Cooperative N-heterocyclic carbene (NHC)–Lewis acid-mediated regioselective umpolung formal [3 + 2] annulations of alkynyl aldehydes with isatins

An Odorless, One-Pot Synthesis of Thioesters from Organic Halides, Thiourea and Benzoyl Chlorides in Water

(2013) Guo-ping Lu et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances in Asymmetric Organocatalytic Construction of 3,3′-Spirocyclic Oxindoles

(2013) Liang Hong et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene Catalyzed [4+3] Annulation of Enals ando-Quinone Methides: Highly Enantioselective Synthesis of Benzo-ε-Lactones

(2013) Hui Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Efficient Approach to the Securinega Alkaloids Empowered by Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis

(2013) Adel M. ElSohly et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective N-Heterocyclic Carbene Catalyzed Aza-Benzoin Reaction of Enals with Activated Ketimines

(2013) Li-Hui Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene (NHC)-Catalyzed/Lewis Acid Mediated Conjugate Umpolung of Alkynyl Aldehydes for the Synthesis of Butenolides: A Formal [3+2] Annulation

(2013) Jing Qi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters by Using Cascade Reactions Catalyzed by an N-Heterocyclic Carbene

(2013) Bing Zhou et al.   CHEMISTRY-A EUROPEAN JOURNAL

Total Synthesis of Enantiopure Pyrrhoxanthin: Alternative Methods for the Stereoselective Preparation of 4-Alkylidenebutenolides

(2013) Belén Vaz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Extending the Stetter Reaction with 1,6-Acceptors

(2013) Katherine R. Law et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalysis with N-Heterocyclic Carbenes under Oxidative Conditions

(2013) Suman De Sarkar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure Elucidation and Total Synthesis of Altenuic Acid III and Studies towards the Total Synthesis of Altenuic Acid II

(2013) Gregor Nemecek et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cytotoxic Polyketide Derivatives from the South China Sea Sponge Plakortis simplex

(2013) Jinrong Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Asperterrestide A, a Cytotoxic Cyclic Tetrapeptide from the Marine-Derived Fungus Aspergillus terreus SCSGAF0162

(2013) Fei He et al.   JOURNAL OF NATURAL PRODUCTS

Asymmetric Total Synthesis of Caribenol A via an Intramolecular Diels–Alder Reaction

(2013) Jing-Chun Han et al.   JOURNAL OF ORGANIC CHEMISTRY

A Dual Lewis Base Activation Strategy for Enantioselective Carbene-Catalyzed Annulations

(2013) Javier Izquierdo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Activation of Carbohydrates as Formaldehyde Equivalents for Stetter Reaction with Enones

(2013) Junmin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-heterocyclic carbene-catalyzed reactions of C–C unsaturated bonds

(2013) Xiang-Yu Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-heterocyclic carbene catalyzed annulation of benzofuran-2,3-diones and enals: a concise synthesis of spiro-bis-lactone

(2013) Ze-Dong Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NHC-mediated cross-coupling of sugar-derived cyclic nitrones with enals: general and efficient synthesis of polyhydroxylated pyrrolizidines and indolizidines

(2013) Wen-Yuan Xu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NHC-Catalyzed Reaction of Enals with Hydroxy Chalcones: Diastereoselective Synthesis of Functionalized Coumarins

(2013) Anup Bhunia et al.   ORGANIC LETTERS

Highly Chemo- and Enantioselective Cross-Benzoin Reaction of Aliphatic Aldehydes and α-Ketoesters

(2013) Karen Thai et al.   ORGANIC LETTERS

Construction of Spiro-Fused 2-Oxindole/α-Methylene- γ-Butyrolactone Systems with Extremely High Enantioselectivity via Indium-Catalyzed Amide Allylation of N-Methyl Isatin

(2013) Yusuke Murata et al.   ORGANIC LETTERS

Palladium-Catalyzed sp2 and sp3 C–H Bond Activation and Addition to Isatin toward 3-Hydroxy-2-oxindoles

(2013) Gang-Wei Wang et al.   ORGANIC LETTERS

Convergent Access to Bis-spiroacetals through a Sila-Stetter–Ketalization Cascade

