Article
Biochemistry & Molecular Biology
Yanhong Wang, Yuzhu Hong, Jiyu Yan, Breanna Brown, Xiaoyang Lin, Xiaolin Zhang, Ning Shen, Minghua Li, Jianfeng Cai, Marcia Gordon, David Morgan, Qingyu Zhou, Chuanhai Cao
Summary: This study aimed to investigate the therapeutic effect of low-dose delta-9-tetrahydrocannabinol (THC) in Alzheimer's disease (AD). The results showed that low-dose THC can reduce amyloid-beta aggregation and improve spatial learning in aged AD mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Wei Xiong, Xiaoqin Zhao, Qing Xu, Guihua Wei, Liudai Zhang, Yuqing Fan, Lingmiao Wen, Yanjun Liu, Tinglan Zhang, Li Zhang, Yan Tong, Qiaozhi Yin, Tian-e Zhang, Zhiyong Yan
Summary: This study utilized modern pharmacological methods to evaluate the therapeutic effects of Qisheng Wan formula (QWF) on rats with Alzheimer's disease (AD). Results showed that QWF significantly improved cognition processes in AD rats by decreasing A beta 1-42 deposition and modulating intestinal microbiota, thereby suppressing inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shiveena Bhatia, Manjinder Singh, Pratibha Sharma, Somdutt Mujwar, Varinder Singh, Krishna Kumar Mishra, Thakur Gurjeet Singh, Tanveer Singh, Sheikh Fayaz Ahmad
Summary: Alzheimer's disease, the leading cause of dementia, is characterized by the deposition of plaques and tangles in the brain, leading to cell degeneration. Researchers are developing BACE-1 enzyme inhibitors to prevent plaque buildup. In this study, Elenbecestat analogues were analyzed using structure-based drug design and scaffold morphing, and SB306 and SB12 were found to interact well with the catalytic dyad motifs of the enzyme, showing drug-like properties and high thermodynamic stability.
Article
Pharmacology & Pharmacy
Chang-lan Chen, Hai-li Wang, Feng Qian, Mei-hua Liu, Xiao-xuan Guo, Jing Lv, Jia-hui Huang, Nai-zhi Zhang, Zheng Xiang
Summary: The study found that berbamine hydrochloride has the potential to be an anti-Alzheimer's drug. It improves learning and memory abilities, reduces pathological features, and regulates protein expression related to immune cells and calcium homeostasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Pratibha Sharma, Manjinder Singh
Summary: Alzheimer's disease is a chronic and irreversible neurodegenerative disorder that causes progressive dementia and cognitive impairment. It is a major health challenge in elderly individuals and a leading cause of death worldwide. Several hypotheses have been proposed to explain its complex pathophysiology, and acetylcholinesterase is the main target for its management. This review focuses on chalcone-based compounds, both natural and synthetic, as potential anti-Alzheimer's agents, targeting enzymes and pathways like acetylcholinesterase, beta-secretase, tau proteins, MAO, free radicals, and AGEs, and discussing their structure-activity relationships.
Article
Biochemistry & Molecular Biology
Krista Mineia Wartchow, Leticia Rodrigues, Izabela Swierzy, Michael Buchfelder, Diogo Onofre de Souza, Carlos-Alberto Goncalves, Andrea Kleindienst
Summary: The study found that long-term increased S100B levels have sex-dependent and brain region-specific effects on amyloid-beta processing, highlighting the importance of further investigating signaling pathways and behavioral responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
R. Sonoda, E. Kuramoto, S. Minami, S. E. Matsumoto, Y. Ohyagi, T. Saito, T. Saido, K. Noguchi, T. Goto
Summary: The relationship between oral health and the development of Alzheimer's disease in the elderly is not well understood. This study investigated the association between aging or neurodegeneration of the trigeminal nervous system and the accumulation of A beta(42) oligomers in the pathogenesis of AD. The results suggest that deterioration of autophagy due to aging or neurodegeneration leads to the diffusion of A beta(42) oligomers into the extracellular space and possibly the development of AD.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Marie Tautou, Sabiha Eddarkaoui, Florian Descamps, Paul-Emmanuel Larchanche, Jamal El Bakali, Liesel Mary Goveas, Melanie Dumoulin, Chloe Lamarre, David Blum, Luc Buee, Patricia Melnyk, Nicolas Sergeant
Summary: The study identified two molecules, MAGS02-14 and PEL24-199, with ss-secretase modulatory effects in cellulo. PEL24-199 was shown to restore short-term memory and reduce neurofibrillary degeneration, suggesting that lysosomotropic activity may not be essential for the effect on tau pathology.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Lailiang Qu, Limei Ji, Cheng Wang, Heng Luo, Shang Li, Wan Peng, Fucheng Yin, Dehua Lu, Xingchen Liu, Lingyi Kong, Xiaobing Wang
