Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies
出版年份 2019 全文链接
标题
Accelerated bio-cognitive aging in Down syndrome: State of the art and possible deceleration strategies
作者
关键词
-
出版物
AGING CELL
Volume -, Issue -, Pages e12903
出版商
Wiley
发表日期
2019-02-15
DOI
10.1111/acel.12903
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Translating molecular advances in Down syndrome and Fragile X syndrome into therapies
- (2018) Victor Faundez et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome
- (2018) Panagiotis Zis et al. FREE RADICAL BIOLOGY AND MEDICINE
- mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia
- (2018) Fabio Di Domenico et al. FREE RADICAL BIOLOGY AND MEDICINE
- Elevated Markers of Inflammation Are Associated With Longitudinal Changes in Brain Function in Older Adults
- (2018) Kristen N Warren et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Human Aging and Longevity Are Characterized by High Levels of Mitokines
- (2018) Maria Conte et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- DNA methylation-based biomarkers and the epigenetic clock theory of ageing
- (2018) Steve Horvath et al. NATURE REVIEWS GENETICS
- Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes
- (2018) Tze Pin Ng et al. JOURNAL OF ALZHEIMERS DISEASE
- Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis
- (2018) Jared M. Campbell et al. JOURNAL OF ALZHEIMERS DISEASE
- DNA Methylation Clocks in Aging: Categories, Causes, and Consequences
- (2018) Adam E. Field et al. MOLECULAR CELL
- Metformin as an Anticancer Agent
- (2018) Ales Vancura et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth
- (2018) Sam Amin et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Predictors of Age of Diagnosis and Survival of Alzheimer’s Disease in Down Syndrome
- (2017) Amanda Sinai et al. JOURNAL OF ALZHEIMERS DISEASE
- Metformin and thyroid disease
- (2017) Xianghui Meng et al. JOURNAL OF ENDOCRINOLOGY
- DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project
- (2017) Fabio Ciccarone et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
- (2017) Ok Hee Jeon et al. NATURE MEDICINE
- Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline
- (2017) James H. Cole et al. NEUROBIOLOGY OF AGING
- Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes
- (2017) Ariela R. Orkaby et al. NEUROLOGY
- Bone mineral density in adults with Down syndrome
- (2017) A. Carfì et al. OSTEOPOROSIS INTERNATIONAL
- Metformin – a Future Therapy for Neurodegenerative Diseases
- (2017) Magdalena Markowicz-Piasecka et al. PHARMACEUTICAL RESEARCH
- Predicting Age Using Neuroimaging: Innovative Brain Ageing Biomarkers
- (2017) James H. Cole et al. TRENDS IN NEUROSCIENCES
- The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome
- (2017) Andrea Contestabile et al. Frontiers in Cellular Neuroscience
- Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia
- (2017) Devin Wahl et al. Clinical Interventions in Aging
- Biological Age Predictors
- (2017) Juulia Jylhävä et al. EBioMedicine
- Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits
- (2017) Megan Stringer et al. Molecular Genetics & Genomic Medicine
- The burden of trisomy 21 disrupts the proteostasis network in Down syndrome
- (2017) Stefanos Aivazidis et al. PLoS One
- Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence
- (2016) Nicole Noren Hooten et al. AGING CELL
- An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation
- (2016) M. Florencia Iulita et al. Alzheimers & Dementia
- Metformin as a Tool to Target Aging
- (2016) Nir Barzilai et al. Cell Metabolism
- Down syndrome in adults: a 27-year follow-up of adaptive skills
- (2016) M. Arvio et al. CLINICAL GENETICS
- Cognitive Effects of Intentional Weight Loss in Elderly Obese Individuals With Mild Cognitive Impairment
- (2016) Nidia Celeste Horie et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Meta-analysis of Telomere Length in Alzheimer’s Disease
- (2016) Diego A. Forero et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial
- (2016) Rafael de la Torre et al. LANCET NEUROLOGY
- Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis
- (2016) Jorge Iván Castillo-Quan et al. Cell Reports
- The Effect of Diabetes Medication on Cognitive Function: Evidence from the PATH Through Life Study
- (2016) Pushpani M. Herath et al. Biomed Research International
- If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
- (2016) Vladimir N. Anisimov et al. Aging-US
- Identification of a DNA methylation signature in blood cells from persons with Down Syndrome
- (2016) Maria Giulia Bacalini et al. Aging-US
- Interventions to Slow Aging in Humans: Are We Ready?
- (2015) Valter D. Longo et al. AGING CELL
- Accelerated epigenetic aging in Down syndrome
- (2015) Steve Horvath et al. AGING CELL
- Amniocytes from aneuploidy embryos have enhanced random aneuploidy and signs of senescence — Can these findings be related to medical problems?
- (2015) Tal Biron-Shental et al. GENE
- Plasma N-Glycome Signature of Down Syndrome
- (2015) Vincenzo Borelli et al. JOURNAL OF PROTEOME RESEARCH
- Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome
- (2015) Gabriele Deidda et al. NATURE MEDICINE
- Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease
- (2015) Donna M. Wilcock et al. NEUROBIOLOGY OF AGING
- Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice
- (2015) Marissa J. Schafer et al. NEUROBIOLOGY OF AGING
- Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial
- (2015) S. Vigili de Kreutzenberg et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21
- (2015) Víctor Rodríguez-Sureda et al. Oxidative Medicine and Cellular Longevity
- mTOR in Brain Physiology and Pathologies
- (2015) Joël Bockaert et al. PHYSIOLOGICAL REVIEWS
- Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect
- (2015) Yoshifumi Saisho Endocrine Metabolic & Immune Disorders-Drug Targets
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
- (2014) C. A. Bannister et al. DIABETES OBESITY & METABOLISM
- Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
- (2014) C. Franceschi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis
- (2014) Chin Cheng et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Age-Related Changes of Adaptive and Neuropsychological Features in Persons with Down Syndrome
- (2014) Alessandro Ghezzo et al. PLoS One
- Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model
- (2013) Edoardo Parrella et al. AGING CELL
- Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
- (2013) Olga Moiseeva et al. AGING CELL
- Metformin induces up-regulation of blood–brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells
- (2013) Fuyuko Takata et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain
- (2013) Fabio Di Domenico et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Prenatal pharmacotherapy rescues brain development in a Down’s syndrome mouse model
- (2013) Sandra Guidi et al. BRAIN
- Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
- (2013) Filipe Cabreiro et al. CELL
- Adaptive Downregulation of Mitochondrial Function in Down Syndrome
- (2013) Pablo Helguera et al. Cell Metabolism
- Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?
- (2013) J. L. Sanders et al. EPIDEMIOLOGIC REVIEWS
- Senescence in amniocytes and placentas from trisomy 21 pregnancies
- (2013) Aliza Amiel et al. Journal of Maternal-Fetal & Neonatal Medicine
- Reducing GABAA 5 Receptor-Mediated Inhibition Rescues Functional and Neuromorphological Deficits in a Mouse Model of Down Syndrome
- (2013) C. Martinez-Cue et al. JOURNAL OF NEUROSCIENCE
- Systemic oxidative stress in children and teenagers with Down syndrome
- (2013) Thais Regina Garlet et al. LIFE SCIENCES
- Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
- (2013) Rafael De la Torre et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Usp16 contributes to somatic stem-cell defects in Down’s syndrome
- (2013) Maddalena Adorno et al. NATURE
- Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism
- (2013) Sebastiano Collino et al. PLoS One
- BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer’s Disease
- (2013) Christian Gaser et al. PLoS One
- DNA methylation age of human tissues and cell types
- (2013) Steve Horvath GENOME BIOLOGY
- N-glycomic biomarkers of biological aging and longevity: A link with inflammaging
- (2012) Fabio Dall’Olio et al. AGEING RESEARCH REVIEWS
- Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation
- (2012) Jing Wang et al. Cell Stem Cell
- Lithium rescues synaptic plasticity and memory in Down syndrome mice
- (2012) Andrea Contestabile et al. JOURNAL OF CLINICAL INVESTIGATION
- Down syndrome: the brain in trisomic mode
- (2012) Mara Dierssen NATURE REVIEWS NEUROSCIENCE
- Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation
- (2011) Ira T. Lott et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway
- (2011) Daniela Valenti et al. BIOCHEMICAL JOURNAL
- Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome
- (2011) Giovanna Cenini et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- ‘The sedentary heart’: Physical inactivity is associated with cardiac atrophy in adults with an intellectual disability
- (2011) Jeroen C. Vis et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice
- (2011) J Braudeau et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Common toxicities of mammalian target of rapamycin inhibitors
- (2011) Scott A. Soefje et al. Targeted Oncology
- Serum N-glycan profile shift during human ageing
- (2010) Valerie Vanhooren et al. EXPERIMENTAL GERONTOLOGY
- Regulation of Mammalian Autophagy in Physiology and Pathophysiology
- (2010) Brinda Ravikumar et al. PHYSIOLOGICAL REVIEWS
- Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
- (2010) E. Kickstein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A systems biology approach to Down syndrome: Identification of Notch/Wnt dysregulation in a model of stem cells aging
- (2009) C.J. Cairney et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Lithium Restores Neurogenesis in the Subventricular Zone of the Ts65Dn Mouse, a Model for Down Syndrome
- (2009) Patrizia Bianchi et al. BRAIN PATHOLOGY
- Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease
- (2008) B. Boland et al. JOURNAL OF NEUROSCIENCE
- Survival in Elderly Persons with Down Syndrome
- (2008) Antonia M. W. Coppus et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing
- (2008) Valerie Vanhooren et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Shorter telomeres may indicate dementia status in older individuals with Down syndrome
- (2008) Edmund C. Jenkins et al. NEUROBIOLOGY OF AGING
- DNA damage and repair in children with Down's syndrome
- (2007) Zbigniew Morawiec et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search