Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice

Activation of mTORC1 in B Lymphocytes Promotes Osteoclast Formation via Regulation of β-Catenin and RANKL/OPG

(2016) Song Xu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation

(2016) Bo Yan et al.   Nature Communications

Everolimus restrains the paracrine pro-osteoclast activity of breast cancer cells

(2015) Valeria Simone et al.   BMC CANCER

Lysosomal pH Plays a Key Role in Regulation of mTOR Activity in Osteoclasts

(2015) Yingwei Hu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts

(2015) Matthew B. Greenblatt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brief Report: The Differential Roles of mTORC1 and mTORC2 in Mesenchymal Stem Cell Differentiation

(2015) Sally K. Martin et al.   STEM CELLS

mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway

(2015) Bin Huang et al.   PLoS Genetics

mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts

(2015) Jianquan Chen et al.   PLoS One

The effect of enoxacin on osteoclastogenesis and reduction of titanium particle-induced osteolysis via suppression of JNK signaling pathway

(2014) Xuqiang Liu et al.   BIOMATERIALS

mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis

(2014) Jianquan Chen et al.   DEVELOPMENT

mTOR inhibition rescues osteopenia in mice with systemic sclerosis

(2014) Chider Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone effects of mammalian target of rapamycin (mTOR) inhibition with everolimus

(2013) Peyman Hadji et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts

(2013) Brendan F Boyce   JOURNAL OF BONE AND MINERAL RESEARCH

Rapamycin inhibits BMP-7-induced osteogenic and lipogenic marker expressions in fetal rat calvarial cells

(2013) Lee-Chuan C. Yeh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2

(2013) Weiguo Zou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effect of Everolimus on Bone Marker Levels and Progressive Disease in Bone in BOLERO-2

(2013) M. Gnant et al.   JNCI-Journal of the National Cancer Institute

S6K1 in the Central Nervous System Regulates Energy Expenditure via MC4R/CRH Pathways in Response to Deprivation of an Essential Amino Acid

(2012) T. Xia et al.   DIABETES

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

Long-term outcome of cryopreserved bone-derived osteoblasts for bone regeneration in vivo

(2011) Shaoyi Wang et al.   BIOMATERIALS

Repairing critical-sized calvarial defects with BMSCs modified by a constitutively active form of hypoxia-inducible factor-1α and a phosphate cement scaffold

(2011) Duohong Zou et al.   BIOMATERIALS

Cellular and Molecular Mechanisms of Bone Remodeling

(2010) Liza J. Raggatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

(2010) A. Michael Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapamycin Promotes the Osteoblastic Differentiation of Human Embryonic Stem Cells by Blocking the mTOR Pathway and Stimulating the BMP/Smad Pathway

(2009) Kyu-Won Lee et al.   STEM CELLS AND DEVELOPMENT

Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells

(2007) Ujjal K. Singha et al.   JOURNAL OF CELLULAR BIOCHEMISTRY