(2013) Jessica Labarre-Lainé et al.   ORGANIC LETTERS

Synthesis of 4-benzyl-3-phenylbutenolide natural products

(2013) Anna N. Parker et al.   TETRAHEDRON LETTERS

N-Heterocyclic Carbene-Catalyzed Enantioselective Intramolecular N-Tethered Aldehyde–Ketone Benzoin Reactions

(2013) Min-Qiang Jia et al.   ACS Catalysis

N-Heterocyclic Carbene-Catalyzed Formal [3+2] Annulation of Alkynyl Aldehydes with Nitrosobenzenes: A Highly Regioselective Umpolung Strategy

(2013) Runfeng Han et al.   ACS Catalysis

Asymmetric Catalysis for the Synthesis of Spirocyclic Compounds

(2013) Annaliese K. Franz et al.   ACS Catalysis

Recent Advances in Diversity Oriented Synthesis through Isatin-based Multicomponent Reactions

(2013) Yunyun Liu et al.   Asian Journal of Organic Chemistry

Construction of Contiguous Tetrasubstituted Carbon Stereocenters by Intramolecular Crossed Benzoin Reactions Catalyzed by N-Heterocyclic Carbene (NHC) Organocatalyst

(2012) Tadashi Ema et al.   ADVANCED SYNTHESIS & CATALYSIS

An N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones

(2012) Julien Dugal-Tessier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Intermolecular Stetter Reactions of Enolizable Aldehydes with Nitrostyrenes: Computational Study Provides Insight into the Success of the Catalyst

(2012) Daniel A. DiRocco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Continuum of Progress: Applications of N-Hetereocyclic Carbene Catalysis in Total Synthesis

(2012) Javier Izquierdo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-catalysed diastereoselective synthesis of multifunctionalised piperidines via cascade reaction of enals with azalactones

(2012) Atul K. Singh et al.   CHEMICAL COMMUNICATIONS

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

Highly Enantioselective Intermolecular Stetter Reaction of Simple Acrylates: Synthesis of α-Chiral γ-Ketoesters

(2012) Nathalie E. Wurz et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene-Catalyzed Homoenolate Additions with N-Aryl Ketimines as Electrophiles: Efficient Synthesis of Spirocyclic γ-Lactam Oxindoles

(2012) Bo Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Atom-economical synthesis of the functionalized spirocyclic oxindole-butenolide via three-component [2 + 2 + 1] cycloaddition strategy

(2012) Jian Li et al.   GREEN CHEMISTRY

Diastereoselective and Enantioselective Desymmetrization of α-Substituted Cyclohexadienones via Intramolecular Stetter Reaction

(2012) Min-Qiang Jia et al.   JOURNAL OF ORGANIC CHEMISTRY

Oxidative γ-Addition of Enals to Trifluoromethyl Ketones: Enantioselectivity Control via Lewis Acid/N-Heterocyclic Carbene Cooperative Catalysis

(2012) Junming Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unprecedented dithiolation of enals via their NHC-catalysed umpolung reaction with organic disulfides

(2012) Santosh Singh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Strategies for the enantioselective synthesis of spirooxindoles

(2012) Nicolas R. Ball-Jones et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient Synthesis of γ-Keto Sulfones by NHC-Catalyzed Intermolecular Stetter Reaction

(2012) Anup Bhunia et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Three-Component Domino Reaction of Alkynyl Aldehydes with Oxindoles

(2012) Ding Du et al.   ORGANIC LETTERS

N-Heterocyclic Carbene-Catalyzed Annulation of α-Cyano-1,4-diketones with Ynals

(2012) Fedor Romanov-Michailidis et al.   ORGANIC LETTERS

A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2′-quinoline] Scaffold

(2012) Feng Shi et al.   ORGANIC LETTERS

Multicatalytic Asymmetric Synthesis of Complex Tetrahydrocarbazoles via a Diels–Alder/Benzoin Reaction Sequence

(2012) Yankai Liu et al.   ORGANIC LETTERS

An efficient strategy for functionalized spirolactones and dispirodihydrofuranyl oxindoles using amines and activated alkynes

