Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Dilated cardiomyopathy myosin mutants have reduced force-generating capacity

(2018) Zoltan Ujfalusi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level

(2018) Chao Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

(2018) John A. Rohde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals

(2018) Kyoung Hwan Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level

(2018) Chao Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Incident Atrial Fibrillation Is Associated With MYH7 Sarcomeric Gene Variation in Hypertrophic Cardiomyopathy

(2018) Seung-Pyo Lee et al.   Circulation-Heart Failure

Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers

(2018) Robert L. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke

(2018) Michael S. Woody et al.   Nature Communications

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

(2018) Julien Robert-Paganin et al.   Nature Communications

Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy

(2018) Carolyn Y. Ho et al.   CIRCULATION

A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle

(2017) Raja F. Kawas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle

(2017) Anja M. Swenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

(2017) Thomas Kampourakis et al.   JOURNAL OF PHYSIOLOGY-LONDON

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heart failure drug changes the mechanoenzymology of the cardiac myosin powerstroke

(2017) John A. Rohde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

(2017) Vicente J. Planelles-Herrero et al.   Nature Communications

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

(2017) Lorenzo Alamo et al.   eLife

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

(2017) Masataka Kawana et al.   Science Advances

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

(2017) James W. McNamara et al.   PLoS One

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

(2016) Jennifer Davis et al.   CELL

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

(2016) James A. Spudich et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

(2016) James W. McNamara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial

(2016) John R Teerlink et al.   LANCET

Highly selective inhibition of myosin motors provides the basis of potential therapeutic application

(2016) Serena Sirigu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

(2016) Julian R. Homburger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin

(2016) Arjun S. Adhikari et al.   Cell Reports

Strain echocardiography is related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy

(2016) Trine F. Haland et al.   European Heart Journal-Cardiovascular Imaging

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

(2015) James A. Spudich   BIOCHEMICAL SOCIETY TRANSACTIONS

Omecamtiv Mecarbil Modulates the Kinetic and Motile Properties of Porcine β-Cardiac Myosin

(2015) Yingying Liu et al.   BIOCHEMISTRY

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle

(2015) Thomas Kampourakis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Orientation of Myosin Binding Protein C in the Cardiac Muscle Sarcomere Determined by Domain-Specific Immuno-EM

(2015) Kyounghwan Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

New Perspectives on the Prevalence of Hypertrophic Cardiomyopathy

(2015) Christopher Semsarian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules

(2015) Jongmin Sung et al.   Nature Communications

Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector

(2015) Tural Aksel et al.   Cell Reports

Contractility parameters of human  -cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

(2015) S. Nag et al.   Science Advances

Structural Implications of β-Cardiac Myosin Heavy Chain Mutations in Human Disease

(2014) Melanie Colegrave et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Altered interactions between cardiac myosin binding protein-c and α-cardiac actin variants associated with cardiomyopathies

(2014) Melissa L. Chow et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The Myosin Inhibitor Blebbistatin Stabilizes the Super-Relaxed State in Skeletal Muscle

(2014) Clyde Wilson et al.   BIOPHYSICAL JOURNAL

Prediction of Sarcomere Mutations in Subclinical Hypertrophic Cardiomyopathy

(2014) Gabriella Captur et al.   Circulation-Cardiovascular Imaging

Earning stripes: myosin binding protein-C interactions with actin

(2014) Sabine J. van Dijk et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells

(2014) Thomas Kampourakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease

(2013) Christopher Toepfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction

(2013) Willem J. De Lange et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications

(2013) J. L. Woodhead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human  -cardiac myosin motor function

(2013) R. F. Sommese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

(2012) Jeffrey R. Moore et al.   CIRCULATION RESEARCH

Hypertrophic cardiomyopathy

(2012) Barry J Maron et al.   LANCET

Atomic model of the human cardiac muscle myosin filament

(2012) H. A. AL-Khayat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

In the Thick of It

(2011) Samantha P. Harris et al.   CIRCULATION RESEARCH

Novel correlations between the genotype and the phenotype of hypertrophic and dilated cardiomyopathy: results from the German Competence Network Heart Failure

(2011) Stephan Waldmüller et al.   EUROPEAN JOURNAL OF HEART FAILURE

Structure and Interactions of Myosin-binding Protein C Domain C0

(2011) Joyce Ratti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular mechanisms of cardiomyopathy

(2011) Pamela A. Harvey et al.   JOURNAL OF CELL BIOLOGY

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

(2011) John GF Cleland et al.   LANCET

Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

(2011) John R Teerlink et al.   LANCET

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Genetics of hypertrophic cardiomyopathy

(2010) Tetsuo Konno et al.   CURRENT OPINION IN CARDIOLOGY

Malignant and benign mutations in familial cardiomyopathies: Insights into mutations linked to complex cardiovascular phenotypes

(2010) Qian Xu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of Novel Protein Kinase A Phosphorylation Sites in the M-domain of Human and Murine Cardiac Myosin Binding Protein-C Using Mass Spectrometry Analysis

(2010) Weitao Jia et al.   JOURNAL OF PROTEOME RESEARCH

Myocardial Fibrosis as an Early Manifestation of Hypertrophic Cardiomyopathy

(2010) Carolyn Y. Ho et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiomyopathy: A Systematic Review of Disease-Causing Mutations in Myosin Heavy Chain 7 and Their Phenotypic Manifestations

(2009) R. Walsh et al.   CARDIOLOGY

Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy

(2009) Sabine J. van Dijk et al.   CIRCULATION

Evidence From Human Myectomy Samples That MYBPC3 Mutations Cause Hypertrophic Cardiomyopathy Through Haploinsufficiency

(2009) Steven Marston et al.   CIRCULATION RESEARCH

Echocardiographic Strain Imaging to Assess Early and Late Consequences of Sarcomere Mutations in Hypertrophic Cardiomyopathy

(2009) Carolyn Y. Ho et al.   Circulation-Cardiovascular Genetics

The Myosin-binding Protein C Motif Binds to F-actin in a Phosphorylation-sensitive Manner

(2009) Justin F. Shaffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blebbistatin Stabilizes the Helical Order of Myosin Filaments by Promoting the Switch 2 Closed State

(2008) Fa-Qing Zhao et al.   BIOPHYSICAL JOURNAL

Myosin Binding Protein C Positioned to Play a Key Role in Regulation of Muscle Contraction: Structure and Interactions of Domain C1

(2008) Abdessamad Ababou et al.   JOURNAL OF MOLECULAR BIOLOGY

Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity

(2008) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Bioinformatics Assessment of β-Myosin Mutations Reveals Myosin's High Sensitivity to Mutations

(2008) Massimo Buvoli et al.   TRENDS IN CARDIOVASCULAR MEDICINE