Zebrafish as tools for drug discovery

15 years of zebrafish chemical screening

(2015) Andrew J Rennekamp et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion

(2015) V. E. Gallardo et al.   Disease Models & Mechanisms

Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment

(2015) Pulin Li et al.   NATURE

Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing

(2015) Nicole A. Ducharme et al.   REPRODUCTIVE TOXICOLOGY

A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen

(2015) Marja Driessen et al.   TOXICOLOGY LETTERS

PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation

(2015) Anjali K. Nath et al.   Cell Reports

An In Vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog Signaling Inhibition

(2015) Charles H. Williams et al.   Cell Reports

Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

(2015) Kimberley J. Evason et al.   PLoS Genetics

A Zebrafish Chemical Suppressor Screening Identifies Small Molecule Inhibitors of the Wnt/β-catenin Pathway

(2014) Naoyuki Nishiya et al.   CHEMISTRY & BIOLOGY

Neural Crest Development and Craniofacial Morphogenesis Is Coordinated by Nitric Oxide and Histone Acetylation

(2014) Yawei Kong et al.   CHEMISTRY & BIOLOGY

Precise and efficient genome editing in zebrafish using the CRISPR/Cas9 system

(2014) U. Irion et al.   DEVELOPMENT

The zebrafish as a tool to identify novel therapies for human cardiovascular disease

(2014) A. Asnani et al.   Disease Models & Mechanisms

Getting more for your marrow: Boosting hematopoietic stem cell numbers with PGE2

(2014) Elliott J. Hagedorn et al.   EXPERIMENTAL CELL RESEARCH

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Inactivating Mutations in NPC1L1 and Protection from Coronary Heart Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Transient Overexpression of adh8a Increases Allyl Alcohol Toxicity in Zebrafish Embryos

(2014) Nils Klüver et al.   PLoS One

Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

(2014) James A. Gagnon et al.   PLoS One

Whole Organism High Content Screening Identifies Stimulators of Pancreatic Beta-Cell Proliferation

(2014) Naoki Tsuji et al.   PLoS One

Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase

(2014) Y. Liu et al.   Science Translational Medicine

Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy

(2014) A. Asimaki et al.   Science Translational Medicine

Interaction of environmental contaminants with zebrafish organic anion transporting polypeptide, Oatp1d1 (Slco1d1)

(2014) Marta Popovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation

(2013) C. Cutler et al.   BLOOD

AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/ -catenin signaling pathway

(2013) Y. Zhang et al.   BLOOD

Juxtaposition of Chemical and Mutation-Induced Developmental Defects in Zebrafish Reveal a Copper-Chelating Activity for Kalihinol F

(2013) Imelda T. Sandoval et al.   CHEMISTRY & BIOLOGY

A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development

(2013) X. Le et al.   DEVELOPMENT

Hematopoiesis

(2013) M. Jagannathan-Bogdan et al.   DEVELOPMENT

Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure

(2013) Anjali K. Nath et al.   FASEB JOURNAL

Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair

(2013) T. O. Auer et al.   GENOME RESEARCH

Cannabinoid Receptor 2 Suppresses Leukocyte Inflammatory Migration by Modulating the JNK/c-Jun/Alox5 Pathway

(2013) Yi-Jie Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Photochemical activation of TRPA1 channels in neurons and animals

(2013) David Kokel et al.   Nature Chemical Biology

Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish

(2013) An Xiao et al.   NUCLEIC ACIDS RESEARCH

Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval Zebrafish

(2013) Angeleen Fleming et al.   PLoS One

A Phenotypic Screen in Zebrafish Identifies a Novel Small-Molecule Inducer of Ectopic Tail Formation Suggestive of Alterations in Non-Canonical Wnt/PCP Signaling

(2013) Evelien Gebruers et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment

(2013) Scott C. Baraban et al.   Nature Communications

Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen

(2013) Jijun Hao et al.   Cell Reports

A Chemical Screening System for Glucocorticoid Stress Hormone Signaling in an Intact Vertebrate

(2012) Benjamin D. Weger et al.   ACS Chemical Biology

Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis

(2012) Matthias Derwall et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Zebrafish screen identifies novel compound with selective toxicity against leukemia

(2012) S. Ridges et al.   BLOOD

Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR

(2012) Jared J. Ganis et al.   DEVELOPMENTAL BIOLOGY

Identification of Modulators of Hair Cell Regeneration in the Zebrafish Lateral Line

(2012) P. Namdaran et al.   JOURNAL OF NEUROSCIENCE

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism

(2012) Philipp Gut et al.   Nature Chemical Biology

Small molecule screening identifies targetable zebrafish pigmentation pathways

(2012) Sarah Colanesi et al.   Pigment Cell & Melanoma Research

Pharmacological Suppression of Hepcidin Increases Macrophage Cholesterol Efflux and Reduces Foam Cell Formation and Atherosclerosis

(2011) Omar Saeed et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A high-content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling

(2011) Manush Saydmohammed et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

(2011) I. Theurl et al.   BLOOD

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

(2011) A. U. Steinbicker et al.   BLOOD

In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling

(2011) Jason R. Becker et al.   CARDIOVASCULAR RESEARCH

The bone morphogenetic protein–hepcidin axis as a therapeutic target in inflammatory bowel disease

(2011) Lijian Wang et al.   INFLAMMATORY BOWEL DISEASES

Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia

(2011) Virginia M. Klimek et al.   LEUKEMIA RESEARCH

Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae

(2011) Zhen Hua Li et al.   Molecular BioSystems

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development

(2011) Karun K. Singh et al.   NEURON

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation

(2011) M. Rovira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical modulation of memory formation in larval zebrafish

(2011) M. A. Wolman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish developmental screening of the ToxCast™ Phase I chemical library

(2011) S. Padilla et al.   REPRODUCTIVE TOXICOLOGY

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

(2010) Jared V Goldstone et al.   BMC GENOMICS

Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen

(2010) David S. Peal et al.   CIRCULATION

Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation

(2010) H. Ishizaki et al.   Disease Models & Mechanisms

Rosuvastatin, Identified From a Zebrafish Chemical Genetic Screen for Antiangiogenic Compounds, Suppresses the Growth of Prostate Cancer

(2010) Chunyang Wang et al.   EUROPEAN UROLOGY

ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish

(2010) Bin Ren et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

(2010) David Kokel et al.   Nature Chemical Biology

High-resolution cardiovascular function confirms functional orthology of myocardial contractility pathways in zebrafish

(2010) Jordan T. Shin et al.   PHYSIOLOGICAL GENOMICS

Identification of Novel Inhibitors of Dietary Lipid Absorption Using Zebrafish

(2010) Justin D. Clifton et al.   PLoS One

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

(2010) J. Rihel et al.   SCIENCE

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

Zebrafish pancreas development

(2009) Natascia Tiso et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

(2009) Gabriela Molina et al.   Nature Chemical Biology

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation

(2009) Jing-Ruey J Yeh et al.   Nature Chemical Biology

Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models

(2009) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

(2008) Gregory D. Cuny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

BMP type I receptor inhibition reduces heterotopic ossification

(2008) Paul B Yu et al.   NATURE MEDICINE

Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System

(2008) Neil C Chi et al.   PLOS BIOLOGY

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death

(2008) Kelly N. Owens et al.   PLoS Genetics

Functional and developmental analysis of the blood–brain barrier in zebrafish

(2007) Jae-Yeon Jeong et al.   BRAIN RESEARCH BULLETIN