(2012) Selvarangam E. Kiruthika et al.   TETRAHEDRON LETTERS

Chiral N-Heterocyclic Carbene-Catalyzed Annulations of Enals and Ynals with Stable Enols: A Highly Enantioselective Coates–Claisen Rearrangement

(2012) Jessada Mahatthananchai et al.   ACS Catalysis

Extending NHC-Catalysis: Coupling Aldehydes with Unconventional Reaction Partners

(2011) Akkattu T. Biju et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Heterocyclic Carbene Catalyzed Intramolecular Hydroacylation of Activated Alkynes: Synthesis of Chromones

(2011) Seenuvasan Vedachalam et al.   ADVANCED SYNTHESIS & CATALYSIS

Lewis Acid Activated Synthesis of Highly Substituted Cyclopentanes by the N-Heterocyclic Carbene Catalyzed Addition of Homoenolate Equivalents to Unsaturated Ketoesters

(2011) Daniel T. Cohen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

α,β-Unsaturated Acyl Azoliums from N-Heterocyclic Carbene Catalyzed Reactions: Observation and Mechanistic Investigation

(2011) Jessada Mahatthananchai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral N-heterocyclic carbene catalyzed annulation of α,β-unsaturated aldehydes with 1,3-dicarbonyls

(2011) Zhi-Qiang Zhu et al.   CHEMICAL COMMUNICATIONS

Syntheses of Spirocyclic Oxindole-Butenolides by Using Three-Component Cycloadditions of Isocyanides, Allenoates, and Isatins

(2011) Jian Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic carbene-catalysed intermolecular Stetter reactions of acetaldehyde

(2011) Sun Min Kim et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Understanding the cooperative NHC/LA catalysis for stereoselective annulation reactions with homoenolates. A DFT study

(2011) Luis R. Domingo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NHC-Catalyzed/Titanium(IV)−Mediated Highly Diastereo- and Enantioselective Dimerization of Enals

(2011) Daniel T. Cohen et al.   ORGANIC LETTERS

Asymmetric benzoin condensation promoted by chiral triazolium precatalyst bearing a pyridine moiety

(2011) Takahiro Soeta et al.   TETRAHEDRON

A convenient synthesis of polysubstituted 2-amino-4,5-dihydrofuran-3-nitriles from benzoins or benzaldehydes

(2011) Ding Du et al.   TETRAHEDRON LETTERS

NHC-catalysed, chemoselective crossed-acyloin reactions

(2011) Christopher A. Rose et al.   Chemical Science

Cooperative Lewis acid/N-heterocyclic carbene catalysis

(2011) Daniel T. Cohen et al.   Chemical Science

N-Heterocyclic Carbene-Catalyzed Reaction of Alkynyl Aldehydes with 1,3-Keto Esters or 1,3-Diketones

(2010) Zhi-Qiang Zhu et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of 3'-aroyl-4'-hydroxyspiro-[indole-3,2'-furan]-2,5'(1H)-diones

(2010) V. L. Gein et al.   Chemistry of Heterocyclic Compounds

Efficient synthesis of functionalized butenolides mediated by vinyltriphenylphosphonium salts in aqueous media

(2010) Mohammad A. Khalilzadeh et al.   CHINESE CHEMICAL LETTERS

CooperativeN-Heterocyclic Carbene/Lewis Acid Catalysis for Highly Stereoselective Annulation Reactions with Homoenolates

(2010) Benoit Cardinal-David et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Enantioselective Claisen Rearrangement Catalyzed by N-Heterocyclic Carbenes

(2010) Juthanat Kaeobamrung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cooperative catalysis by carbenes and Lewis acids in a highly stereoselective route to γ-lactams

(2010) Dustin E. A. Raup et al.   Nature Chemistry

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Recent advances in carbon–carbon bond-forming reactions involving homoenolates generated by NHC catalysis

(2008) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS

Highly Diastereo- and Enantioselective Additions of Homoenolates to Nitrones Catalyzed byN-Heterocyclic Carbenes

(2008) Eric M. Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY