Article
Neurosciences
Tsuyoshi Hamaguchi, Jee Hee Kim, Akane Hasegawa, Ritsuko Goto, Kenji Sakai, Kenjiro Ono, Yoshinori Itoh, Masahito Yamada
Summary: The study found that exogenous A beta seeds from different A beta pathologies induced A beta deposition in the blood vessels rather than the brain parenchyma, which might be the predominant feature of A beta pathology in iatrogenic transmission cases; Contamination of brain tissues from patients with little A beta pathology could lead to iatrogenic transmission of A beta pathology, emphasizing the urgent need for the development of inactivation methods to prevent such transmission.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando J. Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M. Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W. Pouton, Anthony W. Purcell, Owen J. L. Rackham, Enrico Petretto, Jose M. Polo
Summary: The study reveals that microglia associated with A beta plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer's disease (AD) models. This suggests that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mouse model of AD.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Joanna Zukowska, Stephen J. Moss, Vasanta Subramanian, K. Ravi Acharya
Summary: The accumulation of A beta peptide is linked to the development of Alzheimer's disease, and ADEs play a crucial role in its clearance. Upregulation of ADEs provides a potential therapeutic target, with NEP, ECE-1, IDE, and ACE being identified as important enzymes.
Article
Chemistry, Multidisciplinary
Zhongju Ye, Zhao-Jun Yan, Chenhong Zhang, Jun-Li Hou, Shijing Yue, Lehui Xiao
Summary: Anti-A beta therapy has been the main focus in clinical trials for AD prevention and treatment. This study introduced a new strategy using a charged tubular supramolecule to suppress A beta fibrillation, showing efficient inhibition of A beta(40) fibrillation by CTS-A at a very low inhibitor:peptide molar ratio (1:10) and a reduced cytotoxic effect of A beta peptides post-inhibition or disaggregation. The organized supramolecular structure enhances amyloid fibrillar modulation, offering a new approach for AD treatment using supramolecules.
Review
Biochemistry & Molecular Biology
Chu-Qiao Liang, Yan-Mei Li
Summary: The review highlights recent progress in peptide-based inhibitors, including amyloid sequence-derived inhibitors, designed peptides, and peptide mimics, towards pathological amyloid proteins and deposition. These peptides exhibit advanced inhibitory activities against fibrous aggregation as well as enhanced druggability, based on increased understanding of peptide design and precise amyloid structures.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna M. Grochowska, Guilherme M. Gomes, Rajeev Raman, Rahul Kaushik, Liudmila Sosulina, Hiroshi Kaneko, Anja M. Oelschlegel, PingAn Yuanxiang, Irene Reyes-Resina, Gonca Bayraktar, Sebastian Samer, Christina Spilker, Marcel S. Woo, Markus Morawski, Juergen Goldschmidt, Manuel A. Friese, Steffen Rossner, Gemma Navarro, Stefan Remy, Carsten Reissner, Anna Karpova, Michael R. Kreutz
Summary: Soluble beta-amyloid peptide (A beta) causes synaptic dysfunction in early-stage Alzheimer's disease (AD) by suppressing the transcriptional activity of CREB. A beta induces nucleocytoplasmic trafficking of Jacob, which leads to transcriptional inactivation of CREB and loss of synapses. The compound Nitarsone restores CREB activity by hindering the assembly of a Jacob/LMO4/PP1 signalosome, preventing synaptic impairment and cognitive decline in mouse models of AD.
Article
Biochemistry & Molecular Biology
Xuanbao Yao, Jiahao Zhang, Yafei Lu, Yunsong Deng, Ruoxi Zhao, Shifeng Xiao
Summary: This study explored the effects of myricetin, a polyphenol compound abundant in fruits and vegetables, on mitochondrial damages in N2a-SW cells. The results showed that myricetin improved mitochondrial depolarization and increased mitochondrial membrane potential, leading to enhanced mitochondrial biogenesis and genome integrity. Additionally, myricetin restored mitochondrial functions, regulated mitochondrial dynamics and mitophagy, suggesting its potential for promoting neuroprotection in APP/Aβ-related diseases, including Alzheimer's disease.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Pranav Joshi, Florian Riffel, Kanayo Satoh, Masahiro Enomoto, Seema Qamar, Hannah Scheiblich, Nadia Villacampa, Sathish Kumar, Sandra Theil, Samira Parhizkar, Christian Haass, Michael T. Heneka, Paul E. Fraser, Jochen Walter
Summary: Rare coding variants of the microglial triggering receptor expressed on myeloid cells 2 (TREM2) have been found to increase the risk of Alzheimer's disease (AD) by interacting preferentially with oligomeric forms of amyloid beta peptides (Aβ), especially when phosphorylated. This interaction affects the clearance of toxic Aβ species in preclinical models of AD, highlighting the importance of TREM2 in sensing post-translational modifications of Aβ.
Review
Chemistry, Multidisciplinary
Zhi Du, Meng Li, Jinsong Ren, Xiaogang Qu
Summary: This article discusses the progress in the research field of Alzheimer's disease (AD), focusing on various methods and mechanisms for regulating amyloid-beta (A beta) aggregation, as well as the development of multifunctional therapeutic drugs and nanoparticles for comprehensive treatment of AD.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Greta Elovsson, Liza Bergkvist, Ann-Christin Brorsson
Summary: Alzheimer's disease is a neurological disorder associated with proteotoxic events caused by the misfolding and aggregation of the amyloid-beta peptide. Drosophila melanogaster is utilized as a model organism to study the proteotoxicity of the amyloid-beta peptide and screen for drug candidates, which may provide insights into disease progression and potential treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Sachin Ranjan, Shalini Trivedi, Shruti Sharma, Salman Khan, Rakesh Pandey
Summary: The study identified Bakuchiol as an active molecule derived from Psoralea corylifolia that can significantly enhance acetylcholine (ACh) transmission, reduce reactive oxygen species (ROS) levels, and extend lifespan. Further investigation showed that modulation of gene expression related to choline transport, choline acetyltransferase, and acetylcholine transport may be responsible for the increased neural transmission. Bakuchiol also showed efficacy in reducing amyloid beta and lipid levels, possibly through the upregulation of heat shock transcription factor 1 (hsf-1) and autophagy (lgg-1) genes.
NATURAL PRODUCT RESEARCH
(2023)
Review
Engineering, Chemical
Yanxian Zhang, Yijing Tang, Dong Zhang, Yonglan Liu, Jian He, Yung Chang, Jie Zheng
Summary: The research focuses on the mechanism of amyloid cross-seeding between Aβ and hIAPP and its connection between AD and T2D, explores the role of structural compatibility and sequence similarity of amyloid proteins in cross-seeding, and proposes current challenges and future research directions in this less-studied field.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Bikash R. Sahoo, Pritam Kumar Panda, Wenguang Liang, Wei-Jen Tang, Rajeev Ahuja, Ayyalusamy Ramamoorthy
Summary: The study demonstrates that cf-E111Q-IDE degrades Aβ(1-40) through a non-chaperone mechanism with reduced impact on aggregation kinetics. Zinc binding to Aβ(1-40) inactivates cf-E111Q-IDE's catalytic function, while zinc removal restores its function. These findings highlight the catalytic role of cf-E111Q-IDE in Aβ degradation and suggest the development of zinc chelators as a therapeutic strategy to modulate IDE's function.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan Wang, Meiling Lian, Xiaoyu Xiu, Zhiwen Zhang, Liping Song, Shengzhou Wu
Summary: This study found that Dicer1 expression mediated amyloid peptide clearance by increasing APOE and blocking B2 RNA-mediated APOE mRNA degradation, leading to improved spatial memory in an animal model of Alzheimer's disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Chemistry, Medicinal
Angelo Santoro, Manuela Grimaldi, Michela Buonocore, Ilaria Stillitano, Antonio Gloria, Matteo Santin, Fabrizio Bobba, Matilde Sublimi Saponetti, Elena Ciaglia, Anna Maria D'Ursi
Summary: Alzheimer's disease is a common neurodegenerative disorder characterized by the accumulation of amyloid plaques. Many molecules targeting A beta peptides and anti-A beta monoclonal antibodies have been screened as potential drug candidates. In this study, short peptide sequences were designed based on the binding sites of A beta(1-42)/antibodies, and two peptides, WAibH and SYSTPGK, were identified as mimics of solanezumab and aducanumab, respectively. These antibody-derived peptides were found to interact with soluble A beta(1-42) and control its aggregation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Gastroenterology & Hepatology
Vicente Soriano, Carmen de Mendoza, Ana Trevino, Jose Manuel Ramos-Rincon, Victor Moreno-Torres, Octavio Corral, Pablo Barreiro
Summary: Hepatitis delta virus (HDV) is a severe form of chronic viral hepatitis that can lead to cirrhosis, liver cancer, and/or transplantation. The recent approval of bulevirtide and the expected availability of lonafarnib have revolutionized HDV therapy. Combination antiviral therapy is envisioned as a potential cure for hepatitis delta. HIV-HDV patients should be prioritized for new and potentially curative treatments.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Jose-Manuel Ramos-Rincon, Hector Pinargote-Celorio, Carmen de Mendoza, Clara Ramos-Belinchon, Pablo Barreiro, Ana Trevino, Octavio Corral, Vicente Soriano
Summary: Hospital admissions of individuals with HBV infection are increasing in Spain, and while hepatic decompensation events have declined, HBV-related liver cancer continues to rise. Oral antiviral therapies do not have any benefit on hepatitis delta.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Chemistry, Medicinal
Vicente Soriano, Victor Moreno-Torres, Ana Trevino, Octavio Corral, Carmen de Mendoza
Summary: It has been ten years since the identification of NTCP as the cell surface receptor for HBV and HDV entry into hepatocytes. Bulevirtide (BLV) has been developed as a potential inhibitor of NTCP-HBV/HDV binding and has shown promising results in preclinical and clinical studies. Combination therapies with BLV and other anti-HBV/HDV agents are expected to lead to a cure for hepatitis delta in the near future.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Immunology
Vicente Soriano, Victor Moreno-Torres, Carmen De Mendoza, Octavio Corral, Pablo Barreiro
Summary: Coinfection with hepatitis viruses A to E is frequent and causes significant morbidity and mortality in persons living with HIV (PLWH). Hepatitis A and E mainly produce acute self-limited episodes in poor income regions and non-vaccinated travelers. Chronic hepatitis B, C, and D are frequent in PLWH in highly endemic regions and globally in persons who inject drugs and men having sex with men. Rating: 8 out of 10.
Review
Infectious Diseases
Javier Arranz-Herrero, Jesus Presa, Sergio Rius-Rocabert, Alberto Utrero-Rico, Jose Angel Arranz-Arija, Antonio Lalueza, Maria M. Escribese, Jordi Ochando, Vicente Soriano, Estanislao Nistal-Villan
Summary: The clinical burden of influenza is increasing worldwide, with bacterial infections being the main cause of complications and poor clinical outcomes. Streptococcus pneumoniae and Staphylococcus aureus are the most common microorganisms causing bacterial infections in patients with influenza. Early diagnosis and use of antibiotics can improve outcomes in this population.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Vicente Soriano, Antonio Aguilera, Rafael Benito, Rocio Gonzalez-Diez, Elisenda Miro, Paloma Liendo, Juan Carlos Rodriguez-Diaz, Teresa Cabezas, Alberto Richart, Jose Manuel Ramos, Luisa Barea, Carmen Alvarez, Ana Trevino, Felix Gomez-Gallego, Octavio Corral, Carmen de Mendoza
Summary: In Spain, the proportion of adults vaccinated against hepatitis B is still low, with approximately 60% of adults at risk for hepatitis B. Therefore, it is recommended to conduct HBV serological testing and administer HBV vaccines or boosters to all adults.
LIVER INTERNATIONAL
(2023)
Letter
Medicine, General & Internal
V Moreno-Torres, V Soriano
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Debra W. Yen, Vicente Soriano, Pablo Barreiro, Kenneth E. Sherman
CLINICS IN LIVER DISEASE
(2023)
Article
Virology
Carmen de Mendoza, Ariadna Rando, Elisenda Miro, Maria Jose Pena, Iciar Rodriguez-Avial, Diego Ortega, Alejandro Gonzalez-Praetorius, Gabriel Reina, Ilduara Pintos, Maria Jose Pozuelo, Vicente Soriano
Summary: The rate of ATLL is very low in Spain and mostly associated with migrants from HTLV-1 endemic regions. ATLL patients have a poor clinical outcome, with most of them dying within one year. In Spain, HTLV-1 testing should be performed on migrants from HTLV-1 endemic countries and natives who have lived in or had sex partners from such regions.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Virology
Jose Manuel Ramos-Rincon, Hector Pinargote-Celorio, Carmen de Mendoza, Clara Ramos-Belinchon, Victor Moreno-Torres, Ana Trevino, Pablo Barreiro, Octavio Corral, Vicente Soriano
Summary: Hospitalizations due to viral hepatitis significantly declined in Spain during the COVID-19 pandemic. Patients admitted with viral hepatitis experienced a greater mortality during the pandemic period. Deaths were more pronounced when co-infected with SARS-CoV-2 despite having advanced liver disease less frequently.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Manuel Corpas, Carmen de Mendoza, Victor Moreno-Torres, Ilduara Pintos, Pedro Seoane, James R. Perkins, Juan A. G. Ranea, Segun Fatumo, Tamas Korcsmaros, Jose Manuel Martin-Villa, Pablo Barreiro, Octavio Corral, Vicente Soriano
Summary: Characterization of host genetic factors contributing to COVID-19 severity reveals a possible role of T cell response dysfunction, as indicated by the identification of variants in the T cell receptor beta locus associated with severe COVID-19.
Article
Medical Ethics
Vicente Soriano, Borja Montero
Summary: The College of Physicians of Madrid organized a debate on conscientious objection in the medical profession. The main arguments discussed centered around the definition of conscientious objection, the importance of medical ethics, and the potential harm of suppressing the ethical dimension of medical care. The debate also touched on the recent Spanish laws on abortion, euthanasia, and sex re-assignment of minors, highlighting the need to respect the freedom of physicians to refuse actions that go against their ethical values.
Article
Immunology
Oskar Ayerdi, Rafael Benito, Diego Ortega, Antonio Aguilera, Natalia Montiel, Ilduara Pintos, Alberto Diaz de Santiago, Begona Baza, Vicente Soriano, Carmen de Mendoza
Summary: The prevalence of HTLV infection among individuals with STIs in Spain is 0.5%, higher than in the general population. These results suggest the need for universal HTLV screening in individuals attending clinics for STIs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Carmen de-Mendoza, Leire Perez, Ariadna Rando, Gabriel Reina, Antonio Aguilera, Rafael Benito, Jose Maria Eiros, Itziar Rodriguez-Avial, Diego Ortega, Maria Jose Pozuelo, Maria Jose Pena, Vicente Soriano
Summary: HAM is the most common clinical manifestation of HTLV-1 infection in Spain, and it mainly affects middle-aged women migrants from Latin America. Despite the use of antiretroviral therapy, two thirds of HAM patients end up in a wheelchair.
JOURNAL OF CLINICAL VIROLOGY
(2023)
