Article
Immunology
Liam J. O'Neil, Christopher B. Oliveira, Donavon Sandoval-Heglund, Ana Barrera-Vargas, Javier Merayo-Chalico, Eduardo Aguirre-Aguilar, Mariana J. Kaplan, Carmelo Carmona-Rivera
Summary: Anti-CarP antibodies are linked to poor prognosis and bone erosion in rheumatoid arthritis (RA). Neutrophils in RA release modified autoantigens via NETs, including carbamylated LL37. Elevated levels of carbamylated LL37 were found in RA patients' plasma and synovial fluid, and could lead to autoantibody responses and bone damage in RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Haruki Matsumoto, Yuya Fujita, Michio Onizawa, Kenji Saito, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Naoki Matsuoka, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Takeshi Machida, Hiroshi Watanabe, Kiyoshi Migita
Summary: The expression of CEACAM1 is elevated in peripheral blood neutrophils of patients with RA and is associated with rheumatoid inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jiayao Lyu, Lujun Wang, Xiaosheng Bai, Xingjie Du, Jun Wei, Jianxin Wang, Yan Lin, Zhenyu Chen, Zhongbing Liu, Jianming Wu, Zhirong Zhong
Summary: This study successfully loaded methotrexate (MTX) into nanoparticles of human serum albumin modified with mannose for targeted drug delivery to neutrophils, reducing toxicity and showing significant anti-inflammatory, antiangiogenic, and anti-arthritic effects in experimental models. The nanoparticles prolonged the in vivo circulation of MTX and accumulated mainly in arthritic joints, indicating their potential as a useful drug delivery system for rheumatoid arthritis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Immunology
Helen L. Wright, Max Lyon, Elinor A. Chapman, Robert J. Moots, Steven W. Edwards
Summary: This study analyzed the gene expression differences between blood and synovial fluid neutrophils of rheumatoid arthritis patients, highlighting the overexpression of chemokines, ROS production, and NETs production by synovial fluid neutrophils. The research expands the understanding of molecular changes in neutrophil transcriptome during migration in inflamed joints and altered phenotype in rheumatoid arthritis synovial fluid neutrophils.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Sicilia Rezende Oliveira, Jose Alcides Almeida de Arruda, Ayda Henriques Schneider, Valessa Florindo Carvalho, Caio Cavalcante Machado, Joice Dias Correa, Marcela Faria Moura, Leticia Fernanda Duffles, Flavio Falcao Lima de Souza, Gilda Aparecida Ferreira, Fernando Oliveira Costa, Lucas Guimaraes Abreu, Mario Taba Junior, Sandra Yasuyo Fukada, Rene Donizeti Ribeiro de Oliveira, Paulo Louzada-Junior, Fernando de Queiroz Cunha, Tarcilia Aparecida Silva
Summary: This study reveals a potential link between periodontitis and RA through the involvement of NETs, and periodontal therapy can dramatically affect circulating NET levels.
Article
Immunology
Devy Zisman, Mirna Safieh, Elina Simanovich, Joy Feld, Amalia Kinarty, Liron Zisman, Tal Gazitt, Amir Haddad, Muna Elias, Itzhak Rosner, Lisa Kaly, Michal A. Rahat
Summary: The study found that treatment with TCZ in RA patients can decrease circulating levels of EMMPRIN/CD147, increase expression of circulating miR-146a-5p and miR-150-5p, and reduce angiogenic potential. In vitro experiments showed that miR-146a-5p regulates EMMPRIN, and TCZ affects angiogenesis through its effects on EMMPRIN and miR-146a-5p.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jyotsana Kaushal, Akhil Kamboj, Kumari Anupam, Ankit Tandon, Aman Sharma, Archana Bhatnagar
Summary: This study evaluates the role of polymorphonuclear neutrophils (PMNs) in patients with rheumatoid arthritis (RA) and healthy controls. The results demonstrate that PMNs play an important role in mediating immune responses and are associated with gene regulation involved in oxidative and degradative pathways. Additionally, the study found significantly elevated levels of pro-inflammatory cytokines in the serum of RA patients, which correlated with disease severity.
CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Michele Fresneda Alarcon, Zoe McLaren, Helen Louise Wright
Summary: Dysregulated neutrophil activation plays a significant role in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, contributing to inflammation and autoantibody production in both autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Javier Marin-Prida, Arielis Rodriguez-Ulloa, Vladimir Besada, Alexey Llopiz-Arzuaga, Nathalia Vieira Batista, Ignacio Hernandez-Gonzalez, Nancy Pavon-Fuentes, erica Leandro Marciano Vieira, Viviana Falcon-Cama, Emilio F. Acosta, Gillian Martinez-Donato, Majel Cervantes-Llanos, Dai Lingfeng, Luis J. Gonzalez, Julio Raul Fernandez-Masso, Gerardo Guillen-Nieto, Eduardo Penton-Arias, Flavio Almeida Amaral, Mauro Martins Teixeira, Giselle Penton-Rol
Summary: The study found that both C-PC and PCB significantly improved hypernociception, synovial neutrophil infiltration, myeloperoxidase activity, and periarticular cytokine concentrations in the antigen-induced arthritis (AIA) mice model.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Bhargavi Duvvuri, Al Anoud Baddour, Kevin D. Deane, Marie L. Feser, J. Lee Nelson, M. Kristen Demoruelle, Christian Lood
Summary: Elevated levels of total fMet in the circulation of RA patients are associated with disease activity, joint involvement, and the development of rheumatoid nodules. Total fMet levels can predict erosive disease and improve the prognostic ability of ACPA, suggesting a potential role as novel biomarkers for disease monitoring and prognosis in RA. Additionally, circulating mtNFPs induce neutrophil activation through FPR1-dependent mechanisms, indicating FPR1 as a potential therapeutic target for RA.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Pharmacology & Pharmacy
Xiaoxue Lai, Shuo Wang, Miao Hu, Yiming Sun, Meng Chen, Mengyang Liu, Gang Li, Yihui Deng
Summary: The study developed a new treatment strategy using sialic acid-modified doxorubicin hydrochloride liposome, which effectively inhibited tumor growth while alleviating systemic RA symptoms, providing a new approach for the treatment of comorbid tumors and RA.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Rheumatology
Ting-shuang Xu, Shu-yuan Jia, Ping Li
Summary: The study found that serum levels of IL-29 were significantly elevated in RA patients, while IL-28A levels showed no significant change. Both IL-29 and IL-28A exhibited significant chemotactic effects on neutrophils from RA patients. Additionally, the expression of IL-28R1 on neutrophils was significantly elevated in RA patients.
CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
Xuanqi Liu, Yinping Huo, Jingyang Zhao, Guan Wang, Huiyang Liu, Fangrui Yin, Chunyan Pang, Yongfu Wang, Li Bai
Summary: The endothelial cell protein C receptor (EPCR) plays a crucial role in rheumatoid arthritis (RA) by affecting the disease progression and function of polymorphonuclear neutrophils (PMN). PMN cells with low EPCR expression migrate into the joint cavity and contribute to RA synovial inflammation, leading to bone destruction. The formation of PMN-neutrophil extracellular traps (NETs) in RA patients is increased, which can be regulated by the APC-EPCR signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Pei-Dan Yang, Kai-Jun Zhu, Si-Min Lin, Zhi-Xin Chen, Min-Ying Liu, Qing-Ping Liu, Chang-Song Lin, Cong-Qiu Chu, Qiang Xu
Summary: The study revealed that an increased neutrophil count may be associated with renal impairment in rheumatoid arthritis patients, particularly when the neutrophil count exceeds 7.5 x 10(9)/L.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Susama Chokesuwattanaskul, Michele Fresneda Alarcon, Sangeetha Mangalakumaran, Rudi Grosman, Andrew L. Cross, Elinor A. Chapman, David Mason, Robert J. Moots, Marie M. Phelan, Helen L. Wright
Summary: This study investigates the role of altered energy metabolism in neutrophils in rheumatoid arthritis and the effects of different JAK inhibitors on neutrophil metabolism. JAK inhibitors effectively inhibit ROS production and decrease NET production in neutrophils without impairing bacterial killing.