Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass

Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy

(2017) Amelia K. Linnemann et al.   FASEB JOURNAL

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion

(2017) Nadejda Bozadjieva et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR and NLRP3 inflammasome expression deregulation in macrophages of adult rats subjected to neonatal malnutrition and infected with methicillin-resistant Staphylococcus aureus

(2017) Natália Gomes de Morais et al.   NUTRITION

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

(2017) Maroof Hasan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal Low-Protein Diet Modulates Glucose Metabolism and Hepatic MicroRNAs Expression in the Early Life of Offspring †

(2017) Jia Zheng et al.   Nutrients

Effects of prenatal low protein and postnatal high fat diets on visceral adipose tissue macrophage phenotypes and IL-6 expression in Sprague Dawley rat offspring

(2017) Linglin Xie et al.   PLoS One

Maternal Low Protein Isocaloric Diet Suppresses Pancreatic β-Cell Proliferation in Mouse Offspring via miR-15b

(2016) Yutong Su et al.   ENDOCRINOLOGY

S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3

(2016) Fuan Wang et al.   NATURE IMMUNOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Maternal protein restriction during gestation impairs female offspring pancreas development in the rat

(2016) Lizbeth Calzada et al.   NUTRITION RESEARCH

A Common Profile of Disordered Angiogenic Factor Production and the Exacerbation of Inflammation in Early Preeclampsia, Late Preeclampsia, and Intrauterine Growth Restriction

(2016) Sebastian Kwiatkowski et al.   PLoS One

Insulin-positive, Glut2-low cells present within mouse pancreas exhibit lineage plasticity and are enriched within extra-islet endocrine cell clusters

(2016) Christine A. Beamish et al.   Islets

Maternal Protein Restriction Leads to Pancreatic Failure in Offspring: Role of Misexpressed MicroRNA-375

(2014) O. Dumortier et al.   DIABETES

Maternal diet–induced microRNAs and mTOR underlie β cell dysfunction in offspring

(2014) Emilyn U. Alejandro et al.   JOURNAL OF CLINICAL INVESTIGATION

The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis

(2014) James Cantley   MAMMALIAN GENOME

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

(2014) Sarah E Flanagan et al.   NATURE GENETICS

Transcriptional regulation of the stress response by mTOR

(2014) J. Aramburu et al.   Science Signaling

Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus

(2013) Anny H. Xiang et al.   DIABETOLOGIA

Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice

(2013) Aaron R Cox et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Placental hormones and the control of maternal metabolism and fetal growth

(2013) Dorothee Newbern et al.   Current Opinion in Endocrinology Diabetes and Obesity

Developmental programming of neonatal pancreatic β-cells by a maternal low-protein diet in rats involves a switch from proliferation to differentiation

(2012) Adriana Rodríguez-Trejo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of inadequate maternal dietary protein:carbohydrate ratios during pregnancy on offspring immunity in pigs

(2012) Margret Tuchscherer et al.   BMC Veterinary Research

Protein restriction in early life is associated with changes in insulin sensitivity and pancreatic β-cell function during pregnancy

(2012) Letícia Martins Ignácio-Souza et al.   BRITISH JOURNAL OF NUTRITION

Protein Restriction during Early Life in Rats Alters Pancreatic GABAA Receptor Subunit Expression and Glucagon Secretion in Adulthood

(2012) Michelle A. Durst et al.   Canadian Journal of Diabetes

Human  -Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

(2012) R. N. Kulkarni et al.   DIABETES

Functional and Structural Adaptations in the Pancreatic α-Cell and Changes in Glucagon Signaling During Protein Malnutrition

(2012) Laura Marroquí et al.   ENDOCRINOLOGY

Maternal malnutrition programs the endocrine pancreas in progeny

(2011) Brigitte Reusens et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Insulin and Glucagon Regulate Pancreatic α-Cell Proliferation

(2011) Zhuo Liu et al.   PLoS One

Rapamycin Impairs Proliferation of Transplanted Islet β Cells

(2011) Nadja Niclauss et al.   TRANSPLANTATION

Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

(2010) A. E. Butler et al.   DIABETOLOGIA

Lineage tracing and resulting phenotype of haemopoietic-derived cells in the pancreas during beta cell regeneration

(2010) A. Chamson-Reig et al.   DIABETOLOGIA

Role of the TSC1-TSC2 Complex in the Integration of Insulin and Glucose Signaling Involved in Pancreatic β-Cell Proliferation

(2010) Alberto Bartolomé et al.   ENDOCRINOLOGY

The Effects of Low Protein During Gestation on Mouse Pancreatic Development and Beta Cell Regeneration

(2010) Aaron R Cox et al.   PEDIATRIC RESEARCH

Exposure of the Pregnant Rat to Low Protein Diet Causes Impaired Glucose Homeostasis in the Young Adult Offspring by Different Mechanisms in Males and Females

(2009) Astrid Chamson-Reig et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of rapamycin pathway

(2009) Eliane Filiputti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

New Insights into mTOR Signaling: mTORC2 and Beyond

(2009) D. R. Alessi et al.   Science Signaling

Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR

(2008) Ying Cai et al.   BIOCHEMICAL PHARMACOLOGY

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1

(2008) M. Rosner et al.   HUMAN MOLECULAR GENETICS

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Interleukin-6 regulates pancreatic  -cell mass expansion

(2008) H. Ellingsgaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of Tsc2 in pancreatic   cells induces   cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

(2008) L. Rachdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Impairs β-Cell Proliferation In Vivo

(2008) E. Zahr et al.   TRANSPLANTATION PROCEEDINGS

Impaired insulin secretion and decreased expression of the nutritionally responsive ribosomal kinase protein S6K-1 in pancreatic islets from malnourished rats

(2007) Eliane Filiputti et al.   LIFE SCIENCES