标题
Dissecting the Physiology and Pathophysiology of Glucagon-Like Peptide-1
作者
关键词
-
出版物
Frontiers in Endocrinology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-10-11
DOI
10.3389/fendo.2018.00584
参考文献
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- A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
- (2014) Brian Finan et al. NATURE MEDICINE
- GLP-1 amidation efficiency along the length of the intestine in mice, rats and pigs and in GLP-1 secreting cell lines
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- GLP-1(32–36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs
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- Chronic Exposure to GLP-1 Increases GLP-1 Synthesis and Release in a Pancreatic Alpha Cell Line (α-TC1): Evidence of a Direct Effect of GLP-1 on Pancreatic Alpha Cells
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- Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress
- (2014) Srividya Vasu et al. PLoS One
- Dietary Non-Esterified Oleic Acid Decreases the Jejunal Levels of Anorectic N-Acylethanolamines
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- Cross-Species Comparison of Genes Related to Nutrient Sensing Mechanisms Expressed along the Intestine
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- Insulin-like peptide 5 is an orexigenic gastrointestinal hormone
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- Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids
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- Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity
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- GLP-1(28–36) improves β-cell mass and glucose disposal in streptozotocin-induced diabetic mice and activates cAMP/PKA/β-catenin signaling in β-cells in vitro
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- GLP-1-derived nonapeptide GLP-1(28–36)amide represses hepatic gluconeogenic gene expression and improves pyruvate tolerance in high-fat diet-fed mice
- (2013) Wilfred Ip et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Conformational restriction in a series of GPR119 agonists: Differences in pharmacology between mouse and human
- (2013) James S. Scott et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model
- (2013) P. Richards et al. DIABETES
- Generation of L Cells in Mouse and Human Small Intestine Organoids
- (2013) N. Petersen et al. DIABETES
- Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency
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- GLP-1 Effects on Islets: Hormonal, Neuronal, or Paracrine?
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- Effects of Intraduodenal Glutamine on Incretin Hormone and Insulin Release, the Glycemic Response to an Intraduodenal Glucose Infusion, and Antropyloroduodenal Motility in Health and Type 2 Diabetes
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- Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells
- (2013) A. M. Habib et al. DIABETOLOGIA
- GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes
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- FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion
- (2013) Hjalti Kristinsson et al. ENDOCRINOLOGY
- Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: Mechanisms of Diabetes Remission and Role of Gut Hormones
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- Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases
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- GLP-1 Receptor Is Expressed in Human Stomach Mucosa
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- The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
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- The islet ghrelin cell
- (2013) Nils Wierup et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1
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- Differential Effects of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Bypass on Appetite, Circulating Acyl-ghrelin, Peptide YY3-36 and Active GLP-1 Levels in Non-diabetic Humans
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- Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans
- (2013) B. Finan et al. Science Translational Medicine
- Different types of toxins targeting TRPV1 in pain
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- A fatty gut feeling
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- Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
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- Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency
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- TRPV1 induction in airway vagal low-threshold mechanosensory neurons by allergen challenge and neurotrophic factors
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- Transient Receptor Potential Vanilloid 1 Activation Enhances Gut Glucagon-Like Peptide-1 Secretion and Improves Glucose Homeostasis
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- Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers
- (2012) T. E. Adrian et al. DIABETOLOGIA
- A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
- (2012) P. Marchetti et al. DIABETOLOGIA
- Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3
- (2012) Brian D. Hudson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The G Protein-coupled Receptor Family C Group 6 Subtype A (GPRC6A) Receptor Is Involved in Amino Acid-induced Glucagon-like Peptide-1 Secretion from GLUTag Cells
- (2012) Manami Oya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Unraveling oxyntomodulin, GLP1's enigmatic brother
- (2012) Alessandro Pocai JOURNAL OF ENDOCRINOLOGY
- GLP1-derived nonapeptide GLP1(28–36)amide protects pancreatic β-cells from glucolipotoxicity
- (2012) Zhengu Liu et al. JOURNAL OF ENDOCRINOLOGY
- The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine
- (2012) Oliver J. Mace et al. JOURNAL OF PHYSIOLOGY-LONDON
- GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function
- (2012) Shinji Odori et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
- (2012) Atsuhiko Ichimura et al. NATURE
- Functional interactions between the gut microbiota and host metabolism
- (2012) Valentina Tremaroli et al. NATURE
- INSL5 is a novel marker for human enteroendocrine cells of the large intestine and neuroendocrine tumours
- (2012) THATCHAWAN THANASUPAWAT et al. ONCOLOGY REPORTS
- Host-Gut Microbiota Metabolic Interactions
- (2012) J. K. Nicholson et al. SCIENCE
- Neurotensin and its receptors in the control of glucose homeostasis
- (2012) Jean Mazella et al. Frontiers in Endocrinology
- Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways
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- Pleiotropic Effects of GIP on Islet Function Involve Osteopontin
- (2011) V. Lyssenko et al. DIABETES
- Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1-Stimulated Postprandial Insulin Secretion in Humans
- (2011) M. Salehi et al. DIABETES
- Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2
- (2011) G. Tolhurst et al. DIABETES
- Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients
- (2011) T. Narita et al. DIABETES OBESITY & METABOLISM
- Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4
- (2011) Scott E. Kanoski et al. ENDOCRINOLOGY
- Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure
- (2011) Mitsuhiro Watanabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis
- (2011) Safina Ali et al. JOURNAL OF CLINICAL INVESTIGATION
- Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
- (2011) Helga Ellingsgaard et al. NATURE MEDICINE
- GLP-1-derived nonapeptide GLP-1(28–36)amide inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice
- (2011) Eva Tomas et al. REGULATORY PEPTIDES
- Stimulating β-Cell Replication and Improving Islet Graft Function by AR231453, A gpr119 Agonist
- (2011) J. Gao et al. TRANSPLANTATION PROCEEDINGS
- Possible involvement of GLP-1(9-36) in the regional haemodynamic effects of GLP-1(7-36) in conscious rats
- (2010) SM Gardiner et al. BRITISH JOURNAL OF PHARMACOLOGY
- A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
- (2010) Christopher J. Bohlen et al. CELL
- GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
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- Peptide YY Is Critical for Acylethanolamine Receptor Gpr119-Induced Activation of Gastrointestinal Mucosal Responses
- (2010) Helen M. Cox et al. Cell Metabolism
- Glucagon-Like Peptide (GLP)-1(9-36)Amide-Mediated Cytoprotection Is Blocked by Exendin(9-39) Yet Does Not Require the Known GLP-1 Receptor
- (2010) Kiwon Ban et al. ENDOCRINOLOGY
- Glucagon-Like Peptide-1 Receptor Knockout Mice Are Protected from High-Fat Diet-Induced Insulin Resistance
- (2010) Julio E. Ayala et al. ENDOCRINOLOGY
- Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Pancreatic Islet α-Cells and Promotes Insulin Secretion
- (2010) Yukihiro Fujita et al. GASTROENTEROLOGY
- The G-Protein−Coupled Receptor GPR40 Directly Mediates Long-Chain Fatty Acid−Induced Secretion of Cholecystokinin
- (2010) Alice P. Liou et al. GASTROENTEROLOGY
- Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide
- (2010) Izumi Kaji et al. JOURNAL OF MOLECULAR HISTOLOGY
- TRP channels and their implications in metabolic diseases
- (2010) Zhiming Zhu et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: Role of peripherally secreted and centrally produced peptides
- (2010) Niels Vrang et al. PROGRESS IN NEUROBIOLOGY
- Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of β-cell regeneration
- (2010) German Kilimnik et al. Islets
- Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls
- (2010) Daisuke Yabe et al. Journal of Diabetes Investigation
- Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice
- (2009) Ryuichi Moriya et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon
- (2009) Kenjiro Matsumoto et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- T1r3 and α-Gustducin in Gut Regulate Secretion of Glucagon-like Peptide-1
- (2009) Zaza Kokrashvili et al. Annals of the New York Academy of Sciences
- GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell
- (2009) L. M. Lauffer et al. DIABETES
- Glucagon-Like Peptide-1 Protects -Cells Against Apoptosis by Increasing the Activity of an Igf-2/Igf-1 Receptor Autocrine Loop
- (2009) M. Cornu et al. DIABETES
- From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus
- (2009) R. A. DeFronzo DIABETES
- Sequence Polymorphisms Provide a Common Consensus Sequence for GPR41 and GPR42
- (2009) Chen W. Liaw et al. DNA AND CELL BIOLOGY
- The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety
- (2009) Astrid J. Smeets et al. EUROPEAN JOURNAL OF NUTRITION
- Distribution and regulation of protein expression of the free fatty acid receptor GPR120
- (2009) Satoshi Miyauchi et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Dietary Capsaicin Reduces Obesity-induced Insulin Resistance and Hepatic Steatosis in Obese Mice Fed a High-fat Diet
- (2009) Ji-Hye Kang et al. Obesity
- Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism
- (2009) Mary-Elizabeth Patti et al. Obesity
- The cardioprotective and inotropic components of the postconditioning effects of GLP-1 and GLP-1(9–36)a in an isolated rat heart
- (2009) Alvilde Ossum et al. PHARMACOLOGICAL RESEARCH
- Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
- (2009) Philippe Lefebvre et al. PHYSIOLOGICAL REVIEWS
- Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis
- (2009) Eva Tomas et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo
- (2008) Yukihiro Fujita et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The Lipid Messenger OEA Links Dietary Fat Intake to Satiety
- (2008) Gary J. Schwartz et al. Cell Metabolism
- Glucose Sensing in L Cells: A Primary Cell Study
- (2008) Frank Reimann et al. Cell Metabolism
- Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways
- (2008) Kiwon Ban et al. CIRCULATION
- Lack of FFAR1/GPR40 Does Not Protect Mice From High-Fat Diet-Induced Metabolic Disease
- (2008) H. Lan et al. DIABETES
- Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion
- (2008) S. Edfalk et al. DIABETES
- Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
- (2008) H. E. Parker et al. DIABETOLOGIA
- Brain Glucagon-Like Peptide 1 Signaling Controls the Onset of High-Fat Diet-Induced Insulin Resistance and Reduces Energy Expenditure
- (2008) Claude Knauf et al. ENDOCRINOLOGY
- TRPV1-null mice are protected from diet-induced obesity
- (2008) Arianne L. Motter et al. FEBS LETTERS
- The Role of Transient Receptor Potential Channels in Metabolic Syndrome
- (2008) Daoyan Liu et al. HYPERTENSION RESEARCH
- Orlistat Inhibition of Intestinal Lipase Acutely Increases Appetite and Attenuates Postprandial Glucagon-Like Peptide-1-(7–36)-Amide-1, Cholecystokinin, and Peptide YY Concentrations
- (2008) Mark Ellrichmann et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8
- (2008) L. De Petrocellis et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- CART peptides: regulators of body weight, reward and other functions
- (2008) G. Rogge et al. NATURE REVIEWS NEUROSCIENCE
- Review: Enteroendocrine cells: Neglected players in gastrointestinal disorders?
- (2008) Gordon W. Moran et al. Therapeutic Advances in Gastroenterology
- EFFECTS OF DIPEPTIDYL PEPTIDASE IV INHIBITION ON ARTERIAL BLOOD PRESSURE
- (2007) Edwin K Jackson et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Protective effects of GLP-1 analogues exendin-4 and GLP-1(9–36) amide against ischemia–reperfusion injury in rat heart
- (2007) David P. Sonne et al. REGULATORY PEPTIDES
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