Systemic clearance of p16 INK4a ‐positive senescent cells mitigates age‐associated intervertebral disc degeneration

Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration

(2017) Oscar Alvarez-Garcia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype

(2017) Kevin Ngo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration

(2017) Kevin Ngo et al.   SPINE

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Molecular mechanisms of biological aging in intervertebral discs

(2016) Nam V. Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin

(2015) Marco Demaria et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Multiple chronic conditions and healthcare costs among adults

(2015) Usha Sambamoorthi et al.   Expert Review of Pharmacoeconomics & Outcomes Research

Expression of Matrix Metalloproteinases is Positively Related to the Severity of Disc Degeneration and Growing Age in the East Asian Lumbar Disc Herniation Patients

(2014) Haidong Xu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

(2013) Albert R. Davalos et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

(2013) Luigi A. Nasto et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

(2012) R M Naylor et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs

(2012) Luigi A. Nasto et al.   MECHANISMS OF AGEING AND DEVELOPMENT

ISSLS Prize Winner

(2012) Luigi A. Nasto et al.   SPINE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Human Nucleus Pulposus Cells React to IL-6

(2010) Rebecca K. Studer et al.   SPINE

Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits

(2010) Takashi Miyamoto et al.   ARTHRITIS RESEARCH & THERAPY

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Increased cell senescence is associated with decreased cell proliferation in vivo in the degenerating human annulus

(2008) Helen E. Gruber et al.   Spine Journal