Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues

Reduced insulin clearance and lower insulin-degrading enzyme expression in the liver might contribute to the thrifty phenotype of protein-restricted mice

(2014) Luiz F. Rezende et al.   BRITISH JOURNAL OF NUTRITION

Impaired amyloid β-degrading enzymes in brain of streptozotocin-induced diabetic rats

(2014) Y. Liu et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain

(2014) Caroline Kerridge et al.   JOURNAL OF NEUROCHEMISTRY

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

(2014) Juan Pablo Maianti et al.   NATURE

Regulation of Insulin Degrading Enzyme Activity by Obesity-Associated Factors and Pioglitazone in Liver of Diet-Induced Obese Mice

(2014) Xiuqing Wei et al.   PLoS One

Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer’s disease

(2014) Natalia N. Nalivaeva et al.   Frontiers in Aging Neuroscience

Transcriptional Regulation of Insulin-degrading Enzyme Modulates Mitochondrial Amyloid β (Aβ) Peptide Catabolism and Functionality

(2013) María C. Leal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ginsenoside Rg1 Decreases Aβ1–42 Level by Upregulating PPARγ and IDE Expression in the Hippocampus of a Rat Model of Alzheimer's Disease

(2013) QianKun Quan et al.   PLoS One

Insulin-degrading Enzyme (IDE)

(2012) Grazia Raffaella Tundo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Can Alzheimer Disease Be a Form of Type 3 Diabetes?

(2012) Giulia Accardi et al.   REJUVENATION RESEARCH

Nuclear signalling by membrane protein intracellular domains: The AICD enigma

(2011) Caroline Beckett et al.   CELLULAR SIGNALLING

Effect of Sodium Valproate Administration on Brain Neprilysin Expression and Memory in Rats

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance

(2011) Samer O. Abdul-Hay et al.   PLoS One

Ameliorative effects of a non-competitive BACE1 inhibitor TAK-070 on Aβ peptide levels and impaired learning behavior in aged rats

(2010) Hideki Takahashi et al.   BRAIN RESEARCH

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid   Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

(2010) Y. Kong et al.   JOURNAL OF NEUROSCIENCE

The benefits and limitations of animal models for translational research in neurodegenerative diseases

(2010) Mathias Jucker   NATURE MEDICINE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme

(2010) Matías B. de Tullio et al.   Prion

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Insulin-Degrading Enzyme: Structure-Function Relationship and its Possible Roles in Health and Disease

(2009) A. Fernandez-Gamba et al.   CURRENT PHARMACEUTICAL DESIGN

Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

(2008) E. Malito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

(2008) Nikolai D Belyaev et al.   EMBO REPORTS

Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity

(2008) Chiara Ciaccio et al.   JOURNAL OF MOLECULAR BIOLOGY

Increased amyloid β-peptide (1–40) level in brain of streptozotocin-induced diabetic rats

(2008) Y. Liu et al.   NEUROSCIENCE