Screening drugs for myocardial disease in vivo with zebrafish: an expert update

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

Mutation of the Na + /K + -ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish

(2018) Alexander Pott et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning

(2018) Patrick Y. Sips et al.   PLoS One

A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish

(2018) Xiao Ma et al.   Jove-Journal of Visualized Experiments

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

(2018) Cécile Otten et al.   EMBO Molecular Medicine

Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss

(2017) Sarwat Chowdhury et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

(2017) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelial Notch signalling limits angiogenesis via control of artery formation

(2017) Sana S. Hasan et al.   NATURE CELL BIOLOGY

Zebrafish: A promising in vivo model for assessing the delivery of natural products, fluorescence dyes and drugs across the blood-brain barrier

(2017) Ye Li et al.   PHARMACOLOGICAL RESEARCH

Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system

(2017) Yihan Zhang et al.   Nature Communications

Guidelines for morpholino use in zebrafish

(2017) Didier Y. R. Stainier et al.   PLoS Genetics

CRISPR/Cas9 in zebrafish: an efficient combination for human genetic diseases modeling

(2016) Jiaqi Liu et al.   HUMAN GENETICS

Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis

(2016) Alison L. Reynolds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wars2 is a determinant of angiogenesis

(2016) Mao Wang et al.   Nature Communications

Zebrafish heart as a model for human cardiac electrophysiology

(2015) Matti Vornanen et al.   Channels

Contemporary Drug Development in Heart Failure

(2015) Muthiah Vaduganathan et al.   Circulation-Heart Failure

15 years of zebrafish chemical screening

(2015) Andrew J Rennekamp et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cardiovascular Drug Development

(2015) Christopher B. Fordyce et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart

(2015) K.S. Wilson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

CRISPR, the disruptor

(2015) Heidi Ledford   NATURE

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

(2015) Ayal Hendel et al.   NATURE BIOTECHNOLOGY

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

Modeling Disease In Vivo With CRISPR/Cas9

(2015) Lukas E. Dow   TRENDS IN MOLECULAR MEDICINE

Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

(2015) Hirohito Shimizu et al.   eLife

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

(2015) Jun Zou et al.   eLife

Zebrafish as a New Model for Phenotype-based Screening of Positive Inotropic Agents

(2014) Chunlei Tang et al.   Chemical Biology & Drug Design

Functional Genomics in Zebrafish as a Tool to Identify Novel Antiarrhythmic Targets

(2014) A. Pott et al.   CURRENT MEDICINAL CHEMISTRY

The zebrafish as a tool to identify novel therapies for human cardiovascular disease

(2014) A. Asnani et al.   Disease Models & Mechanisms

Scientific and Regulatory Reasons for Delay and Denial of FDA Approval of Initial Applications for New Drugs, 2000-2012

(2014) Leonard V. Sacks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Global Burden of Cardiovascular Disease

(2014) Valentin Fuster   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase

(2014) Y. Liu et al.   Science Translational Medicine

Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy

(2014) A. Asimaki et al.   Science Translational Medicine

Zebrafish Heart Failure Models for the Evaluation of Chemical Probes and Drugs

(2013) Cheng-Chen Huang et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Regulation of expression of atrial and brain natriuretic peptide, biomarkers for heart development and disease

(2013) Irina A. Sergeeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/ -catenin signaling pathway

(2013) Y. Zhang et al.   BLOOD

Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines

(2013) D C Swinney   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hematopoiesis

(2013) M. Jagannathan-Bogdan et al.   DEVELOPMENT

Phenotypic screens as a renewed approach for drug discovery

(2013) Wei Zheng et al.   DRUG DISCOVERY TODAY

Recent advances in in vivo screening for antiarrhythmic drugs

(2013) Calum A MacRae   Expert Opinion on Drug Discovery

Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure

(2013) Anjali K. Nath et al.   FASEB JOURNAL

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Photochemical activation of TRPA1 channels in neurons and animals

(2013) David Kokel et al.   Nature Chemical Biology

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Optimisation of Embryonic and Larval ECG Measurement in Zebrafish for Quantifying the Effect of QT Prolonging Drugs

(2013) Sundeep Singh Dhillon et al.   PLoS One

Advances in zebrafish chemical screening technologies

(2012) Jonathan R Mathias et al.   Future Medicinal Chemistry

Hooked! Modeling human disease in zebrafish

(2012) Cristina Santoriello et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling

(2011) Jason R. Becker et al.   CARDIOVASCULAR RESEARCH

Zebrafish as a model to study cardiac development and human cardiac disease

(2011) J. Bakkers   CARDIOVASCULAR RESEARCH

Promoting Global Cardiovascular Health

(2011) Valentin Fuster et al.   CIRCULATION

Cardiovascular risk assessment of atypical antipsychotic drugs in a zebrafish model

(2011) Sung Hak Lee et al.   JOURNAL OF APPLIED TOXICOLOGY

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

The productivity crisis in pharmaceutical R&D

(2011) Fabio Pammolli et al.   NATURE REVIEWS DRUG DISCOVERY

Identification and expression analysis of kcnh2 genes in the zebrafish

(2010) Ivone Un San Leong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen

(2010) David S. Peal et al.   CIRCULATION

Rosuvastatin, Identified From a Zebrafish Chemical Genetic Screen for Antiangiogenic Compounds, Suppresses the Growth of Prostate Cancer

(2010) Chunyang Wang et al.   EUROPEAN UROLOGY

Cardiac arrhythmia:in vivoscreening in the zebrafish to overcome complexity in drug discovery

(2010) Calum A MacRae   Expert Opinion on Drug Discovery

ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish

(2010) Bin Ren et al.   JOURNAL OF CLINICAL INVESTIGATION

High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish

(2010) Jordan T. Shin et al.   PHYSIOLOGICAL GENOMICS

Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3 , as Regulators of Myocardial Repolarization

(2009) David J. Milan et al.   CIRCULATION

Zebrafish: A Complete Animal Model for In Vivo Drug Discovery and Development

(2009) Chiranjib Chakraborty et al.   CURRENT DRUG METABOLISM

Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase

(2009) Yolanda Alvarez et al.   PLoS One

Zebrafish: an emerging technology forin vivopharmacological assessment to identify potential safety liabilities in early drug discovery

(2008) T P Barros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deficient Zebrafish Ether-à-Go-Go –Related Gene Channel Gating Causes Short-QT Syndrome in Zebrafish Reggae Mutants

(2008) David Hassel et al.   CIRCULATION

Rotation and Asymmetric Development of the Zebrafish Heart Requires Directed Migration of Cardiac Progenitor Cells

(2008) Kelly A. Smith et al.   DEVELOPMENTAL CELL

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

(2008) Stéphane Berghmans et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System

(2008) Neil C Chi et al.   PLOS BIOLOGY

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death

(2008) Kelly N. Owens et al.   PLoS Genetics