddition of enals and chalconesvia N-heterocyclic carbene/acid catalysis: toward substrate independent reaction control

(2012) Zhenqian Fu et al.   CHEMICAL COMMUNICATIONS

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

Oxyanion Steering and CH−π Interactions as Key Elements in an N-Heterocyclic Carbene-Catalyzed [4 + 2] Cycloaddition

(2012) Scott E. Allen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Extending NHC-Catalysis: Coupling Aldehydes with Unconventional Reaction Partners

(2011) Akkattu T. Biju et al.   ACCOUNTS OF CHEMICAL RESEARCH

Palladium-Catalyzed Diastereo- and Enantioselective Synthesis of Substituted Cyclopentanes through a Dynamic Kinetic Asymmetric Formal [3+2]-Cycloaddition of Vinyl Cyclopropanes and Alkylidene Azlactones

(2011) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Highly Regio- and Stereoselective Cascade Annulation of Enals and Benzodi(enone)s Catalyzed by N-Heterocyclic Carbenes

(2011) Xinqiang Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Comparison of the Non-Nucleoside Reverse Transcriptase Inhibitor Lersivirine with its Pyrazole and Imidazole Isomers

(2011) Lyn H. Jones et al.   Chemical Biology & Drug Design

Employing homoenolates generated by NHC catalysis in carbon–carbon bond-forming reactions: state of the art

(2011) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS

Asymmetric Trienamine Catalysis for the Construction of Structurally Rigid Cyclic α,α-Disubstituted Amino Acid Derivatives

(2011) Hao Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective One-Pot Synthesis of α-Amino Esters by a Phosphine-Catalyzed [3+2]-Cycloaddition Reaction

(2011) Marianne Steurer et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxazolones in Organocatalysis, New Tricks for an Old Reagent

(2011) Andrea-Nekane R. Alba et al.   Chemistry-An Asian Journal

Design and Synthesis of Novel Arylpiperazine Derivatives Containing the Imidazole Core Targeting 5-HT2AReceptor and 5-HT Transporter

(2011) Hee Jeong Seo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanistic Insights on N-Heterocyclic Carbene-Catalyzed Annulations: The Role of Base-Assisted Proton Transfers

(2011) Pragya Verma et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthetic and Quantum Mechanical Studies into the N-Heterocyclic Carbene Catalyzed (4 + 2) Cycloaddition

(2011) Sarah J. Ryan et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene and Brønsted Acid Cooperative Catalysis: Asymmetric Synthesis oftrans-γ-Lactams

(2011) Xiaodan Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic carbene (NHC) catalyzed annulation of enals and vinyl ketones: a novel synthesis of [2H]-pyranones

(2011) Vijay Nair et al.   TETRAHEDRON LETTERS

The effect of the N-mesityl group in NHC-catalyzed reactions

(2011) Jessada Mahatthananchai et al.   Chemical Science

Enantioselective [4+2] cycloaddition of ketenes and 1-azadienes catalyzed by N-heterocyclic carbenes

(2010) Teng-Yue Jian et al.   CHEMICAL COMMUNICATIONS

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

(2010) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective Synthesis of Indole-Fused Dihydropyranones via Catalytic Cycloaddition of Ketenes and 3-Alkylenyloxindoles

(2010) Hui Lv et al.   JOURNAL OF ORGANIC CHEMISTRY

Cooperative catalysis by carbenes and Lewis acids in a highly stereoselective route to γ-lactams

(2010) Dustin E. A. Raup et al.   Nature Chemistry

Understanding the mechanism of stereoselective synthesis of cyclopentenes via N-heterocyclic carbene catalyzed reactions of enals with enones

(2010) Luis R. Domingo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chiral N-heterocyclic carbene-catalyzed generation of ester enolate equivalents from  , -unsaturated aldehydes for enantioselective Diels-Alder reactions

(2010) J. Kaeobamrung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enantioselective Synthesis of DihydrocoumarinsviaN-Heterocyclic Carbene-Catalyzed Cycloaddition of Ketenes ando-Quinone Methides

(2009) Hui Lv et al.   ADVANCED SYNTHESIS & CATALYSIS

Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders

(2009) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stereoselective syntheses of quaternary substituted α-amino acids using oxazol-5-(4H)-ones

(2009) Robert A. Mosey et al.   TETRAHEDRON-ASYMMETRY

[4+2] Cycloaddition of Ketenes withN-Benzoyldiazenes Catalyzed by N-Heterocyclic Carbenes

(2008) Xue-Liang Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ChiralN-Heterocyclic Carbene-Catalyzed Formal [4+2] Cycloaddition of Ketenes with Enones: Highly Enantioselective Synthesis oftrans- andcis-δ-Lactones

(2008) Yan-Rong Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Optimization of 5-Aryloxyimidazole Non-Nucleoside Reverse Transcriptase Inhibitors

(2008) Lyn H. Jones et al.   ChemMedChem

New derivatives and ring systems of annulated pyrrolobenzo[1,4]diazepines

(2008) Andreas Schmidt et al.   TETRAHEDRON

Design and optimization of imidazole derivatives as potent CXCR3 antagonists

(2007) Xiaohui Du et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Stereoselective synthesis of spirocyclopentanones viaN-heterocyclic carbene-catalyzed reactions of enals and dienones

(2007) Vijay Nair et al.   CHEMICAL COMMUNICATIONS