标题
Molecular Mechanisms of Hypothalamic Insulin Resistance
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 6, Pages 1317
出版商
MDPI AG
发表日期
2019-03-18
DOI
10.3390/ijms20061317
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Insulin transport into the brain
- (2018) Sarah M. Gray et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain
- (2018) Maria Hersom et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity and diabetes: Translational significance
- (2018) Md Habibur Rahman et al. BIOCHEMICAL PHARMACOLOGY
- TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding
- (2018) Garron T. Dodd et al. DIABETES
- Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats
- (2018) Mélanie Campana et al. Molecular Metabolism
- Genetic identification of leptin neural circuits in energy and glucose homeostases
- (2018) Jie Xu et al. NATURE
- Insulin regulates POMC neuronal plasticity to control glucose metabolism
- (2018) Garron T Dodd et al. eLife
- PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions
- (2018) Karina Sánchez-Alegría et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Hypothalamic PDE3B deficiency alters body weight and glucose homeostasis in mouse
- (2018) Maitrayee Sahu et al. JOURNAL OF ENDOCRINOLOGY
- Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation
- (2018) Chan Hee Lee et al. Cell Reports
- Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice
- (2017) Gota Sakai et al. ENDOCRINOLOGY
- Region-Specific Suppression of Hypothalamic Responses to Insulin To Adapt to Elevated Maternal Insulin Secretion During Pregnancy
- (2017) Sharon R Ladyman et al. ENDOCRINOLOGY
- Hypothalamic inflammation in obesity and metabolic disease
- (2017) Alexander Jais et al. JOURNAL OF CLINICAL INVESTIGATION
- Insulin action in the brain: Roles in energy and glucose homeostasis
- (2017) G. T. Dodd et al. JOURNAL OF NEUROENDOCRINOLOGY
- Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice
- (2017) Masahiro Konishi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Central insulin modulates food valuation via mesolimbic pathways
- (2017) Lena J. Tiedemann et al. Nature Communications
- Dietary sugars, not lipids, drive hypothalamic inflammation
- (2017) Yuanqing Gao et al. Molecular Metabolism
- Insulin controls food intake and energy balance via NPY neurons
- (2017) Kim Loh et al. Molecular Metabolism
- Hypothalamic roles of mTOR complex I: integration of nutrient and hormone signals to regulate energy homeostasis
- (2016) Fang Hu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Pathways for insulin access to the brain: the role of the microvascular endothelial cell
- (2016) Rick I. Meijer et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- DEPTOR in POMC neurons affects liver metabolism but is dispensable for the regulation of energy balance
- (2016) Alexandre Caron et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue
- (2016) Sophie M. Steculorum et al. CELL
- Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability
- (2016) Cristina García-Cáceres et al. CELL
- Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I
- (2016) Ana M. Fernandez et al. DIABETES
- Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation
- (2016) Caroline André et al. DIABETES
- Glial cells and energy balance
- (2016) Pilar Argente-Arizón et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Hypothalamic Phosphodiesterase 3B Pathway Mediates Anorectic and Body Weight-Reducing Effects of Insulin in Male Mice
- (2016) Maitrayee Sahu et al. NEUROENDOCRINOLOGY
- Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor
- (2016) Kumi Kimura et al. Cell Reports
- Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity
- (2016) Alexandre Caron et al. Molecular Metabolism
- CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5
- (2016) Szu-Yi Chou et al. Scientific Reports
- Is Brain Insulin Action Relevant to the Control of Plasma Glucose in Humans?: Figure 1
- (2015) Dale S. Edgerton et al. DIABETES
- Selective Insulin Resistance in Homeostatic and Cognitive Control Brain Areas in Overweight and Obese Adults
- (2015) Stephanie Kullmann et al. DIABETES CARE
- Is Insulin Action in the Brain Relevant in Regulating Blood Glucose in Humans?
