Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

X-ray diffraction analysis of the effects of myosin regulatory light chain phosphorylation and butanedione monoxime on skinned skeletal muscle fibers

(2016) Maki Yamaguchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples

(2016) Roddy Walsh et al.   GENETICS IN MEDICINE

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

(2016) James A. Spudich et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

(2016) James W. McNamara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis

(2016) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Revisiting Frank-Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (ktr) in a length-dependent fashion

(2016) Christopher N. Toepfer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle

(2016) Leonardo Nogara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

(2016) Julian R. Homburger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 A resolution

(2016) Z. Hu et al.   Science Advances

Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle

(2016) Leonardo Nogara et al.   PLoS One

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

(2015) James A. Spudich   BIOCHEMICAL SOCIETY TRANSACTIONS

The Conformation of Myosin Heads in Relaxed Skeletal Muscle: Implications for Myosin-Based Regulation

(2015) Luca Fusi et al.   BIOPHYSICAL JOURNAL

How Actin Initiates the Motor Activity of Myosin

(2015) Paola Llinas et al.   DEVELOPMENTAL CELL

Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity

(2015) Ahmed A. Alfares et al.   GENETICS IN MEDICINE

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle

(2015) Thomas Kampourakis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Orientation of Myosin Binding Protein C in the Cardiac Muscle Sarcomere Determined by Domain-Specific Immuno-EM

(2015) Kyounghwan Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

Sequential myosin phosphorylation activates tarantula thick filament via a disorder–order transition

(2015) L. Michel Espinoza-Fonseca et al.   Molecular BioSystems

Tarantula myosin free head regulatory light chain phosphorylation stiffens N-terminal extension, releasing it and blocking its docking back

(2015) Lorenzo Alamo et al.   Molecular BioSystems

Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments

(2015) Marco Linari et al.   NATURE

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice

(2015) Chen-Ching Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Implications of β-Cardiac Myosin Heavy Chain Mutations in Human Disease

(2014) Melanie Colegrave et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

(2014) James A. Spudich   BIOPHYSICAL JOURNAL

The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing

(2014) Trevor J. Pugh et al.   GENETICS IN MEDICINE

Different Head Environments in Tarantula Thick Filaments Support a Cooperative Activation Process

(2013) Guidenn Sulbarán et al.   BIOPHYSICAL JOURNAL

Accurate SAXS Profile Computation and its Assessment by Contrast Variation Experiments

(2013) Dina Schneidman-Duhovny et al.   BIOPHYSICAL JOURNAL

X-Ray Solution Scattering of Squid Heavy Meromyosin: Strengthening the Evidence for an Ancient Compact off State

(2013) Richard E. Gillilan et al.   PLoS One

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human  -cardiac myosin motor function

(2013) R. F. Sommese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

(2012) Jeffrey R. Moore et al.   CIRCULATION RESEARCH

Subtle Abnormalities in Contractile Function Are an Early Manifestation of Sarcomere Mutations in Dilated Cardiomyopathy

(2012) Neal K. Lakdawala et al.   Circulation-Cardiovascular Genetics

Atomic model of the human cardiac muscle myosin filament

(2012) H. A. AL-Khayat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

In the Thick of It

(2011) Samantha P. Harris et al.   CIRCULATION RESEARCH

Disease Pathways and Novel Therapeutic Targets in Hypertrophic Cardiomyopathy

(2011) Houman Ashrafian et al.   CIRCULATION RESEARCH

A Molecular Model of Phosphorylation-Based Activation and Potentiation of Tarantula Muscle Thick Filaments

(2011) Reicy Brito et al.   JOURNAL OF MOLECULAR BIOLOGY

Slow Myosin ATP Turnover in the Super-Relaxed State in Tarantula Muscle

(2011) Nariman Naber et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle

(2011) P. K. Luther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies?

(2011) Steven B. Marston   Journal of Cardiovascular Translational Research

Genetics of hypertrophic cardiomyopathy

(2010) Tetsuo Konno et al.   CURRENT OPINION IN CARDIOLOGY

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms

(2009) Jingui Zhu et al.   BMC GENOMICS

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics

(2008) Michael J. Greenberg et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity

(2008) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Head–Head and Head–Tail Interaction: A General Mechanism for Switching Off Myosin II Activity in Cells

(2008) Hyun Suk Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA