Article
Oncology
Ming-Fang Wu, Chih-An Lin, Tzu-Hang Yuan, Hsiang-Yuan Yeh, Sheng-Fang Su, Chin-Lin Guo, Gee-Chen Chang, Ker-Chau Li, Chao-Chi Ho, Huei-Wen Chen
Summary: The study identified the M1/M2 spectrum and plasticity of MPE-Mϕ, and described a two-gene M1/M2 signature that can predict outcomes of late-stage lung cancer patients. Furthermore, re-educating MPE-Mϕ towards anti-cancer M1 macrophages using clinically applicable strategies may overcome tumor immune escape and benefit anti-cancer therapies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Cell Biology
Minto Nakagawa, Mohammad Rabiul Karim, Takeshi Izawa, Mitsuru Kuwamura, Jyoji Yamate
Summary: Renal fibrosis is considered as a common final pathway in chronic kidney diseases, where macrophages and myofibroblasts play crucial roles; the interaction between M1/M2 macrophages and CD4/CD8 T cells contributes to the progressive development of renal interstitial fibrosis.
Review
Medicine, Research & Experimental
Zuzana Strizova, Iva Benesova, Robin Bartolini, Rene Novysedlak, Eva Cecrdlova, Lily Koumbas Foley, Ilja Striz
Summary: Macrophages are a heterogeneous cell population with various roles in defense mechanisms and tissue homeostasis. They can adopt different activation states depending on the microenvironment and natural signals they receive.
Article
Endocrinology & Metabolism
Yinhua Ni, Fen Zhuge, Liyang Ni, Naoto Nagata, Tatsuya Yamashita, Naofumi Mukaida, Shuichi Kaneko, Tsuguhito Ota, Mayumi Nagashimada
Summary: This study investigates the roles of CX3CL1/CX3CR1 in macrophage migration and polarization in the livers of NASH mice. It is found that CX3CL1 and CX3CR1 expression is upregulated in NASH mice livers, and CX3CR1 is predominantly expressed by F4/80+ macrophages. CX3CR1 deficiency leads to increased inflammatory monocyte/macrophage infiltration and a shift towards M1 dominant macrophages, exacerbating NASH progression. Deletion of CCL2 in CX3CR1-deficient mice alleviates NASH progression by reducing macrophage infiltration and inducing a shift towards M2 dominant macrophages.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Anatomy & Morphology
Hengfang Zhang, Shuang Zhang, Xuan Dang, Lexun Lin, Liping Ren, Rong Song
Summary: Macrophages play a crucial role in the development of periodontitis and their phenotype is influenced by GPNMB protein. Overexpression of GPNMB in macrophages was found to enhance the secretion of anti-inflammatory factors and inhibit the secretion of pro-inflammatory factors.
Review
Oncology
Jiuyang Liu, Xiafei Geng, Jinxuan Hou, Gaosong Wu
Summary: This article examines the critical roles of M1 and M2 macrophages in tumor progression, with M1 possessing anti-tumor properties and M2 promoting tumor growth and metastasis.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Sofia Liborio-Ramos, Catarina Barbosa-Matos, Raquel Fernandes, Caroline Borges-Pereira, Sandra Costa
Summary: In lung diseases, a progressive fibrosing phenotype plays a critical role and is associated with high mortality. Pulmonary macrophages have been found to modulate fibrotic processes. In this study, we aimed to characterize the different macrophage populations and their effect on fibroblast activation in the early stages of bleomycin-induced pulmonary fibrosis.
Article
Medicine, Research & Experimental
Hong Zhen, Hongbo Hu, Guojie Rong, Xiuxiu Huang, Chang Tan, Xinyuan Yu
Summary: Administration of vitamin A or vitamin D can alleviate BPD-linked pulmonary injury induced by LPS and have a significant impact on macrophage polarization.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Antong Wu, Janak Lal. Pathak, Xingyang Li, Wei Cao, Wenchao Zhong, Mingjing Zhu, Qiuyu Wu, Wanyi Chen, Qiao Han, Siqing Jiang, Yuzhuo Hei, Ziyi Zhang, Gang Wu, Qingbin Zhang
Summary: In this study, the efficacy of human salivary peptide histatin-1 (Hst1) in attenuating bone and cartilage damage in osteoarthritis (OA) was investigated. Hst1 was found to significantly attenuate cartilage and bone deconstruction as well as macrophage infiltration. It also triggered M1-to-M2 macrophage phenotype switching and restored the metabolic activity, migration, and chondrogenic differentiation of chondrogenic cells.
Article
Biochemistry & Molecular Biology
Takuya Kotani, Masaki Ikemoto, Shogo Matsuda, Ryota Masutani, Tohru Takeuchi
Summary: In this study, it was found that the hybrid protein hMIKO-1 can suppress the abnormal activation of macrophages, reduce lung fibrosis in mice, and decrease the expression of related inflammation factors, indicating its potential as a therapeutic candidate for ILD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Wael M. Seoudy, Sara M. Mohy El Dien, Talal A. Abdel Reheem, Mona M. Elfangary, Moatasem A. Erfan
Summary: This study suggests that M1 and M2 macrophages play important roles in the pathogenesis of keloid formation. Keloid formation might be a result of an abnormal response to tissue injury with excessive entry of inflammatory cells, including macrophages, into the wound, and the incidence of keloid might be related to a decrease in M1 and an increase in M2.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Sathuwarman Raveenthiraraj, Griselda Awanis, Marcello Chieppa, Amy E. O'Connell, Anastasia Sobolewski
Summary: This study demonstrates the different effects of homeostatic and inflammatory macrophages on the colonic epithelium. Inflammatory macrophages reduce the numbers of goblet and tuft cells and increase the numbers of stem cells in the crypt, while homeostatic macrophages promote crypt cell proliferation through physical contact. The findings highlight the importance of understanding cellular interactions and immune cell subtypes in crypt cell biology during inflammation.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Immunology
Xiaoyan Wang, Ping Jia, Ting Ren, Zhouping Zou, Sujuan Xu, Yunlu Zhang, Yiqin Shi, Siyu Bao, Yingxiang Li, Yi Fang, Xiaoqiang Ding
Summary: This study reveals the involvement of miR-382 in macrophage activation during AA-induced kidney fibrosis. Knockout of miR-382 inhibits M2-like macrophage activation and kidney interstitial fibrosis, while overexpression of miR-382 promotes kidney injury. The findings highlight the important role of miR-382 in regulating kidney fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Benxin Gong, Ying Zheng, Jiahua Li, Huafeng Lei, Kexin Liu, Jingyun Tang, Yanrong Peng
Summary: This study found that luteolin promotes M2 macrophage polarization and inhibits M1 macrophage polarization, while glycyrrhizic acid does not have these effects. Furthermore, it was discovered that luteolin achieves this regulation by upregulating the expression of hsa_circ_0001326.
Article
Cell Biology
Guang-Ping Lang, Can Li, Ying-Ying Han
Summary: Pretreatment with rutin can promote the phenotypic switch of microglia from M1 to M2 by inhibiting the Toll-like receptor 4/nuclear factor-κB signaling pathway to alleviate lipopolysaccharide-induced neuroinflammation.
NEURAL REGENERATION RESEARCH
(2021)
Review
Oncology
Yiming Li, Juan Tang, Jianli Jiang, Zhinan Chen
Summary: Immunotherapy has achieved significant success in treating cancer, but resistance to this treatment often occurs due to the complex metabolic networks in the tumor microenvironment. Metabolic checkpoints play a crucial role in regulating T cell development, differentiation, and function, as well as coordinating metabolic competition between tumor cells and infiltrating T cells. Thus, targeting metabolic checkpoints may enhance the efficacy of immunotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Chen, Gang Nan, Ding Wei, Ren-You Zhai, Ming Huang, Wu-Wei Yang, Bao-Cai Xing, Xu Zhu, Hai-Feng Xu, Xiao-Dong Wang, Xiao-Yong Zhang, Bao-Rang Zhu, Peng Liu, Guang Cao, Song Gao, Chun-Yi Hao, Ren-Jie Yang, Jian-Hai Guo, Xin Zhang, Kun Gao, Kun Wang, Jian-Feng Wang, Zi-Yu Li, Lin-Zhong Zhu, Rong Ding, Jing Li, Ling Zhao, Yu-Jun Shao, Hai-Chun Liu, Jie-Lai Xia, Ling Wang, Ling-Min Kong, Zhi-Nan Chen, Huijie Bian
Summary: In the adjuvant treatment of unresectable hepatocellular carcinoma, the combination of TACE and I-131-MabThera showed superior antirecurrence efficacy, significantly improved 5-year survival rate of patients, and was well tolerated.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Editorial Material
Cell Biology
Huijie Bian, Ye-Mao Liu, Zhi-Nan Chen
Summary: Two recent studies have found new strategies for ACC targeting in NASH therapy, successfully resolving the unwanted side effects of ACC inhibitors and bringing new hope to NASH treatment.
