4-Hydroxy-2-nonenal: a critical target in oxidative stress?

Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression

(2016) Lakshmi Galam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Membrane lipid peroxidation in neurodegeneration: Role of thrombin and proteinase-activated receptor-1

(2016) Bruce A. Citron et al.   BRAIN RESEARCH

Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression

(2016) Jeannie M. Camarillo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Alda-1 Attenuates Lung Ischemia-Reperfusion Injury by Reducing 4-Hydroxy-2-Nonenal in Alveolar Epithelial Cells

(2016) Jie Ding et al.   CRITICAL CARE MEDICINE

Deletion of ASK1 Protects against Hyperoxia-Induced Acute Lung Injury

(2016) Jutaro Fukumoto et al.   PLoS One

Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability

(2015) Simona Gargiulo et al.   AGING CELL

The role of antioxidants in the chemistry of oxidative stress: A review

(2015) Aurelia Magdalena Pisoschi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

(2015) Maria Hytti et al.   EXPERIMENTAL EYE RESEARCH

Oxidative stress and human spermatozoa: diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation

(2015) Ryan Moazamian et al.   MOLECULAR HUMAN REPRODUCTION

4-Hydroxynonenal regulates mitochondrial function in human small airway epithelial cells

(2015) Lakshmi Galam et al.   Oncotarget

Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria

(2015) Huiqin Zhong et al.   Redox Biology

Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts

(2014) Sobia Iqbal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Involvement of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in BDNF signaling during aging and in Alzheimer disease: Possible role of 4-hydroxynonenal (4-HNE)

(2014) Elisabetta Benedetti et al.   CELL CYCLE

Impairment of aldehyde dehydrogenase-2 by 4-hydroxy-2-nonenal adduct formation and cardiomyocyte hypertrophy in mice fed a high-fat diet and injected with low-dose streptozotocin

(2014) Vishal R Mali et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

4-Hydroxy-2-nonenal Induces Apoptosis by Inhibiting AKT Signaling in Human Osteosarcoma Cells

(2014) Guang-rong Ji et al.   TheScientificWorldJOURNAL

S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry

(2014) James Mike Brown et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NLRP3 deletion protects from hyperoxia-induced acute lung injury

(2013) Jutaro Fukumoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

(2013) S Dalleau et al.   CELL DEATH AND DIFFERENTIATION

4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases

(2013) Mohammad Shoeb et al.   CURRENT MEDICINAL CHEMISTRY

Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes

(2013) Guy Cohen et al.   FREE RADICAL BIOLOGY AND MEDICINE

4-Hydroxynonenal Induces G2/M Phase Cell Cycle Arrest by Activation of the Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR)/Checkpoint Kinase 1 (Chk1) Signaling Pathway

(2013) Pankaj Chaudhary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes

(2013) Si-Hai Fu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Thioredoxin and Thioredoxin Target Proteins: From Molecular Mechanisms to Functional Significance

(2012) Samuel Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

ALDH2 Activator Inhibits Increased Myocardial Infarction Injury by Nitroglycerin Tolerance

(2011) L. Sun et al.   Science Translational Medicine

Reactive oxygen species and α,β-unsaturated aldehydes as second messengers in signal transduction

(2010) Henry Jay Forman   Annals of the New York Academy of Sciences

Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

(2010) Pankaj Chaudhary et al.   BIOCHEMISTRY

Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells

(2010) Rit Vatsyayan et al.   EXPERIMENTAL EYE RESEARCH

Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease

(2010) M.A. Bradley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant

(2010) Samantha Perez-Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Potential Therapeutic Benefits of Strategies Directed to Mitochondria

(2009) Amadou K.S. Camara et al.   ANTIOXIDANTS & REDOX SIGNALING

Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD

(2009) Tanea T. Reed et al.   BRAIN RESEARCH

Products of Oxidative Stress Inhibit Aldehyde Oxidation and Reduction Pathways in Dopamine Catabolism Yielding Elevated Levels of a Reactive Intermediate

(2009) Yunden Jinsmaa et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal

(2008) Henry Jay Forman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation

(2008) Vian Azzu et al.   BIOCHEMICAL JOURNAL

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

(2007) A Negre-Salvayre et al.   BRITISH JOURNAL OF PHARMACOLOGY