The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

(2017) Masataka Kawana et al.   Science Advances

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin

(2016) James A. Spudich et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Conserved Intramolecular Interactions Maintain Myosin Interacting-Heads Motifs Explaining Tarantula Muscle Super-Relaxed State Structural Basis

(2016) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution

(2016) Julian von der Ecken et al.   NATURE

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation

(2016) Julian R. Homburger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin

(2016) Arjun S. Adhikari et al.   Cell Reports

Structure of myosin filaments from relaxed Lethocerus flight muscle by cryo-EM at 6 A resolution

(2016) Z. Hu et al.   Science Advances

Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle

(2016) Leonardo Nogara et al.   PLoS One

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

(2015) James A. Spudich   BIOCHEMICAL SOCIETY TRANSACTIONS

Single-Particle Cryo-EM at Crystallographic Resolution

(2015) Yifan Cheng   CELL

Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization

(2015) Yirui Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle

(2015) Thomas Kampourakis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity

(2015) Eva Nogales et al.   MOLECULAR CELL

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

How cryo-EM is revolutionizing structural biology

(2015) Xiao-chen Bai et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity

(2015) Donald A. Winkelmann et al.   Nature Communications

Contractility parameters of human  -cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function

(2015) S. Nag et al.   Science Advances

Structural Implications of β-Cardiac Myosin Heavy Chain Mutations in Human Disease

(2014) Melanie Colegrave et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

(2014) James A. Spudich   BIOPHYSICAL JOURNAL

Zebrafish Cardiac Muscle Thick Filaments: Isolation Technique and Three-Dimensional Structure

(2014) Maryví González-Solá et al.   BIOPHYSICAL JOURNAL

Sarcomere Mutation-Specific Expression Patterns in Human Hypertrophic Cardiomyopathy

(2014) A. S. Helms et al.   Circulation-Cardiovascular Genetics

BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing

(2014) Rui Guo et al.   MOLECULAR CELL

Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease

(2013) Christopher Toepfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications

(2013) J. L. Woodhead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human  -cardiac myosin motor function

(2013) R. F. Sommese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Rigor Actin-Tropomyosin-Myosin Complex

(2012) Elmar Behrmann et al.   CELL

Understanding Cardiomyopathy Phenotypes Based on the Functional Impact of Mutations in the Myosin Motor

(2012) Jeffrey R. Moore et al.   CIRCULATION RESEARCH

Phosphatidylinositol 4,5-Bisphosphate Increases Ca2+Affinity of Synaptotagmin-1 by 40-fold

(2012) Geert van den Bogaart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The myosin interacting-heads motif is present in the relaxed thick filament of the striated muscle of scorpion

(2012) Antonio Pinto et al.   JOURNAL OF STRUCTURAL BIOLOGY

Hypertrophic cardiomyopathy

(2012) Barry J Maron et al.   LANCET

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

(2012) Susanne A.I. Seidel et al.   METHODS

Update on activities at the Universal Protein Resource (UniProt) in 2013

(2012)   NUCLEIC ACIDS RESEARCH

Atomic model of the human cardiac muscle myosin filament

(2012) H. A. AL-Khayat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational identification of self-inhibitory peptides from envelope proteins

(2012) Yongtao Xu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The significance of regulatory light chain phosphorylation in cardiac physiology

(2011) Sarah B. Scruggs et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

In the Thick of It

(2011) Samantha P. Harris et al.   CIRCULATION RESEARCH

Structure and Interactions of Myosin-binding Protein C Domain C0

(2011) Joyce Ratti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular mechanisms of cardiomyopathy

(2011) Pamela A. Harvey et al.   JOURNAL OF CELL BIOLOGY

Role of the Tail in the Regulated State of Myosin 2

(2011) Hyun Suk Jung et al.   JOURNAL OF MOLECULAR BIOLOGY

A Molecular Model of Phosphorylation-Based Activation and Potentiation of Tarantula Muscle Thick Filaments

(2011) Reicy Brito et al.   JOURNAL OF MOLECULAR BIOLOGY

Slow Myosin ATP Turnover in the Super-Relaxed State in Tarantula Muscle

(2011) Nariman Naber et al.   JOURNAL OF MOLECULAR BIOLOGY

Myosin Binding Protein C Interaction with Actin

(2010) Inna N. Rybakova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Novel Protein Kinase A Phosphorylation Sites in the M-domain of Human and Murine Cardiac Myosin Binding Protein-C Using Mass Spectrometry Analysis

(2010) Weitao Jia et al.   JOURNAL OF PROTEOME RESEARCH

Cardiomyopathy: A Systematic Review of Disease-Causing Mutations in Myosin Heavy Chain 7 and Their Phenotypic Manifestations

(2009) R. Walsh et al.   CARDIOLOGY

Evidence From Human Myectomy Samples That MYBPC3 Mutations Cause Hypertrophic Cardiomyopathy Through Haploinsufficiency

(2009) Steven Marston et al.   CIRCULATION RESEARCH

Prevalence of Sarcomere Protein Gene Mutations in Preadolescent Children With Hypertrophic Cardiomyopathy

(2009) Juan Pablo Kaski et al.   Circulation-Cardiovascular Genetics

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity

(2008) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Head–Head Interaction Characterizes the Relaxed State of Limulus Muscle Myosin Filaments

(2008) Fa-Qing Zhao et al.   JOURNAL OF MOLECULAR BIOLOGY

Head–Head and Head–Tail Interaction: A General Mechanism for Switching Off Myosin II Activity in Cells

(2008) Hyun Suk Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Shared Genetic Causes of Cardiac Hypertrophy in Children and Adults

(2008) Hiroyuki Morita et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution

(2008) H. S. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of protein function leaps by directed domain interface evolution

(2008) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatics Assessment of β-Myosin Mutations Reveals Myosin's High Sensitivity to Mutations

(2008) Massimo Buvoli et al.   TRENDS IN CARDIOVASCULAR MEDICINE