Article
Immunology
JieJie Geng, Ruo Chen, Feng-fan Yang, Peng Lin, Yu-meng Zhu, Xianghui Fu, Ke Wang, Zhuan Feng, Jiao Wu, Hai Zhang, Qi-jing Li, Zhi-Nan Chen, Ping Zhu
Summary: The study demonstrates that the interaction between CD147 and CD98 in the surrounding environment plays a crucial role in reinforcing Foxp3-dependent Treg stability. Tregs with high CD147 expression effectively inhibit inflammatory responses and maintain Foxp3 stability, which has implications for immunotherapy.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Qi Yuan, Jie Zhang, Yu Liu, Haiqiang Chen, Haiyang Liu, Jinyan Wang, Meng Niu, Lingling Hou, Zhenlong Wu, Zhinan Chen, Jinhua Zhang
Summary: MyD88 in myofibroblasts plays a critical role in promoting hepatocellular carcinoma by affecting aerobic glycolysis in cancer cells. MyD88 deficiency in myofibroblasts attenuates liver fibrosis and liver cancer tissue. Mechanistically, MyD88 signaling in myofibroblasts increases the secretion of CCL20, which promotes aerobic glycolysis in cancer cells. This process is dependent on the CCR6 receptor and ERK/PKM2 signaling.
JOURNAL OF PATHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gang Nan, Shu-Hua Zhao, Ting Wang, Dong Chao, Ruo-Fei Tian, Wen-Jing Wang, Xin Fu, Peng Lin, Ting Guo, Bin Wang, Xiu-Xuan Sun, Xi Chen, Zhi-Nan Chen, Shi-Jie Wang, Hong-Yong Cui
Summary: This study investigates the role and mechanisms of CD147 in paclitaxel resistance. It demonstrates that CD147 protects cancer cells from paclitaxel-induced apoptosis and interacts with the C-terminal tail of RanBP1 to regulate microtubule stability and dynamics as well as response to paclitaxel treatment. Targeting CD147 may be a potential strategy for preventing paclitaxel resistance.
Article
Biochemistry & Molecular Biology
Cheng-Gong Liao, Xiao-Hua Liang, Yuan Ke, Li Yao, Man Liu, Ze-Kun Liu, Lin He, Yi-Xiao Guo, Huijie Bian, Zhi-Nan Chen, Ling-Min Kong
Summary: This study reveals that active demethylation of CD147 is involved in the metastasis of non-small cell lung cancer (NSCLC), and targeted methylation of CD147 can inhibit the invasion and metastasis of NSCLC, providing a promising therapeutic target for NSCLC.
Article
Oncology
Xiao-Hong Chen, Ruo Chen, Ming-Yan Shi, Ruo-Fei Tian, Hai Zhang, Zhi-Qian Xin, Zhi-Nan Chen, Ke Wang
Summary: This study evaluated the significant role of CD147 in NSCLC through bioinformatics analysis and confirmed the efficacy and safety of CD147-CART cells in treating NSCLC through experiments.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Jiao Wu, Zhuan Feng, Liang Chen, Yong Li, Huijie Bian, Jiejie Geng, Zhao-Hui Zheng, Xianghui Fu, Zhuo Pei, Yifei Qin, Liu Yang, Yilin Zhao, Ke Wang, Ruo Chen, Qian He, Gang Nan, Xuejun Jiang, Zhi-Nan Chen, Ping Zhu
Summary: In this study, the authors use a mouse model of rheumatoid arthritis (RA) and single-cell RNA sequencing to show that inducing ferroptosis and suppressing TNF signaling can reduce the number of fibroblasts in the synovium and improve experimental arthritis. They further identify two groups of fibroblasts with distinct susceptibility to ferroptosis and show that TNF signaling protects fibroblasts from ferroptosis through promoting cystine uptake and glutathione biosynthesis. Finally, the combination of low-dose ferroptosis inducer and TNF antagonist attenuates arthritis progression in the mouse model.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Ming Zheng, Yi-Ming Li, Zhen-Yu Liu, Xin Zhang, Yinghui Zhou, Jian-Li Jiang, Ping Zhu, Xiang-Min Yang, Juan Tang, Zhi-Nan Chen
Summary: Immunotherapy targeting tumor-infiltrating lymphocytes has shown promising potential as a treatment for various cancers, but its efficacy varies across different cancer types and patients. The distribution of TIL-T and TIL-B cells and their interactions with the tumor microenvironment play a crucial role in determining the clinical outcomes. Understanding the prognostic significance of these factors can have important implications for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Nai-Shan Zheng, Xiang-Yu Zhao, Ding Wei, Jin-Lin Miao, Ze-Kun Liu, Yu-Le Yong, Ren-Yu Zhang, Yi-Xiao Guo, Lin He, Bin Wang, Xiu-Xuan Sun, Hai-Jiao Yang, Tian-Jiao Zhang, Qian He, Xiao-Min Li, Hai Zhang, Rong Hou, Peng Lin, Ying-Ming Xu, Xiao-Jun Huang, Zhi-Nan Chen, Huijie Bian
Summary: CD147-CAR T cell therapy shows potent anti-tumor activity against T cell acute lymphoblastic leukemia (T-ALL) and potential safety towards normal cells and CD147-deficient cells.
Article
Immunology
Yun-Qi Zhou, Ke Wang, Xue-Yan Wang, Hong-Yong Cui, Yongxiang Zhao, Ping Zhu, Zhi-Nan Chen
Summary: This study reveals that SARS-CoV-2 enters host cells through CD147-mediated endocytosis, highlighting the potential of blocking this pathway as a preventive approach against SARS-CoV-2 infection.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Oncology
Ze-Kun Liu, Ke-Fei Wu, Ren-Yu Zhang, Ling-Min Kong, Run-Ze Shang, Jian-Jun Lv, Can Li, Meng Lu, Yu-Le Yong, Cong Zhang, Nai-Shan Zheng, Yan-Hong Li, Zhi-Nan Chen, Huijie Bian, Ding Wei
Summary: In this study, a prognostic signature based on pyroptosis-related lncRNAs in hepatocellular carcinoma (HCC) was constructed, showing significant predictive value for HCC patient prognosis and potential clinical guidance for individualized immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hong-Yong Cui, Wei Wei, Mei-Rui Qian, Ruo-Fei Tian, Xin Fu, Hong-Wei Li, Gang Nan, Ting Yang, Peng Lin, Xi Chen, Yu-Meng Zhu, Bin Wang, Xiu-Xuan Sun, Jian-Hua Dou, Jian-Li Jiang, Ling Li, Shi-Jie Wang, Zhi-Nan Chen
Summary: This study identified PDAP1 as a key player in colorectal cancer (CRC) development. PDAP1 overexpression was associated with cell proliferation, migration, invasion, and metastasis in CRC. Inhibiting PDAP1 may be an effective strategy for treating CRC patients with PDAP1 overexpression.
CANCER COMMUNICATIONS
(2022)
Article
Immunology
Yatong Chen, Jing Xu, Xiaodong Wu, Hui Yao, Zhou Yan, Ting Guo, Wenjing Wang, Peixiao Wang, Yu Li, Xiangmin Yang, Hao Li, Huijie Bian, Zhi-Nan Chen
Summary: Deletion of CD147 in T cells limits tumor growth in mouse melanoma and lung cancer. CD147 is upregulated in CD8(+) TILs and coexpressed with immune-checkpoint molecules, leading to increased antitumor responses and potential as a target for cancer immunotherapy.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)