Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress

(2013) Joshua K. Salabei et al.   BIOCHEMICAL JOURNAL

Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links

(2013) E. A. Perry et al.   FREE RADICAL RESEARCH

Mitochondrial aldehyde dehydrogenase-2 activation prevents  -amyloid-induced endothelial cell dysfunction and restores angiogenesis

(2013) R. Solito et al.   JOURNAL OF CELL SCIENCE

Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression

(2013) L Buizza et al.   Cell Death & Disease

Inhibition of NF-κB Activation by 4-Hydroxynonenal Contributes to Liver Injury in a Mouse Model of Alcoholic Liver Disease

(2012) Xiaobing Dou et al.   AMERICAN JOURNAL OF PATHOLOGY

Lack of p53 Decreases Basal Oxidative Stress Levels in the Brain Through Upregulation of Thioredoxin-1, Biliverdin Reductase-A, Manganese Superoxide Dismutase, and Nuclear Factor Kappa-B

(2012) Eugenio Barone et al.   ANTIOXIDANTS & REDOX SIGNALING

Naturally Occurring Variation in the Glutathione-S-Transferase 4 Gene Determines Neurodegeneration After Traumatic Brain Injury

(2012) Faiez Al Nimer et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

(2012) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Disulfide Isomerase Modification and Inhibition Contribute to ER Stress and Apoptosis Induced by Oxidized Low Density Lipoproteins

(2012) Carole Muller et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Short-term exposure of 4-hydroxynonenal induces mitochondria-mediated apoptosis in PC12 cells

(2012) MA Siddiqui et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Lipid Peroxidation Product 4-Hydroxy-trans-2-nonenal Causes Endothelial Activation by Inducing Endoplasmic Reticulum Stress

(2012) Elena Vladykovskaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE)

(2012) Cagri Bodur et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Characterization of 4-HNE Modified L-FABP Reveals Alterations in Structural and Functional Dynamics

(2012) Rebecca L. Smathers et al.   PLoS One

The pantheon of the fallen: why are there so many forms of cell death?

(2012) Douglas R. Green et al.   TRENDS IN CELL BIOLOGY

4-Hydroxy-2(E)-nonenal Metabolism Differs in Apc+/+Cells and in ApcMin/+Cells: It May Explain Colon Cancer Promotion by Heme Iron

(2011) Maryse Baradat et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nuclear factor erythroid 2-related factor-2 activity controls 4-hydroxynonenal metabolism and activity in prostate cancer cells

(2011) Piergiorgio Pettazzoni et al.   FREE RADICAL BIOLOGY AND MEDICINE

4-Hydroxy-2-Nonenal Mediates Genotoxicity and Bystander Effects Caused by Enterococcus faecalis–Infected Macrophages

(2011) Xingmin Wang et al.   GASTROENTEROLOGY

Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis

(2011) Peeter Karihtala et al.   HISTOPATHOLOGY

Modulation of Aldehyde Dehydrogenase Activity Affects (±)-4-Hydroxy-2E-nonenal (HNE) Toxicity and HNE–Protein Adduct Levels in PC12 Cells

(2011) Dehe Kong et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Protein modification and replicative senescence of WI-38 human embryonic fibroblasts

(2010) Emad K. Ahmed et al.   AGING CELL

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling

(2010) Pankaj Chaudhary et al.   BIOCHEMISTRY

Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells

(2010) Tim U. Krohne et al.   EXPERIMENTAL EYE RESEARCH

Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death

(2010) Nikolaus Bresgen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition

(2010) Wei Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats

(2010) Adriana Marquez-Quiñones et al.   FREE RADICAL RESEARCH

Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

(2010) Shruti Singh et al.   FREE RADICAL RESEARCH

Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation

(2009) Rajat Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Piceatannol Attenuates 4-Hydroxynonenal-Induced Apoptosis of PC12 Cells by Blocking Activation of c-Jun N-Terminal Kinase

(2009) Young Jin Jang et al.   Annals of the New York Academy of Sciences

Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase

(2009) Célio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

(2009) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders

(2009) Mark P. Mattson   EXPERIMENTAL GERONTOLOGY

The role of c-Jun phosphorylation in EpRE activation of phase II genes

(2009) Smadar Levy et al.   FREE RADICAL BIOLOGY AND MEDICINE

HSF1-mediated BAG3 Expression Attenuates Apoptosis in 4-Hydroxynonenal-treated Colon Cancer Cells via Stabilization of Anti-apoptotic Bcl-2 Proteins

(2009) Aaron T. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

4-Hydroxynonenal, a lipid peroxidation product of dietary polyunsaturated fatty acids, has anticarcinogenic properties in colon carcinoma cell lines through the inhibition of telomerase activity

(2009) Stefania Pizzimenti et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Disruption of the mGsta4 Gene Increases Life Span of C57BL Mice

(2009) S. P. Singh et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Signaling pathways involved in phase II gene induction by α, β-unsaturated aldehydes

(2009) Hongqiao Zhang et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice

(2008) Melissa Braga et al.   APOPTOSIS

4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells

(2008) Abha Sharma et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells

(2008) Bradford G. Hill et al.   BIOCHEMICAL JOURNAL

The extrinsic cell death pathway and the élan mortel

(2008) D Wallach et al.   CELL DEATH AND DIFFERENTIATION

No death without life: vital functions of apoptotic effectors

(2008) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Measurement of oxidative stress and antioxidant status in acute lymphoblastic leukemia patients

(2008) Vanessa Battisti et al.   CLINICAL BIOCHEMISTRY

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

Glutathione and apoptosis

(2008) Magdalena L. Circu et al.   FREE RADICAL RESEARCH

Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE,in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease

(2008) Giovanna Cenini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chronic treatment with N-acetyl-cystein delays cellular senescence in endothelial cells isolated from a subgroup of atherosclerotic patients

(2008) Guillaume Voghel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity

(2008) Vittorio Calabrese et al.   NEUROCHEMICAL RESEARCH

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase

(2008) France Vaillancourt et al.   ARTHRITIS RESEARCH & THERAPY

4-Hydroxynonenal Self-Limits Fas-Mediated DISC-Independent Apoptosis by Promoting Export of Daxx from the Nucleus to the Cytosol and Its Binding to Fas†

(2007) Rajendra Sharma et al.   BIOCHEMISTRY

4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interest

(2007) G. Poli et al.   MEDICINAL RESEARCH REVIEWS