Article
Immunology
Xia Li, Meng Feng, Yanqing Zhao, Yuhan Zhang, Ruixue Zhou, Hang Zhou, Zhen Pang, Hiroshi Tachibana, Xunjia Cheng
Summary: Macrophages play a crucial role in combating amoebiasis by releasing pro-inflammatory cytokines in response to infection. Entamoeba histolytica can activate the NLRP3 inflammasome through secretion of peroxiredoxins during interaction with host cells, potentially offering a novel therapeutic approach for this global threat.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Qinyu Yao, Jia Liu, Qi Cui, Tingting Jiang, Xinya Xie, Xiong Du, Ziwei Zhao, Baochang Lai, Lei Xiao, Nanping Wang
Summary: CCN1/integrin alpha(5)beta(1) is identified as a novel mediator in hepatic lipotoxicity via NLRP3-dependent pyroptosis, providing new evidence for the understanding of non-alcoholic steatohepatitis mechanism.
Review
Immunology
Shanshan Wang, France Moreau, Kris Chadee
Summary: Gasdermins (GSDMs) are a group of proteins that can induce cell death or pyroptosis by forming pores in the plasma membrane. This review provides a comprehensive overview of the expression, activation, biological functions, and regulation of GSDMs, with a focus on their role in host defense against Eh and other protozoan parasitic infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Do-Wan Shim, Hyo-Joung Cho, Inhwa Hwang, Taek-Yeol Jung, Hyun-Seok Kim, Ju Hee Ryu, Je-Wook Yu
Summary: The depletion of NAD(+) affects the innate immune potential of macrophages and has an impact on NLRP3 activation. FK866 facilitates NLRP3 activation by promoting perinuclear clustering of mitochondria, while supplementation with NAD(+) can counteract the FK866-induced caspase-1 cleavage.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Chia George Hsu, Wenjia Li, Mark Sowden, Camila Lage Chavez, Bradford C. Berk
Summary: Pnpt1 plays critical roles in mitochondrial homeostasis and is involved in inflammation by regulating IL-1β and IL-18 secretion. The study demonstrates that Pnpt1 controls NLRP3 inflammasome activation through glycolysis and mt-ROS in macrophages.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Asta Luciunaite, Indre Dalgediene, Rapolas Zilionis, Kristina Masalaite, Milda Norkiene, Andrius Sinkunas, Alma Gedvilaite, Indre Kucinskaite-Kodze, Aurelija Zvirbliene
Summary: This study investigates the effect of viral oligomeric proteins on the inflammatory response in macrophages. It finds that filamentous proteins do not induce inflammation, while spherical proteins mediate an inflammatory response and activate the NLRP3 inflammasome.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Attinder Chadha, Kris Chadee
Summary: Protozoan parasites evade host defenses by hijacking host cellular signaling pathways and transcription factors, with the NF-kappa B pathway being a key target. These parasites manipulate the NF-kappa B pathway to thwart immune responses and ensure survival in the host.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Weifeng Li, Haowen Xu, Jingjing Shao, Jiahao Chen, Yimin Lin, Zhiwei Zheng, Yi Wang, Wu Luo, Guang Liang
Summary: A compound called alantolactone derived from a traditional Chinese medicinal plant has been found to inhibit the activity of NLRP3 inflammasomes, showing potential for the treatment of NLRP3-driven diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chia-Cheng Su, Shu-Chi Wang, I-Chen Chen, Fang-Yen Chiu, Po-Len Liu, Chi-Han Huang, Kuan-Hua Huang, Shih-Hua Fang, Wei-Chung Cheng, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Po-Yen Lee, Ming-Yii Huang, Chia-Yang Li
Summary: The study demonstrated that zerumbone effectively attenuates LPS-induced inflammatory response in macrophages both in vitro and ex vivo by suppressing the activation of the ERK-MAPK and NF-kappa B signaling pathways as well as blocking the activation of the NLRP3 inflammasome, suggesting its potential benefits for treating sepsis and inflammasome-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Xusheng Li, Haiwei Li, Dongbao Cai, Ping Li, Jietian Jin, Xinwei Jiang, Zhenhua Li, Lingmin Tian, Guobing Chen, Jianxia Sun, Weibin Bai
Summary: Pubertal mice exposed to low-dose cadmium exhibit liver inflammation and severe injury, including inflammatory hepatocyte infiltration, increased apoptotic cells, and upregulation of cytokine expression.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Immunology
Ming Ma, Guoyang Li, Minghui Qi, Wei Jiang, Rongbin Zhou
Summary: Inhaled allergens promote activation of NLRP3 inflammasome, leading to allergic asthma. The study found that NLRP3 in alveolar macrophages plays a role in promoting the development of allergic asthma through an inflammasome-dependent mechanism. Targeting the NLRP3 inflammasome with small molecules may offer new treatment options for this disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Takuya Yashiro, Machiko Yamamoto, Sanae Araumi, Mutsuko Hara, Kyoko Yogo, Koichiro Uchida, Kazumi Kasakura, Chiharu Nishiyama
Summary: The study revealed that PU.1 and IRF8 are involved in the monocytic lineage-specific expression of NLRP3 by binding to regulatory elements within its promoter. Knockdown of PU.1 and IRF8 suppresses the activity of the NLRP3 inflammasome.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Bo-Zong Shao, Hai-Yan Xu, Yi-Cheng Zhao, Xiao-Rui Zheng, Fang Wang, Guan-Ren Zhao
Summary: This review provides insights into the pathogenesis and progression of atherosclerosis (AS), as well as the biological features of the nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome. It discusses the role of the NLRP3 inflammasome in AS and its possible mechanisms, and describes various agents with anti-atherosclerotic effects that target the NLRP3 inflammasome.
Article
Immunology
Huiqin Zhou, Wei Zhang, Danxue Qin, Peiqiang Liu, Wenjun Fan, Hao Lv, Lu Tan, Ziang Gao, Yu Xu
Summary: NLRP3 inflammasome activation plays an important role in allergic rhinitis by inducing macrophage pyroptosis and releasing inflammatory mediators to local tissues.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xin-Xin Guan, Hui-Hui Yang, Wen-Jing Zhong, Jia-Xi Duan, Chen-Yu Zhang, Hui-Ling Jiang, Yang Xiang, Yong Zhou, Cha-Xiang Guan
Summary: This study found that the activation of Fn14 worsens acute lung injury (ALI) by amplifying the activation of the NLRP3 inflammasome. Blocking Fn14 may be a potential way to treat ALI.
MOLECULAR MEDICINE
(2022)
Article
Microbiology
Steve Cornick, France Moreau, Kris Chadee
Article
Immunology
L. Mortimer, F. Moreau, S. Cornick, K. Chadee
MUCOSAL IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Tyson Ruetz, Steve Cornick, Julian Andrew Guttman
Article
Multidisciplinary Sciences
Michael Goplen, Manigandan Lejeune, Steve Cornick, France Moreau, Kris Chadee
Review
Medicine, Research & Experimental
Steve Cornick, Kris Chadee
Review
Medicine, Research & Experimental
Steve Cornick, Adelaide Tawiah, Kris Chadee