MECHANISMS IN ENDOCRINOLOGY: Bile acid sequestrants in type 2 diabetes: potential effects on GLP1 secretion

Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids

(2013) Justine H. Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12 -Hydroxylated Bile Acids

(2013) R. A. Haeusler et al.   DIABETES

Diurnal Glucose Profiles Using Continuous Glucose Monitoring to Identify the Glucose-Lowering Characteristics of Colesevelam HCL (Welchol)

(2013) Roger Mazze et al.   Endocrine Practice

Effects of Chenodeoxycholic Acid on the Secretion of Gut Peptides and Fibroblast Growth Factors in Healthy Humans

(2013) A. C. Meyer-Gerspach et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Incretin secretion stimulated by ursodeoxycholic acid in healthy subjects

(2013) Masanori Murakami et al.   SpringerPlus

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

(2012) Matthew J. Potthoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients

(2012) David P. Sonne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

(2012) Divya P. Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Circulating Fibroblast Growth Factors as Metabolic Regulators—A Critical Appraisal

(2012) Bo Angelin et al.   Cell Metabolism

The Effect of a Bile Acid Sequestrant on Glucose Metabolism in Subjects With Type 2 Diabetes

(2012) G. Smushkin et al.   DIABETES

Colesevelam Improves Oral but Not Intravenous Glucose Tolerance by a Mechanism Independent of Insulin Sensitivity and  -Cell Function

(2012) A. L. Marina et al.   DIABETES CARE

Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans

(2012) T. Wu et al.   DIABETES OBESITY & METABOLISM

Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers

(2012) T. E. Adrian et al.   DIABETOLOGIA

A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin

(2012) Kristoffer L. Egerod et al.   ENDOCRINOLOGY

The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

(2012) Dimitri J. Pournaras et al.   ENDOCRINOLOGY

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

(2012) Farzad Alemi et al.   GASTROENTEROLOGY

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass

(2012) M. Simonen et al.   OBESITY SURGERY

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

(2012) Mitsuhiro Watanabe et al.   PLoS One

Clinical Effects of Colesevelam in Hispanic Subjects with Primary Hyperlipidemia and Prediabetes

(2012) Julio Rosenstock et al.   POSTGRADUATE MEDICINE

Combination Treatment with Atorvastatin plus Niacin Provides Effective Control of Complex Dyslipidemias: A Literature Review

(2012) James M. McKenney   POSTGRADUATE MEDICINE

Incretin physiology beyond glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides

(2011) J. F. Rehfeld   Acta Physiologica

The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans

(2011) A. C. Gerspach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs

(2011) Ajay Kumar Jain et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion

(2011) HE Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of the definition of type II diabetes remission in the evaluation of bariatric surgery for metabolic disorders

(2011) D. J. Pournaras et al.   BRITISH JOURNAL OF SURGERY

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia

(2011) Rebecca A. Haeusler et al.   Cell Metabolism

The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)

(2011) R.E. Steinert et al.   CLINICAL NUTRITION

Bile Acid Metabolism and the Pathogenesis of Type 2 Diabetes

(2011) Janne Prawitt et al.   Current Diabetes Reports

Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

(2011) V. Gorboulev et al.   DIABETES

Glucose-Dependent Insulinotropic Polypeptide: A Bifunctional Glucose-Dependent Regulator of Glucagon and Insulin Secretion in Humans

(2011) M. Christensen et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus

(2011) R. S. Kootte et al.   DIABETES OBESITY & METABOLISM

Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study

(2011) C. Beysen et al.   DIABETOLOGIA

Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery

(2011) Peter L.M. Jansen et al.   DIGESTIVE DISEASES

The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract

(2011) Serge J.L.B. Zweers et al.   HEPATOLOGY

Glucose and Insulin Induction of Bile Acid Synthesis

(2011) Tiangang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

(2011) Mitsuhiro Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

(2011) Katrine B. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans

(2011) Johann Ockenga et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

(2011) Tingting Li et al.   MOLECULAR ENDOCRINOLOGY

Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults

(2011) Bertrand Cariou et al.   Nutrition & Metabolism

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Bile-induced secretion of glucagon-like peptide-1: pathophysiological implications in type 2 diabetes?