- (2015) Satya Dash et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice
- (2015) Eugenia Mc Allister et al. PHYSIOLOGY & BEHAVIOR
- Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling
- (2015) Zhong-Yin Zhang et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice
- (2015) Mark A. Smith et al. Cell Reports
- Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake
- (2015) Anne Drougard et al. Frontiers in Neuroscience
- Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice
- (2015) Laura B. Buckman et al. Molecular Metabolism
- Mediobasal hypothalamic PTEN modulates hepatic insulin resistance independently of food intake in rats
- (2014) Takashi Sumita et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance
- (2014) Sarah M. Turpin et al. Cell Metabolism
- Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain
- (2014) Eglantine Balland et al. Cell Metabolism
- Hypothalamic Tanycytes: Gatekeepers to Metabolic Control
- (2014) Yuanqing Gao et al. Cell Metabolism
- Preserved Energy Balance in Mice Lacking FoxO1 in Neurons of Nkx2.1 Lineage Reveals Functional Heterogeneity of FoxO1 Signaling Within the Hypothalamus
- (2014) Garrett Heinrich et al. DIABETES
- Central Nervous Insulin Administration Does Not Potentiate the Acute Glucoregulatory Impact of Concurrent Mild Hyperinsulinemia
- (2014) Volker Ott et al. DIABETES
- Insulin Action in Brain Regulates Systemic Metabolism and Brain Function
- (2014) A. Kleinridders et al. DIABETES
- Hypothalamic Gliosis Associated With High-Fat Diet Feeding Is Reversible in Mice: A Combined Immunohistochemical and Magnetic Resonance Imaging Study
- (2014) Kathryn E. Berkseth et al. ENDOCRINOLOGY
- GABAergic Neurogliaform Cells Represent Local Sources of Insulin in the Cerebral Cortex
- (2014) G. Molnar et al. JOURNAL OF NEUROSCIENCE
- Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance
- (2014) Eva Tsaousidou et al. Cell Reports
- Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function
- (2014) Martin Valdearcos et al. Cell Reports
- Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance
- (2014) Cristina Contreras et al. Cell Reports
- Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity
- (2014) João A.B. Pedroso et al. Molecular Metabolism
- Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis
- (2014) Heidi E. Kocalis et al. Molecular Metabolism
- Evidence for altered transport of insulin across the blood–brain barrier in insulin-resistant humans
- (2013) Martin Heni et al. ACTA DIABETOLOGICA
- Central Activating Transcription Factor 4 (ATF4) Regulates Hepatic Insulin Resistance in Mice via S6K1 Signaling and the Vagus Nerve
- (2013) Q. Zhang et al. DIABETES
- Hormones and diet, but not body weight, control hypothalamic microglial activity
- (2013) Yuanqing Gao et al. GLIA
- Long-term Drug Treatment for Obesity
- (2013) Susan Z. Yanovski et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Evidence for Central Regulation of Glucose Metabolism
- (2013) Michelle Carey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids
- (2013) Gwenaël Labouèbe et al. NATURE NEUROSCIENCE
- FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake
- (2012) Hongxia Ren et al. CELL
- Evidence against a Physiologic Role for Acute Changes in CNS Insulin Action in the Rapid Regulation of Hepatic Glucose Production
- (2012) Christopher J. Ramnanan et al. Cell Metabolism
- In VivoChanges in Central and Peripheral Insulin Sensitivity in a Large Animal Model of Obesity
- (2012) Clare L. Adam et al. ENDOCRINOLOGY
- Phosphatidylinositol 3-kinase is an Upstream Regulator of the Phosphodiesterase 3B Pathway of Leptin Signalling that may not Involve Activation of Akt in the Rat Hypothalamus
- (2012) A. Sahu et al. JOURNAL OF NEUROENDOCRINOLOGY
- High calorie diet triggers hypothalamic angiopathy
- (2012) Chun-Xia Yi et al. Molecular Metabolism
- The hypothalamus bridges the gap between physiology and biochemistry in high-fat diet-induced hepatic insulin resistance
- (2011) Hiraku Ono CELL CYCLE
- Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis
- (2011) Thomas Scherer et al. Cell Metabolism
- Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance
- (2011) Kim Loh et al. Cell Metabolism
- Obesity is associated with hypothalamic injury in rodents and humans
- (2011) Joshua P. Thaler et al. JOURNAL OF CLINICAL INVESTIGATION
- Consumption of a high-fat diet induces central insulin resistance independent of adiposity
- (2011) Deborah J. Clegg et al. PHYSIOLOGY & BEHAVIOR
- Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids
- (2010) Sun Ju Choi et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice
- (2010) Ryoichi Banno et al. JOURNAL OF CLINICAL INVESTIGATION
- The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid
- (2010) Esteban M. Rodríguez et al. PEPTIDES
- MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity
- (2009) André Kleinridders et al. Cell Metabolism
- Hypothalamic Reactive Oxygen Species Are Required for Insulin-Induced Food Intake Inhibition: An NADPH Oxidase-Dependent Mechanism
- (2009) T. Jaillard et al. DIABETES
- Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity
- (2009) M. Milanski et al. JOURNAL OF NEUROSCIENCE
- The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
- (2009) Leona Plum et al. NATURE MEDICINE
- Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin
- (2009) Jong Chul Won et al. Obesity
- Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
- (2008) Kelly A. Posey et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
- (2008) Xiaoqing Zhang et al. CELL
- Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis
- (2008) Clémence Blouet et al. Cell Metabolism
- Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats
- (2008) Paty Karoll Picardi et al. ENDOCRINOLOGY
- Starvation and Triglycerides Reverse the Obesity-Induced Impairment of Insulin Transport at the Blood-Brain Barrier
- (2008) Akihiko Urayama et al. ENDOCRINOLOGY
- Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo
- (2008) Janice M. Zabolotny et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential Sensitivity of Men and Women to Anorexigenic and Memory-Improving Effects of Intranasal Insulin
- (2008) Christian Benedict et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
- (2008) Hiraku Ono et al. JOURNAL OF CLINICAL INVESTIGATION
- Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion
- (2007) Esther van de Wall et al. ENDOCRINOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now