期刊
JOURNAL OF BIOCHEMISTRY
卷 160, 期 2, 页码 69-75出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvw036
关键词
cellular distribution; importin; multifunction; nuclear localization signal; nuclear transport
资金
- JSPS [15K07068, 25116008]
- Grants-in-Aid for Scientific Research [16H04789, 25116008, 16K18434, 15K07068] Funding Source: KAKEN
Importin a performs the indispensable role of ferrying proteins from the cytoplasm into the nucleus with a transport carrier, importin beta 1. Mammalian cells from mouse or human contain either six or seven importin a subtypes, respectively, each with a tightly regulated expression. Therefore, the combination of subtype expression in a cell defines distinct signaling pathways to achieve progressive changes in gene expression essential for cellular events, such as differentiation. Recent studies reveal that, in addition to nucleocytoplasmic transport, importin as also serve non-transport functions. In this review, we first discuss the physiological significance of importin a as a nuclear transport regulator, and then focus on the functional diversities of importin as based on their specific subcellular and cellular localizations, such as the nucleus and plasma membrane. These findings enrich our knowledge of how importin as actively contribute to various cellular events.
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