(2010) Filip K. Knop   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1

(2010) Quan Shang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance

(2010) Tim C. M. A. Schreuder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin

(2010) R. E. Roberts et al.   CLINICAL ENDOCRINOLOGY

Effects of colesevelam on LDL-C, A1c and GLP-1 levels in patients with type 1 diabetes: a pilot randomized double-blind trial

(2010) S. K. Garg et al.   DIABETES OBESITY & METABOLISM

The environment within: how gut microbiota may influence metabolism and body composition

(2010) A. Vrieze et al.   DIABETOLOGIA

Colesevelam Hydrochloride to Treat Hypercholesterolemia and Improve Glycemia in Prediabetes: A Randomized, Prospective Study

(2010) Yehuda Handelsman et al.   Endocrine Practice

The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity

(2010) Iuliana Ristea Popescu et al.   FEBS LETTERS

Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism

(2010) Gemma Brufau et al.   HEPATOLOGY

Bile acid sequestrants improve glycemic control in type 2 diabetes: A proposed mechanism implicating glucagon-like peptide 1 release

(2010) Alan F. Hofmann   HEPATOLOGY

Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATPchannels

(2010) Brigitte Lavoie et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Effect of Colesevelam Hydrochloride on Insulin Sensitivity and Secretion in Patients With Type 2 Diabetes: A Pilot Study

(2010) Sherwyn L. Schwartz et al.   Metabolic Syndrome and Related Disorders

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

(2010) D. P. Poole et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Plasma bile acids are not associated with energy metabolism in humans

(2010) Gemma Brufau et al.   Nutrition & Metabolism

Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting

(2010) Karsten Suhre et al.   PLoS One

Effects of biliary and pancreatic juice diversion into the ileum on gastrointestinal motility and gut hormone secretion in conscious dogs

(2010) Manabu Sato et al.   SURGERY

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Effects of Chenodeoxycholate and a Bile Acid Sequestrant, Colesevelam, on Intestinal Transit and Bowel Function

(2009) Suwebatu T. Odunsi–Shiyanbade et al.   Clinical Gastroenterology and Hepatology

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

(2009) Patrice Cani et al.   CURRENT PHARMACEUTICAL DESIGN

GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell

(2009) L. M. Lauffer et al.   DIABETES

Bile Acids and Metabolic Regulation: Mechanisms and clinical responses to bile acid sequestration

(2009) B. Staels et al.   DIABETES CARE

Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma

(2009) J. Hong et al.   GUT

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

(2009) Verena Keitel et al.   HEPATOLOGY

An Increased Flux through the Glucose 6-Phosphate Pool in Enterocytes Delays Glucose Absorption inFxr–/–Mice

(2009) Theo H. van Dijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Fat Hydrolysis in Regulating Glucagon-Like Peptide-1 Secretion

(2009) Svetlana Beglinger et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Serum bile acid along with plasma incretins and serum high–molecular weight adiponectin levels are increased after bariatric surgery

(2009) Hiroshi Nakatani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

(2009) Mary-Elizabeth Patti et al.   Obesity

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Liraglutide, but not vildagliptin, restores normoglycaemia and insulin content in the animal model of type 2 diabetes, Psammomys obesus

(2009) Louise Vedtofte et al.   REGULATORY PEPTIDES

Incretin and islet hormonal responses to fat and protein ingestion in healthy men

(2008) Richard D. Carr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?

(2008) Xinjie Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Efficacy and Safety of Colesevelam in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control Receiving Insulin-Based Therapy

(2008) Ronald B. Goldberg   ARCHIVES OF INTERNAL MEDICINE

Colesevelam Hydrochloride Therapy in Patients With Type 2 Diabetes Mellitus Treated With Metformin

(2008) Harold E. Bays et al.   ARCHIVES OF INTERNAL MEDICINE

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Farnesoid X Receptor Induces GLUT4 Expression Through FXR Response Element in the GLUT4 Promoter

(2008) Hong Shen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion

(2008) S. Edfalk et al.   DIABETES

Colesevelam HCl Improves Glycemic Control and Reduces LDL Cholesterol in Patients With Inadequately Controlled Type 2 Diabetes on Sulfonylurea-Based Therapy

(2008) V. A. Fonseca et al.   DIABETES CARE

Fifty years of advances in bile acid synthesis and metabolism

(2008) David W. Russell   JOURNAL OF LIPID RESEARCH

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting bile-acid signalling for metabolic diseases

(2008) Charles Thomas et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast growth factor‐19: Development, analytical characterization and clinical evaluation of a new ELISA test

(2008) D. Stejskal et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION