PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions

Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4

(2018) J. Pearson-Leary et al.   BEHAVIOURAL BRAIN RESEARCH

Histone deacetylase 1 promotes glioblastoma cell proliferation and invasion via activation of PI3K/AKT and MEK/ERK signaling pathways

(2018) Shun Li et al.   BRAIN RESEARCH

The effect of P85 on neuronal proliferation and differentiation during development of mouse cerebral cortex

(2018) Xinran Cheng et al.   DEVELOPMENTAL BIOLOGY

EZH2 Methyltransferase Activity Controls Pten Expression and mTOR Signaling During Fear Memory Reconsolidation

(2018) Timothy J. Jarome et al.   JOURNAL OF NEUROSCIENCE

PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

(2018) Paul M Daniel et al.   NEURO-ONCOLOGY

A postsynaptic PI3K-cII dependent signaling controller for presynaptic homeostatic plasticity

(2018) Anna G Hauswirth et al.   eLife

The Role of Insulin/IGF-1/PI3K/Akt/GSK3β Signaling in Parkinson's Disease Dementia

(2018) Liying Yang et al.   Frontiers in Neuroscience

Akt3 deletion in mice impairs spatial cognition and hippocampal CA1 long long-term potentiation through downregulation of mTOR

(2018) Tingting Zhang et al.   Acta Physiologica

Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway

(2018) Guiling Chen et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Endosomal sorting and trafficking, the retromer complex and neurodegeneration

(2018) Alana N. Vagnozzi et al.   MOLECULAR PSYCHIATRY

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

(2018) Claudia Brandt et al.   NEUROPHARMACOLOGY

Suppression of Lipopolysaccharide-Induced Neuroinflammation by Morin via MAPK, PI3K/Akt, and PKA/HO-1 Signaling Pathway Modulation

(2017) Ji-Sun Jung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

PI3K class II α regulates δ-opioid receptor export from the trans-Golgi network

(2017) Daniel J. Shiwarski et al.   MOLECULAR BIOLOGY OF THE CELL

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons

(2017) Cristian Gerónimo-Olvera et al.   Cell Death & Disease

The Membrane Glycoprotein M6a Endocytic/Recycling Pathway Involves Clathrin-Mediated Endocytosis and Affects Neuronal Synapses

(2017) Micaela D. Garcia et al.   Frontiers in Molecular Neuroscience

PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

(2017) Xi Zhang et al.   Stem Cell Reports

Towards Targeting PI3K-Dependent Regulation of Gene Expression in Brain Cancer

(2017) Theo Mantamadiotis   Cancers

Nonsteroidal anti-inflammatory drugs modulate cellular glycosaminoglycan synthesis by affecting EGFR and PI3K signaling pathways

(2017) Paweł Mozolewski et al.   Scientific Reports

Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice

(2016) Christian Griñán-Ferré et al.   Aging-US

Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis

(2016) Dah Ihm Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metabolic reprogramming during neuronal differentiation

(2016) M Agostini et al.   CELL DEATH AND DIFFERENTIATION

Intracellular signaling pathway regulation of myelination and remyelination in the CNS

(2016) Jenna M. Gaesser et al.   EXPERIMENTAL NEUROLOGY

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

(2016) Antonia Cianciulli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury

(2016) Po Wang et al.   Journal of Neuroinflammation

Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease

(2016) Zhe-Min Shi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Acetyl-l-carnitine restores synaptic transmission and enhances the inducibility of stable LTP after oxygen–glucose deprivation

(2016) Kitti Kocsis et al.   NEUROSCIENCE

Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

(2016) Corey T. Watson et al.   Genome Medicine

Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons

(2016) Jong-Woo Sohn et al.   Molecular Metabolism

PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia

(2015) Laura A. Jansen et al.   BRAIN

miR-362-5p inhibits proliferation and migration of neuroblastoma cells by targeting phosphatidylinositol 3-kinase-C2β

(2015) Kai Wu et al.   FEBS LETTERS

Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Akt/mTOR signaling pathway in hippocampal neurons

(2015) Zhaohua Xiao et al.   JOURNAL OF NEUROIMMUNOLOGY

Phosphoinositide 3-Kinase Gamma Contributes to Neuroinflammation in a Rat Model of Surgical Brain Injury

(2015) L. Huang et al.   JOURNAL OF NEUROSCIENCE

Infection, systemic inflammation, and Alzheimer's disease

(2015) Siok Lam Lim et al.   MICROBES AND INFECTION

Cadmium-induced autophagy promotes survival of rat cerebral cortical neurons by activating class III phosphoinositide 3-kinase/beclin-1/B-cell lymphoma 2 signaling pathways

(2015) QI-WEN WANG et al.   Molecular Medicine Reports

Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease

(2015) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain

(2015) Pritika J. Narayan et al.   NEUROBIOLOGY OF DISEASE

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

(2015) Christina Gross et al.   Cell Reports

When astrocytes become harmful: Functional and inflammatory responses that contribute to Alzheimer's disease

(2014) Evangelina Avila-Muñoz et al.   AGEING RESEARCH REVIEWS

Megalencephaly and hemimegalencephaly: Breakthroughs in molecular etiology

(2014) Ghayda M. Mirzaa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

The PI3K Class III Complex Promotes Axon Pruning by Downregulating a Ptc-Derived Signal via Endosome-Lysosomal Degradation

(2014) Noa Issman-Zecharya et al.   DEVELOPMENTAL CELL

Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells

(2014) Márcio Ribeiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Classes of phosphoinositide 3-kinases at a glance

(2014) S. Jean et al.   JOURNAL OF CELL SCIENCE

FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers

(2014) Y Leng et al.   MOLECULAR PSYCHIATRY

The role of TLR4-mediated PTEN/PI3K/AKT/NF-κB signaling pathway in neuroinflammation in hippocampal neurons

(2014) M. Zhao et al.   NEUROSCIENCE

The Anti-Tumor Histone Deacetylase Inhibitor SAHA and the Natural Flavonoid Curcumin Exhibit Synergistic Neuroprotection against Amyloid-Beta Toxicity

(2014) Jia Meng et al.   PLoS One

Targeting Class IA PI3K Isoforms Selectively Impairs Cell Growth, Survival, and Migration in Glioblastoma

(2014) Katrin Höland et al.   PLoS One

Histone Acetyltransferase p300 Mediates Histone Acetylation of PS1 and BACE1 in a Cellular Model of Alzheimer's Disease

(2014) Xi Lu et al.   PLoS One

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

Effects of PI3Kβ overexpression in the hippocampus on synaptic plasticity and spatial learning

(2014) Jun-Hyeok Choi et al.   Molecular Brain

The effect of high fat diet and saturated fatty acids on insulin signaling in the amygdala and hypothalamus of rats

(2013) Hyoungil Oh et al.   BRAIN RESEARCH

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

(2013) York Posor et al.   NATURE

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

(2013) Kelly Devereaux et al.   PLoS One

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

(2013) P Sanphui et al.   Cell Death & Disease

Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer’s disease

(2012) Michael P. Walker et al.   AGE

Regulation and cellular functions of class II phosphoinositide 3-kinases

(2012) Marco Falasca et al.   BIOCHEMICAL JOURNAL

Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K

(2012) Ty Dale Troutman et al.   CELL CYCLE

Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony

(2012) Rodrigo Medeiros et al.   EXPERIMENTAL NEUROLOGY

The PI3K/Akt pathway is required for LPS activation of microglial cells

(2012) Concetta Saponaro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosisviamitochondrial-lysosomal cross-talk

(2012) Christian Seitz et al.   INTERNATIONAL JOURNAL OF CANCER

Leukocyte migration from a fish eye's view

(2012) Qing Deng et al.   JOURNAL OF CELL SCIENCE

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes

(2012) Jean-Baptiste Rivière et al.   NATURE GENETICS

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Epigenetic regulation of BACE1 in Alzheimer’s disease patients and in transgenic mice

(2012) S.C.F. Marques et al.   NEUROSCIENCE

Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent β-Amyloid Generation

(2011) Jing Wu et al.   CELL

Phosphoinositide-3-Kinase Activation Controls Synaptogenesis and Spinogenesis in Hippocampal Neurons

(2011) G. Cuesto et al.   JOURNAL OF NEUROSCIENCE

Neuroprotectin D1 Induces Neuronal Survival and Downregulation of Amyloidogenic Processing in Alzheimer’s Disease Cellular Models

(2011) David T. Stark et al.   MOLECULAR NEUROBIOLOGY

PI3Kγ is required for NMDA receptor–dependent long-term depression and behavioral flexibility

(2011) Jae-Ick Kim et al.   NATURE NEUROSCIENCE

Multiple Functions of Phosphoinositide-3 Kinase Enhancer (PIKE)

(2011) Chi Bun Chan et al.   TheScientificWorldJOURNAL

Dynamic association of p300 with the promoter of the G protein-coupled rat delta opioid receptor gene during NGF-induced neuronal differentiation

(2010) Yulong L. Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NSAID Sulindac and Its Analog Bind RXRα and Inhibit RXRα-Dependent AKT Signaling

(2010) Hu Zhou et al.   CANCER CELL

Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis

(2010) Feifan Zhou et al.   FEBS Journal

MBSJ MCC Young Scientist Award 2009
REVIEW: Selective autophagy regulates various cellular functions

(2010) Masaaki Komatsu et al.   GENES TO CELLS

Phosphatidylinositol 3-Kinase Facilitates Microtubule-dependent Membrane Transport for Neuronal Growth Cone Guidance

(2010) Hiroki Akiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

(2010) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Leukocyte transmigration is modulated by chemokine-mediated PI3Kγ-dependent phosphorylation of vimentin

(2009) Laura Barberis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Growth factors and cytokines/chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer’s disease and mild cognitive impairment

(2009) Lars Olson et al.   EXPERIMENTAL GERONTOLOGY

Inhibition of PI3K-Akt Signaling Blocks Exercise-Mediated Enhancement of Adult Neurogenesis and Synaptic Plasticity in the Dentate Gyrus

(2009) Elodie Bruel-Jungerman et al.   PLoS One

NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression

(2008) Yulong L. Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Moving towards a Better Understanding of Chemotaxis

(2008) Len Stephens et al.   CURRENT BIOLOGY

Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex

(2008) L. Sui et al.   LEARNING & MEMORY