ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome

A critical epitope in CD147 facilitates memory CD4+ T-cell hyper-activation in rheumatoid arthritis

(2018) Na Guo et al.   Cellular & Molecular Immunology

Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation

(2017) Fawaz Awad et al.   PLoS One

CD147 modulates the differentiation of T-helper 17 cells in patients with rheumatoid arthritis

(2016) Hui Yang et al.   APMIS

The role of anticitrullinated protein antibodies in the early stages of rheumatoid arthritis

(2016) Jacqueline Dekkers et al.   CURRENT OPINION IN RHEUMATOLOGY

Human Monocytes Engage an Alternative Inflammasome Pathway

(2016) Moritz M. Gaidt et al.   IMMUNITY

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis

(2016) Anca I. Catrina et al.   Nature Reviews Rheumatology

Anti-citrullinated protein antibodies suppress let-7a expression in monocytes from patients with rheumatoid arthritis and facilitate the inflammatory responses in rheumatoid arthritis

(2015) Ning-Sheng Lai et al.   IMMUNOBIOLOGY

CD147 promotes IKK/IκB/NF-κB pathway to resist TNF-induced apoptosis in rheumatoid arthritis synovial fibroblasts

(2015) Yue Zhai et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CD147 and CD98 complex-mediated homotypic aggregation attenuates the CypA-induced chemotactic effect on Jurkat T cells

(2015) Na Guo et al.   MOLECULAR IMMUNOLOGY

The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction

(2015) Leanne Mortimer et al.   PLoS Pathogens

IgM rheumatoid factor amplifies the inflammatory response of macrophages induced by the rheumatoid arthritis-specific immune complexes containing anticitrullinated protein antibodies

(2014) Lætitia Laurent et al.   ANNALS OF THE RHEUMATIC DISEASES

Enhancement of CD147 on M1 macrophages induces differentiation of Th17 cells in the lung interstitial fibrosis

(2014) Jie-jie Geng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

HAb18G/CD147 Promotes Radioresistance in Hepatocellular Carcinoma Cells: A Potential Role for Integrin  1 Signaling

(2014) J. Wu et al.   MOLECULAR CANCER THERAPEUTICS

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Rheumatoid Factor as a Potentiator of Anti-Citrullinated Protein Antibody-Mediated Inflammation in Rheumatoid Arthritis

(2014) Jeremy Sokolove et al.   Arthritis & Rheumatology

Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis

(2013) Parawee Suwannalai et al.   ANNALS OF THE RHEUMATIC DISEASES

Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment

(2013) Rebeccah J Mathews et al.   ANNALS OF THE RHEUMATIC DISEASES

Determinants of Mortality Among Postmenopausal Women in the Women's Health Initiative Who Report Rheumatoid Arthritis

(2013) Lewis H. Kuller et al.   Arthritis & Rheumatology

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular Membrane-proximal Domain of HAb18G/CD147 Binds to Metal Ion-dependent Adhesion Site (MIDAS) Motif of Integrin β1 to Modulate Malignant Properties of Hepatoma Cells

(2011) Yong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

State-of-the-art: rheumatoid arthritis

(2010) I. B. McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Anti-citrullinated protein antibodies bind surface-expressed citrullinated Grp78 on monocyte/macrophages and stimulate tumor necrosis factor α production

(2010) Ming-Chi Lu et al.   ARTHRITIS AND RHEUMATISM

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Expression of CD147 (EMMPRIN) on neutrophils in rheumatoid arthritis enhances chemotaxis, matrix metalloproteinase production and invasiveness of synoviocytes

(2010) Cong-Hua Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-κB andMKK7/JNK/AP-1 signaling

(2010) Balachandar Venkatesan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins

(2010) Katleen Van Steendam et al.   ARTHRITIS RESEARCH & THERAPY

The interaction of HAb18G/CD147 with integrin α6β1 and its implications for the invasion potential of human hepatoma cells

(2009) Jing-yao Dai et al.   BMC CANCER

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

Inhibitory effect of CD147/HAb18 monoclonal antibody on cartilage erosion and synovitis in the SCID mouse model for rheumatoid arthritis

(2009) J. Jia et al.   RHEUMATOLOGY

Parallel kinetic analysis and affinity determination of hundreds of monoclonal antibodies using the ProteOn XPR36

(2008) Oded Nahshol et al.   ANALYTICAL BIOCHEMISTRY

Induction of macrophage secretion of tumor necrosis factor α through Fcγ receptor IIa engagement by rheumatoid arthritis–specific autoantibodies to citrullinated proteins complexed with fibrinogen

(2008) Cyril Clavel et al.   ARTHRITIS AND RHEUMATISM

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION