Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations

Role of TRP channels in the cardiovascular system

(2015) Zhichao Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neurovascular Regulation in the Ischemic Brain

(2015) Katherine Jackman et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel Role of Reactive Oxygen Species–ActivatedtrpMelastatin Channel-2 in Mediating Angiogenesis and Postischemic NeovascularizationSignificance

(2015) Manish Mittal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice

(2015) Byung Hee Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbleeds, Mortality, and Stroke in Alzheimer Disease

(2015) Marije R. Benedictus et al.   JAMA Neurology

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Poly(ADP-ribose) Polymerase-1 Inhibition in Brain Endothelium Protects the Blood—Brain Barrier under Physiologic and Neuroinflammatory Conditions

(2014) Slava Rom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Intracranial artery stenosis and progression from mild cognitive impairment to Alzheimer disease

(2014) J. Zhu et al.   NEUROLOGY

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort

(2014) Claire J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction

(2014) L. Park et al.   Nature Communications

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy

(2014) Alan W. J. Morris et al.   Frontiers in Aging Neuroscience

A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

(2014) Brenda R. Chen et al.   Journal of the American Heart Association

Redox Regulation of Transient Receptor Potential Channels

(2013) Daisuke Kozai et al.   ANTIOXIDANTS & REDOX SIGNALING

VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration

(2013) Peter Carmeliet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cooperative Interaction of trp Melastatin Channel Transient Receptor Potential (TRPM2) With Its Splice Variant TRPM2 Short Variant Is Essential for Endothelial Cell Apoptosis

(2013) Claudie M. Hecquet et al.   CIRCULATION RESEARCH

Endothelial nitric oxide: protector of a healthy mind

(2013) Z. S. Katusic et al.   EUROPEAN HEART JOURNAL

Hypertension

(2013) Giuseppe Faraco et al.   HYPERTENSION

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

(2013) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer Disease in 2020

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias

(2012) M. Yarchoan et al.   BRAIN

Neuronal inhibition and excitation, and the dichotomic control of brain hemodynamic and oxygen responses

(2012) Martin Lauritzen et al.   NEUROIMAGE

Protecting against vascular disease in brain

(2011) Frank M. Faraci   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

(2011) Grant R. Drummond et al.   NATURE REVIEWS DRUG DISCOVERY

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid Triggers Extensive Cerebral Angiogenesis Causing Blood Brain Barrier Permeability and Hypervascularity in Alzheimer's Disease

(2011) Kaan E. Biron et al.   PLoS One

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid- 

(2011) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Blood–Brain Barrier Permeability Abnormalities in Vascular Cognitive Impairment

(2011) Saeid Taheri et al.   STROKE

Transient Receptor Potential Melastatin 2 Expression is Increased Following Experimental Traumatic Brain Injury in Rats

(2010) Naomi L. Cook et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

TRPM2: a multifunctional ion channel for calcium signalling

(2010) Adriana Sumoza-Toledo et al.   JOURNAL OF PHYSIOLOGY-LONDON

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

The use of PET in Alzheimer disease

(2010) Agneta Nordberg et al.   Nature Reviews Neurology

TRPM2 Cation Channels, Oxidative Stress and Neurological Diseases: Where Are We Now?

(2010) Mustafa Nazıroğlu   NEUROCHEMICAL RESEARCH

Probing the Biology of Alzheimer's Disease in Mice

(2010) Karen H. Ashe et al.   NEURON

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy

(2009) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Simultaneous Measurement of Arterial Transit Time, Arterial Blood Volume, and Cerebral Blood Flow Using Arterial Spin-Labeling in Patients with Alzheimer Disease

(2009) T. Yoshiura et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Alzheimer’s β-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2

(2009) Nikunj S. Patel et al.   JOURNAL OF NEUROCHEMISTRY

Age, Neuropathology, and Dementia

(2009) George M. Savva et al.   NEW ENGLAND JOURNAL OF MEDICINE

Progression of Mild Cognitive Impairment to Dementia

(2009) Salka S. Staekenborg et al.   STROKE

β-Amyloid, Blood Vessels, and Brain Function

(2009) Eric E. Smith et al.   STROKE

Role of the Peroxynitrite-Poly(ADP-Ribose) Polymerase Pathway in Human Disease

(2008) Pal Pacher et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypertension and Cerebrovascular Dysfunction

(2008) Costantino Iadecola et al.   Cell Metabolism

The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes

(2008) Ben Buelow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

(2008) Robert D. Bell et al.   NATURE CELL BIOLOGY

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE

Neurovascular signalling defects in neurodegeneration

(2008) Serena Zacchigna et al.   NATURE REVIEWS NEUROSCIENCE

Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances

(2008) Dietmar Rudolf Thal et al.   NEUROBIOLOGY OF AGING

Detection of changed regional cerebral blood flow in mild cognitive impairment and early Alzheimer's dementia by perfusion-weighted magnetic resonance imaging

(2008) Christian Luckhaus et al.   NEUROIMAGE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease

(2008) E. P. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered functional properties of a TRPM2 variant in Guamanian ALS and PD

(2008) M. C. Hermosura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of TRPM2 Channel in Mediating H 2 O 2 -Induced Ca 2+ Entry and Endothelial Hyperpermeability

(2007) Claudie M. Hecquet et al.   CIRCULATION RESEARCH