Summary: The selenium-containing compound 13f, based on ebselen and verubecestat, showed potential anti-Alzheimer's disease and antioxidant stress effects by reducing beta-amyloid production and alleviating oxidative stress. Furthermore, 13f also demonstrated anti-inflammatory and cytoprotective effects, making it a promising candidate for AD treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Behavioral Sciences
Nathan S. Pentkowski, Samuel J. Bouquin, Carlos R. Maestas-Olguin, Zachary M. Villasenor, Benjamin J. Clark
Summary: Alzheimer's disease is a progressive neurodegenerative disorder associated with cognitive and functional impairments. Chronic stress has been linked as a risk factor for AD-related pathology, but a study found that two weeks of daily restraint stress did not further enhance anxiety- or fear-like behaviors in TgF344-AD rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Liudmila Sosulina, Manuel Mittag, Hans-Ruediger Geis, Kerstin Hoffmann, Igor Klyubin, Yingjie Qi, Julia Steffen, Detlef Friedrichs, Niklas Henneberg, Falko Fuhrmann, Daniel Justus, Kevin Keppler, A. Claudio Cuello, Michael J. Rowan, Martin Fuhrmann, Stefan Remy
Summary: The study found that increased intrinsic excitability of CA1 neurons in early stages of Alzheimer's disease may precede inhibitory dysfunction in disease progression.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Plant Sciences
Veronica Amoah, Paul Atawuchugi, Yakubu Jibira, Augustine Tandoh, Paul Poku Sampene Ossei, George Sam, George Ainooson
Summary: The hydroethanolic leaf extract of Lantana camara (LCE) has a prophylactic effect on short-term memory deficit and neuroinflammation induced by scopolamine in zebrafish and mice. LCE improved cognitive impairment and reduced inflammatory response.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rahim Ullah, Gowhar Ali, Ajmal Khan, Sajjad Ahmad, Ahmed Al-Harrasi
Summary: The study investigated the effects of 3NCP on AD using 5xFAD mouse models, showing potential therapeutic effects in reducing amyloid plaques and improving learning and memory. In vivo studies demonstrated that 3NCP did not induce anxiety, significantly reduced beta-amyloid plaques, and decreased BACE-1 expression in the brain tissues. This suggests that 3NCP may be a promising candidate for future AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Bruno P. Imbimbo, Stefania Ippati, Mark Watling, Camillo Imbimbo
Summary: According to the beta-amyloid (A beta) hypothesis, brain A beta accumulation is the primary cause of cognitive deficit and dementia in Alzheimer's disease (AD). While many anti-A beta drugs have failed in clinical trials, recent studies have shown encouraging results for antibodies that clear amyloid plaques. These findings suggest that decreased levels of soluble monomeric A beta may be the main driver of AD, rather than the aggregated forms.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Wojciech K. Panek, David M. Murdoch, Margaret E. Gruen, Freya M. Mowat, Robert D. Marek, Natasha J. Olby
Summary: Similar neurological disorders associated with aging, such as Alzheimer's disease and canine cognitive dysfunction syndrome, have been observed in both humans and dogs. The concentrations of A beta 42 and A beta 40 in plasma increase with age in both species, but decrease in individuals with the diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Neurosciences
Masaomi Miyamoto
CNS NEUROSCIENCE & THERAPEUTICS
(2009)
Article
Neurosciences
Hiroaki Fukumoto, Hideki Takahashi, Naoki Tarui, Junji Matsui, Taisuke Tomita, Mitsuhiro Hirode, Masumi Sagayama, Ryouta Maeda, Makiko Kawamoto, Kazuko Hirai, Jun Terauchi, Yasufumi Sakura, Mitsuru Kakihana, Kaneyoshi Kato, Takeshi Iwatsubo, Masaomi Miyamoto
JOURNAL OF NEUROSCIENCE
(2010)
Article
Pharmacology & Pharmacy
Keiji Nishiyama, Hisao Nishikawa, Koki Kato, Masaomi Miyamoto, Tetsuya Tsukamoto, Keisuke Hirai
Article
Neurosciences
Masaomi Miyamoto
NEUROSCIENCE LETTERS
(2006)
Article
Neurosciences
K Kato, K Hirai, K Nishiyama, O Uchikawa, K Fukatsu, S Ohkawa, Y Kawamata, S Hinuma, M Miyamoto
Article
Biology
K Hirai, M Kita, H Ohta, H Nishikawa, Y Fujiwara, S Ohkawa, M Miyamoto
JOURNAL OF BIOLOGICAL RHYTHMS
(2005)
Article
Neurosciences
N Yukuhiro, H Kimura, H Nishikawa, S Ohkawa, S Yoshikubo, M Miyamoto
Article
Clinical Neurology
M Miyamoto, H Nishikawa, Y Doken, K Hirai, O Uchikawa, S Ohkawa
Article
Chemistry, Medicinal
K Fukatsu, O Uchikawa, M Kawada, T Yamano, M Yamashita, K Kato, K Hirai, S Hinuma, M Miyamoto, S Ohkawa
JOURNAL OF MEDICINAL CHEMISTRY
(2002)
Article
Chemistry, Medicinal
O Uchikawa, K Fukatsu, R Tokunoh, M Kawada, K Matsumoto, Y Imai, S Hinuma, K Kato, H Nishikawa, K Hirai, M Miyamoto, S Ohkawa
JOURNAL OF MEDICINAL CHEMISTRY
(2002)
Article
Biochemistry & Molecular Biology
S Yamamoto, S Oka, M Inoue, M Shimuta, T Manabe, M Takahashi, M Miyamoto, M Asano, J Sakagami, K Sudo, Y Iwakura, K Ono, T Kawasaki
JOURNAL OF BIOLOGICAL CHEMISTRY
(2002)
Article
Oncology
T Hara, J Miyazaki, H Araki, M Yamaoka, N Kanzaki, M Kusaka, M Miyamoto
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.