Phenotype-based Discovery of 2-[(E)-2-(Quinolin-2-yl)vinyl]phenol as a Novel Regulator of Ocular Angiogenesis

15 years of zebrafish chemical screening

(2015) Andrew J Rennekamp et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Abnormal retinal development inClochemutant zebrafish

(2015) Susov Dhakal et al.   DEVELOPMENTAL DYNAMICS

The peptidomimetic Vasotide targets two retinal VEGF receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal disease

(2015) Richard L. Sidman et al.   Science Translational Medicine

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

(2015) Julia Marschallinger et al.   Nature Communications

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

(2014) Magnus Bäck et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vivo analysis of hyaloid vasculature morphogenesis in zebrafish: A role for the lens in maturation and maintenance of the hyaloid

(2014) Andrea Hartsock et al.   DEVELOPMENTAL BIOLOGY

Opioid Receptor Function Is Regulated by Post-endocytic Peptide Processing

(2014) Achla Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering Combinations of PI3K/AKT/mTOR Pathway Drugs Augmenting Anti-Angiogenic Efficacy In Vivo

(2014) Temitope Sasore et al.   PLoS One

Cysteinyl leukotrienes and their receptors: Bridging inflammation and colorectal cancer

(2014) Sayeh Savari   WORLD JOURNAL OF GASTROENTEROLOGY

Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts

(2014) Yoshihide Kanaoka et al.   Allergy Asthma & Immunology Research

The inflammatory mediator leukotriene D4 induces subcellular β-catenin translocation and migration of colon cancer cells

(2013) Tavga Salim et al.   EXPERIMENTAL CELL RESEARCH

Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E4Ligand

(2013) Yoshihide Kanaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinopathy of prematurity

(2013) Ann Hellström et al.   LANCET

Leukotriene D4 induces amyloid-β generation via CysLT1R-mediated NF-κB pathways in primary neurons

(2013) Xiao Yun Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Seven-Year Outcomes in Ranibizumab-Treated Patients in ANCHOR, MARINA, and HORIZON

(2013) Soraya Rofagha et al.   OPHTHALMOLOGY

CysLT1R Antagonists Inhibit Tumor Growth in a Xenograft Model of Colon Cancer

(2013) Sayeh Savari et al.   PLoS One

Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT2 and CysLT1 receptors

(2013) Ernest Duah et al.   Scientific Reports

Asthma Treatment Outcome in Children Is Associated with Vascular Endothelial Growth Factor A (VEGFA) Polymorphisms

(2012) Mateja Balantic et al.   Molecular Diagnosis & Therapy

Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration

(2012) Jeffrey S. Heier et al.   OPHTHALMOLOGY

Intravitreal Ranibizumab for Diabetic Macular Edema with Prompt versus Deferred Laser Treatment

(2012) Michael J. Elman et al.   OPHTHALMOLOGY

Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain

(2012) N. Kyritsis et al.   SCIENCE

The cysteinyl leukotriene 2 receptor mediates retinal edema and pathological neovascularization in a murine model of oxygen-induced retinopathy

(2011) Alma Barajas-Espinosa et al.   FASEB JOURNAL

Clinical Development of Vascular Disrupting Agents: What Lessons Can We Learn From ASA404?

(2011) Patricia M. LoRusso et al.   JOURNAL OF CLINICAL ONCOLOGY

Use of the mouse aortic ring assay to study angiogenesis

(2011) Marianne Baker et al.   Nature Protocols

Ranibizumab and Bevacizumab for Neovascular Age-Related Macular Degeneration

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: Involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathways

(2010) Min Hee Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Retinal vein thrombosis: pathogenesis and management

(2010) M. REHAK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Cysteinyl Leukotrienes and Their Receptors: Molecular and Functional Characteristics

(2010) R.K. Singh et al.   PHARMACOLOGY

Combination of Reverse and Chemical Genetic Screens Reveals Angiogenesis Inhibitors and Targets

(2009) Mattias Kalén et al.   CHEMISTRY & BIOLOGY

Persistent hyperplastic primary vitreous: congenital malformation of the eye

(2009) Barkur S Shastry   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Leukotriene D4 Stimulates the Migration but Not Proliferation of Endothelial Cells Mediated by the Cysteinyl Leukotriene CysLT1 Receptor via the Extracellular Signal-Regulated Kinase Pathway

(2009) Yu-Mei Yuan et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Small molecule screen for compounds that affect vascular development in the zebrafish retina

(2009) Satish S. Kitambi et al.   MECHANISMS OF DEVELOPMENT

Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis

(2009) Kip M Connor et al.   Nature Protocols

Selective Inhibition of Retinal Angiogenesis by Targeting PI3 Kinase

(2009) Yolanda Alvarez et al.   PLoS One

Homology Modeling and Site-Directed Mutagenesis To Identify Selective Inhibitors of Endothelin-Converting Enzyme-2

(2008) Khatuna Gagnidze et al.   JOURNAL OF MEDICINAL CHEMISTRY

Age-Related Macular Degeneration

(2008) Rama D. Jager et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors

(2008) A. Maekawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA