Autophagy in endothelial cells and tumor angiogenesis

Endothelial autophagic flux hampers atherosclerotic lesion development

(2018) Marouane Kheloufi et al.   Autophagy

Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries

(2018) Masahide Oku et al.   BIOESSAYS

Different Adaptive Responses to Hypoxia in Normal and Multiple Myeloma Endothelial Cells

(2018) Irene Filippi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Novel organometallic chloroquine derivative inhibits tumor growth

(2018) Elizabeth A. Hall et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The autophagic network and cancer

(2018) Marissa D. Rybstein et al.   NATURE CELL BIOLOGY

M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma

(2018) Magdalena Jarosz-Biej et al.   PLoS One

Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

(2018) Priyamvada Jayaprakash et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis

(2017) Annabel Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LC3-Associated Phagocytosis and Inflammation

(2017) Bradlee L. Heckmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

(2017) Lin Tian et al.   NATURE

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

(2017) Anne-Clemence Vion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT1-mediated ERβ suppression in the endothelium contributes to vascular aging

(2016) Danli Kong et al.   AGING CELL

Autophagy, lipophagy and lysosomal lipid storage disorders

(2016) Carl Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

Proper autophagy is indispensable for angiogenesis during chick embryo development

(2016) Wen-hui Lu et al.   CELL CYCLE

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

LC3/GABARAP family proteins: autophagy-(un)related functions

(2016) Marco B. E. Schaaf et al.   FASEB JOURNAL

Endorepellin-evoked Autophagy Contributes to Angiostasis

(2016) Atul Goyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment

(2016) Hanna Starobinets et al.   JOURNAL OF CLINICAL INVESTIGATION

In-Depth Proteomics Identifies a Role for Autophagy in Controlling Reactive Oxygen Species Mediated Endothelial Permeability

(2016) Francesca Patella et al.   JOURNAL OF PROTEOME RESEARCH

Exocytosis of Varicella-Zoster Virus Virions Involves a Convergence of Endosomal and Autophagy Pathways

(2016) Erin M. Buckingham et al.   JOURNAL OF VIROLOGY

Antiangiogenic therapy in oncology: current status and future directions

(2016) Gordon C Jayson et al.   LANCET

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

Mechanistic insights into selective autophagy pathways: lessons from yeast

(2016) Jean-Claude Farré et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Involvement of HMGB1 in Resistance to Tumor Vessel-Targeted, Monoclonal Antibody-Based Immunotherapy

(2016) Vito Pistoia et al.   Journal of Immunology Research

Autophagy-Dependent Secretion: Contribution to Tumor Progression

(2016) Tom G. Keulers et al.   Frontiers in Oncology

Intact endothelial autophagy is required to maintain vascular lipid homeostasis

(2015) Kumiko Torisu et al.   AGING CELL

Endothelial cell control of thrombosis

(2015) Jonathan W. Yau et al.   BMC Cardiovascular Disorders

Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations

(2015) Kenzo Koizumi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Vesicular trafficking mechanisms in endothelial cells as modulators of the tumor vasculature and targets of antiangiogenic therapies

(2015) Hannelore Maes et al.   FEBS Journal

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

(2015) C. K. Domigan et al.   JOURNAL OF CELL SCIENCE

Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension

(2015) Qiang Li et al.   JOURNAL OF HYPERTENSION

Proteomics-Based Metabolic Modeling Reveals That Fatty Acid Oxidation (FAO) Controls Endothelial Cell (EC) Permeability

(2015) Francesca Patella et al.   MOLECULAR & CELLULAR PROTEOMICS

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canonical autophagy does not contribute to cellular radioresistance

(2015) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

Tumor angiogenesis, from foe to friend

(2015) L. B. Rivera et al.   SCIENCE

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression

(2015) J Liu et al.   Cell Death & Disease

Intratumoral Myeloid Cells Regulate Responsiveness and Resistance to Antiangiogenic Therapy

(2015) Lee B. Rivera et al.   Cell Reports

PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury

(2015) Weiwei Wu et al.   PLoS One

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1

(2015) Maria Giovanna Francipane et al.   Oncotarget

Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia

(2015) Annalisa Pezzolo et al.   Oncotarget

Autophagy Regulates Vascular Endothelial Cell eNOS and ET-1 Expression Induced by Laminar Shear Stress in an Ex Vivo Perfused System

(2014) Fengxia Guo et al.   ANNALS OF BIOMEDICAL ENGINEERING

Role of Endothelial Cell–Derived Angptl2 in Vascular Inflammation Leading to Endothelial Dysfunction and Atherosclerosis Progression

(2014) Eiji Horio et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of secreted proteins that reflect autophagy dynamics within tumor cells

(2014) Adam A. Kraya et al.   Autophagy

Inhibition of autophagy attenuates pancreatic cancer growth independent ofTP53/TRP53status

(2014) Annan Yang et al.   Autophagy

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors

(2014) Debra Akin et al.   Autophagy

Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability

(2014) Leena P. Bharath et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis

(2014) Tania Valencia et al.   CANCER CELL

NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation

(2014) Sina Koch et al.   DEVELOPMENTAL CELL

Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-Induced Immune Suppression in Renal Cell Carcinoma

(2014) S. Kusmartsev et al.   JOURNAL OF IMMUNOLOGY

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Endocytosis and Autophagy: Exploitation or Cooperation?

(2014) S. A. Tooze et al.   Cold Spring Harbor Perspectives in Biology

MiR-216a: a link between endothelial dysfunction and autophagy

(2014) R Menghini et al.   Cell Death & Disease

Endothelium and Its Alterations in Cardiovascular Diseases: Life Style Intervention

(2014) Gaia Favero et al.   Biomed Research International

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

The N-end rule proteolytic system in autophagy

(2013) Sung Tae Kim et al.   Autophagy

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

(2013) Yidan Wang et al.   Autophagy

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

(2013) Hiroyasu Konno et al.   CELL

EGFR signaling and autophagy dependence for growth, survival, and therapy resistance

(2013) Barry Jutten et al.   CELL CYCLE

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Non-autophagic roles of autophagy-related proteins

(2013) Suresh Subramani et al.   EMBO REPORTS

Exploiting the bad eating habits of Ras-driven cancers

(2013) E. White   GENES & DEVELOPMENT

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis

(2013) Joseph W. Franses et al.   INTERNATIONAL JOURNAL OF CANCER

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor

(2013) Takehiro Torisu et al.   NATURE MEDICINE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy: shaping the tumor microenvironment and therapeutic response

(2013) Hannelore Maes et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells

(2012) Muhammad Jadoon Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational evidence that impaired autophagy contributes to arterial ageing

(2012) Thomas J. LaRocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Shear Stress-Induced Transcription Factor KLF2 Affects Dynamics and Angiopoietin-2 Content of Weibel-Palade Bodies

(2012) Ellen L. van Agtmaal et al.   PLoS One

Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

(2012) Q. McAfee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis

(2011) Seon-Jin Lee et al.   Autophagy

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

High mobility group box 1 promotes endothelial cell angiogenic behavior in vitro and improves muscle perfusion in vivo in response to ischemic injury

(2011) Ulka Sachdev et al.   JOURNAL OF VASCULAR SURGERY

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells

(2011) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericytes and vessel maturation during tumor angiogenesis and metastasis

(2010) Ahmad Raza et al.   AMERICAN JOURNAL OF HEMATOLOGY

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Changes in Vascular Permeability and Expression of Different Angiogenic Factors Following Anti-Angiogenic Treatment in Rat Glioma

(2010) Meser M. Ali et al.   PLoS One

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation

(2009) Leocadio Rodríguez-Mañas et al.   AGING CELL

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark